FOG05059
EOG8BRV35

sce:BIK1

Genes: 22

SGD Description
Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170


PomBase Description
CLIP170 family protein Tip1


AspGD Description
Ortholog(s) have microtubule plus-end binding, protein homodimerization activity


References

Trueheart J, et al. (1987 Jul). Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

Berlin V, et al. (1990 Dec). BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin.

Brunner D, et al. (2000 Sep 1). CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast.

Behrens R, et al. (2002 May 27). Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.

Hirata D, et al. (2002 Sep 16). Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.

Browning H, et al. (2003 Sep). Targeted movement of cell end factors in fission yeast.

Busch KE, et al. (2004 Apr 6). The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules.

Busch KE, et al. (2004 Jun). Tea2p kinesin is involved in spatial microtubule organization by transporting tip1p on microtubules.

Feierbach B, et al. (2004 Jun 7). Regulation of a formin complex by the microtubule plus end protein tea1p.

Niccoli T, et al. (2004 Nov 1). The p150-Glued Ssm4p regulates microtubular dynamics and nuclear movement in fission yeast.

Martin SG, et al. (2005 Apr). Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity.

Pardo M, et al. (2005 Apr 15). The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Zimmerman S, et al. (2005 Jun). Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.

Masuda H, et al. (2006 Apr). The carboxy-terminus of Alp4 alters microtubule dynamics to induce oscillatory nuclear movement led by the spindle pole body in Schizosaccharomyces pombe.

Grallert A, et al. (2006 Sep 1). S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner.

Alvarez-Tabarés I, et al. (2007 Oct 15). Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Dodgson J, et al. (2009 Aug). Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Martín-García R, et al. (2009 Nov 1). Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.

Goldstone S, et al. (2010 May 13). Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Duncan CD, et al. (2011 Dec). Widespread cotranslational formation of protein complexes.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Kume K, et al. (2011 Mar). Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

Vandeweyer G, et al. (2012 Jun 8). The contribution of CLIP2 haploinsufficiency to the clinical manifestations of the Williams-Beuren syndrome.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Höög JL, et al. (2013). Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP mutants.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Deng L, et al. (2013 Jun). Compartmentalized nodes control mitotic entry signaling in fission yeast.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Abenza JF, et al. (2014). Dynamics of cell shape inheritance in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Koyano T, et al. (2015 May). Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%