FOG14116
EOG8GB5R9

sce:ASF1

Genes: 31

SGD Description
Nucleosome assembly factor; involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition; relocalizes to the cytosol in response to hypoxia


PomBase Description
histone chaperone Cia1


AspGD Description
Ortholog(s) have histone binding activity


References

Le S, et al. (1997 Sep 15). Two new S-phase-specific genes from Saccharomyces cerevisiae.

Tyler JK, et al. (1999 Dec 2). The RCAF complex mediates chromatin assembly during DNA replication and repair.

Sharp JA, et al. (2001 Apr 3). Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing.

Meijsing SH, et al. (2001 Dec 1). The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.

Osada S, et al. (2001 Dec 1). The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.

Emili A, et al. (2001 Jan). Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1.

Sutton A, et al. (2001 Jun). Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription.

Hu F, et al. (2001 May 1). Asf1 links Rad53 to control of chromatin assembly.

Krawitz DC, et al. (2002 Jan). Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing.

Umehara T, et al. (2002 Jan). Polyanionic stretch-deleted histone chaperone cia1/Asf1p is functional both in vivo and in vitro.

Chimura T, et al. (2002 Jul 9). Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID.

Daganzo SM, et al. (2003 Dec 16). Structure and function of the conserved core of histone deposition protein Asf1.

Schwartz MF, et al. (2003 Jul-Aug). FHA domain-mediated DNA checkpoint regulation of Rad53.

Sutton A, et al. (2003 May 9). Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex.

Robinson KM, et al. (2003 Nov). Replication-independent assembly of nucleosome arrays in a novel yeast chromatin reconstitution system involves antisilencing factor Asf1p and chromodomain protein Chd1p.

Lee SJ, et al. (2003 Sep). Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.

Glowczewski L, et al. (2004 Dec). Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.

Ramey CJ, et al. (2004 Dec). Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1.

Adkins MW, et al. (2004 Dec 10). The histone chaperone Asf1p mediates global chromatin disassembly in vivo.

Adkins MW, et al. (2004 Jun 4). Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.

Prado F, et al. (2004 May). The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange.

Lewis LK, et al. (2005). Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair.

Osada S, et al. (2005). Chromatin assembly factor Asf1p-dependent occupancy of the SAS histone acetyltransferase complex at the silent mating-type locus HMLalpha.

Harkness TA, et al. (2005 Apr). Contribution of CAF-I to anaphase-promoting-complex-mediated mitotic chromatin assembly in Saccharomyces cerevisiae.

Mousson F, et al. (2005 Apr 26). Structural basis for the interaction of Asf1 with histone H3 and its functional implications.

Linger J, et al. (2005 Dec). The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents.

Padmanabhan B, et al. (2005 Dec). Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Zabaronick SR, et al. (2005 Jan). The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase.

Schermer UJ, et al. (2005 Jul 22). Histones are incorporated in trans during reassembly of the yeast PHO5 promoter.

Franco AA, et al. (2005 Jun 1). Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C.

Robinson KM, et al. (2005 Mar 22). Gal4-VP16 directs ATP-independent chromatin reorganization in a yeast chromatin assembly system.

Sharp JA, et al. (2005 Nov). Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.

Green EM, et al. (2005 Nov 22). Replication-independent histone deposition by the HIR complex and Asf1.

Schneider J, et al. (2006 Dec 8). Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.

Celic I, et al. (2006 Jul 11). The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

Tamburini BA, et al. (2006 Jun). Dominant mutants of the Saccharomyces cerevisiae ASF1 histone chaperone bypass the need for CAF-1 in transcriptional silencing by altering histone and Sir protein recruitment.

Korber P, et al. (2006 Mar 3). The histone chaperone Asf1 increases the rate of histone eviction at the yeast PHO5 and PHO8 promoters.

Kats ES, et al. (2006 Mar 7). Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutants.

Recht J, et al. (2006 May 2). Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis.

Schwabish MA, et al. (2006 May 5). Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.

English CM, et al. (2006 Nov 3). Structural basis for the histone chaperone activity of Asf1.

Linger J, et al. (2006 Oct). Global replication-independent histone H4 exchange in budding yeast.

Adkins MW, et al. (2007 Jan 12). The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase.

Tsubota T, et al. (2007 Mar 9). Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes.

Malay AD, et al. (2008 May 16). Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.

Matsuo Y, et al. (2011 Apr 15). Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.

Mizuki F, et al. (2011 Apr 29). The HIRA complex subunit Hip3 plays important roles in the silencing of meiosis-specific genes in Schizosaccharomyces pombe.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Yamane K, et al. (2011 Jan 7). Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Tanae K, et al. (2012). Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Tanae K, et al. (2012 Nov 30). Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.

Tang Z, et al. (2012 Oct 1). Interacting factors and cellular localization of SR protein-specific kinase Dsk1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%