FOG14113
EOG8GB5S0

sce:SDO1

Genes: 33

SGD Description
Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes


PomBase Description
SBDS family ribosome maturation protein Sdo1 (predicted)


AspGD Description
Ortholog(s) have guanyl-nucleotide exchange factor activity, role in mature ribosome assembly and cytosol, nucleolus, polysome, preribosome, large subunit precursor localization


References

Hazbun TR, et al. (2003 Dec). Assigning function to yeast proteins by integration of technologies.

Savchenko A, et al. (2005 May 13). The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.

Shammas C, et al. (2005 May 13). Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome.

Menne TF, et al. (2007 Apr). The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Moore JB 4th, et al. (2010 Jan). Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%