FOG14111
EOG8GB5S6

sce:STS1

Genes: 31

SGD Description
Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation


PomBase Description
tethering factor for nuclear proteasome Cut8


AspGD Description
Ortholog(s) have polyubiquitin binding, sterol binding activity


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Hirano T, et al. (1986 Nov). Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Liang S, et al. (1993 Dec). Multicopy STS1 restores both protein transport and ribosomal RNA stability in a new yeast sec23 mutant allele.

Houman F, et al. (1994 Sep). DBF8, an essential gene required for efficient chromosome segregation in Saccharomyces cerevisiae.

Samejima I, et al. (1994 Sep). Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase.

Amrani N, et al. (1996 Oct 16). Mutations in STS1 suppress the defect in 3' mRNA processing caused by the rna15-2 mutation in Saccharomyces cerevisiae.

Tabb MM, et al. (2000 Aug). Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation.

Tatebe H, et al. (2000 Nov 2). Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Dunand-Sauthier I, et al. (2002 May). Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.

Matsumura T, et al. (2003 Apr). A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.

Yen HC, et al. (2003 Jan 24). Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome.

Ideue T, et al. (2004 Jun 15). The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Takeda K, et al. (2005 Aug 12). Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8.

Romero-Perez L, et al. (2007 Dec 7). Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway.

Kearsey SE, et al. (2007 Mar). Fission yeast Cut8 is required for the repair of DNA double-strand breaks, ribosomal DNA maintenance, and cell survival in the absence of Rqh1 helicase.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Calvo IA, et al. (2009 Aug 12). Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Chen L, et al. (2011 Jan 28). Sts1 plays a key role in targeting proteasomes to the nucleus.

Andersen KM, et al. (2011 May 1). Txl1 and Txc1 are co-factors of the 26S proteasome in fission yeast.

Takeda K, et al. (2011 Oct 11). Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.

Ravin NV, et al. (2013 Nov 27). Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

Kitagawa T, et al. (2014 Apr 7). The 19S proteasome subunit Rpt3 regulates distribution of CENP-A by associating with centromeric chromatin.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%