FOG12699
EOG8KWH87

sce:TYW1

Genes: 26

SGD Description
Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron


PomBase Description
wybutosine biosynthesis protein Tyw1 (predicted)


AspGD Description
Ortholog(s) have role in wybutosine biosynthetic process and endoplasmic reticulum localization


References

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Waas WF, et al. (2005 Nov 11). Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs.

Noma A, et al. (2006 May 17). Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%