FOG12701
EOG8KWH83

sce:KAP95

Genes: 33

SGD Description
Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p


PomBase Description
karyopherin Kap95


AspGD Description
Ortholog(s) have cytoplasm, nuclear envelope, nuclear periphery localization


References

Rexach M, et al. (1995 Dec 1). Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins.

Enenkel C, et al. (1995 Jul 14). Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes.

Floer M, et al. (1996 Mar 8). The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein.

Schlenstedt G, et al. (1997 Oct 15). Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Ström AC, et al. (2001). Importin-beta-like nuclear transport receptors.

Mosammaparast N, et al. (2001 Apr 16). Nuclear import of histone H2A and H2B is mediated by a network of karyopherins.

Liu SM, et al. (2005 Jun 10). Structural basis for the high-affinity binding of nucleoporin Nup1p to the Saccharomyces cerevisiae importin-beta homologue, Kap95p.

Lee SJ, et al. (2005 Jun 2). Structural basis for nuclear import complex dissociation by RanGTP.

Osmani AH, et al. (2006 Dec). Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.

Forwood JK, et al. (2008 Nov 21). Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.

Forwood JK, et al. (2010 Sep 8). Quantitative structural analysis of importin-β flexibility: paradigm for solenoid protein structures.

Markina-Iñarrairaegui A, et al. (2011 Oct). Nuclear transporters in a multinucleated organism: functional and localization analyses in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Etxebeste O, et al. (2013). Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%