FOG03725
EOG8ZW3T8

sce:TEF1; TEF2

Genes: 45

PomBase Description
translation elongation factor EF-1 alpha Ef1a-a|translation elongation factor EF-1 alpha Ef1a-b|translation elongation factor EF-1 alpha Ef1a-c


AspGD Description
Protein similar to elongation factor 1 alpha


References

Nagata S, et al. (1984 Aug). Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae.

Schirmaier F, et al. (1984 Dec 20). Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae.

Cottrelle P, et al. (1985 Mar 10). Cloning, nucleotide sequence, and expression of one of two genes coding for yeast elongation factor 1 alpha.

Thiele D, et al. (1985 Mar 10). Elongation factor 1 alpha from Saccharomyces cerevisiae. Rapid large-scale purification and molecular characterization.

Nagashima K, et al. (1986). Structure of the two genes coding for polypeptide chain elongation factor 1 alpha (EF-1 alpha) from Saccharomyces cerevisiae.

Sandbaken MG, et al. (1988 Dec). Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae.

Miyazaki M, et al. (1988 Mar). Peptide elongation factor 1 from yeasts: purification and biochemical characterization of peptide elongation factors 1 alpha and 1 beta (gamma) from Saccharomyces carlsbergensis and Schizosaccharomyces pombe.

Sundstrom P, et al. (1990 Apr). Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans.

Cavallius J, et al. (1993 Apr 21). Characterization of yeast EF-1 alpha: non-conservation of post-translational modifications.

Schaaff-Gerstenschläger I, et al. (1993 Oct 1). TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene.

Steiner S, et al. (1994 Feb). Sequence and promoter analysis of the highly expressed TEF gene of the filamentous fungus Ashbya gossypii.

Norbeck J, et al. (1997 Dec). Two-dimensional electrophoretic separation of yeast proteins using a non-linear wide range (pH 3-10) immobilized pH gradient in the first dimension; reproducibility and evidence for isoelectric focusing of alkaline (pI > 7) proteins.

Yanagihara C, et al. (1997 Mar 17). Association of elongation factor 1 alpha and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP.

Mita K, et al. (1997 Mar 18). Comprehensive cloning of Schizosaccharomyces pombe genes encoding translation elongation factors.

Umikawa M, et al. (1998 Apr 16). Interaction of Rho1p target Bni1p with F-actin-binding elongation factor 1alpha: implication in Rho1p-regulated reorganization of the actin cytoskeleton in Saccharomyces cerevisiae.

Gangwani L, et al. (1998 Dec 14). Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.

Kovalchuke O, et al. (1998 Dec 15). Competition and cooperation amongst yeast elongation factors.

Müller S, et al. (1998 Oct). Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica.

Cavallius J, et al. (1998 Oct 30). Site-directed mutagenesis of yeast eEF1A. Viable mutants with altered nucleotide specificity.

Rasmussen C, et al. (1999). Cloning of a Schizosaccharomyces pombe homologue of elongation factor 1 alpha by two-hybrid selection of calmodulin-binding proteins.

Carr-Schmid A, et al. (1999 Oct 15). Mutations in a GTP-binding motif of eukaryotic elongation factor 1A reduce both translational fidelity and the requirement for nucleotide exchange.

Suda M, et al. (1999 Sep). Overproduction of elongation factor 1alpha, an essential translational component, causes aberrant cell morphology by affecting the control of growth polarity in fission yeast.

Grosshans H, et al. (2000 Apr 1). An aminoacylation-dependent nuclear tRNA export pathway in yeast.

Andersen GR, et al. (2000 Nov). Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha.

Zobel-Thropp P, et al. (2000 Nov 24). A novel post-translational modification of yeast elongation factor 1A. Methylesterification at the C terminus.

Munshi R, et al. (2001 Apr). Overexpression of translation elongation factor 1A affects the organization and function of the actin cytoskeleton in yeast.

Andersen GR, et al. (2001 Jun). Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.

Kurtzman CP, et al. (2003 Jun). Phylogenetic relationships among yeasts of the 'Saccharomyces complex' determined from multigene sequence analyses.

Shenton D, et al. (2003 Sep 1). Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae.

Bachand F, et al. (2004 Jul 7). PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits.

Chuang SM, et al. (2005 Jan). Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

McGuire AT, et al. (2007 Jan 24). Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.

Dewez M, et al. (2008 Apr 8). The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.

Calvert ME, et al. (2008 Feb). Phosphorylation by casein kinase 2 regulates Nap1 localization and function.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Lipson RS, et al. (2010 Aug 15). Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Visweswaraiah J, et al. (2011 Oct 21). Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.

Couttas TA, et al. (2012 Apr). Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Ravin NV, et al. (2013 Nov 27). Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Dzialo MC, et al. (2014 Dec 12). A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Hart-Smith G, et al. (2014 Mar 7). Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity.

Jakobsson ME, et al. (2015). Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Hamey JJ, et al. (2016 Jan). Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03726
EOG8ZW3T8

sce:SUP35

Genes: 34

SGD Description
Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)]


PomBase Description
translation release factor class II eRF3


AspGD Description
Suppressor protein 2


References

Kushnirov VV, et al. (1987 May 11). Localization of possible functional domains in sup2 gene product of the yeast Saccharomyces cerevisiae.

Kikuchi Y, et al. (1988 Apr). A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain.

Wilson PG, et al. (1988 Feb 20). SUF12 suppressor protein of yeast. A fusion protein related to the EF-1 family of elongation factors.

Kushnirov VV, et al. (1988 Jun 15). Nucleotide sequence of the SUP2 (SUP35) gene of Saccharomyces cerevisiae.

Stansfield I, et al. (1995 Sep 1). The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae.

Derkatch IL, et al. (1996 Dec). Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae.

Paushkin SV, et al. (1996 Jun 17). Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.

Derkatch IL, et al. (1997 Oct). Genetic and environmental factors affecting the de novo appearance of the [PSI+] prion in Saccharomyces cerevisiae.

Derkatch IL, et al. (2001 Jul 27). Prions affect the appearance of other prions: the story of [PIN(+)].

Nakayashiki T, et al. (2001 Jun). Yeast [PSI+] "prions" that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state.

Cosson B, et al. (2002 May). Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation.

Hosoda N, et al. (2003 Oct 3). Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.

King CY, et al. (2004 Mar 18). Protein-only transmission of three yeast prion strains.

Tanaka M, et al. (2004 Mar 18). Conformational variations in an infectious protein determine prion strain differences.

Amrani N, et al. (2004 Nov 4). A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay.

Kobayashi T, et al. (2004 Oct 29). The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay.

Nelson R, et al. (2005 Jun 9). Structure of the cross-beta spine of amyloid-like fibrils.

Shewmaker F, et al. (2006 Dec 26). Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure.

Keeling KM, et al. (2006 Jul). Tpa1p is part of an mRNP complex that influences translation termination, mRNA deadenylation, and mRNA turnover in Saccharomyces cerevisiae.

Lancaster AK, et al. (2010 Feb). The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Liu W, et al. (2014 Apr 11). In Aspergillus nidulans the suppressors suaA and suaC code for release factors eRF1 and eRF3 and suaD codes for a glutamine tRNA.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03727
EOG8ZW3T8

sce:TUF1

Genes: 33

SGD Description
Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans


PomBase Description
mitochondrial translation elongation factor EF-Tu Tuf1


AspGD Description
Ortholog(s) have GTPase activity, translation elongation factor activity, role in mitochondrial translational elongation and mitochondrion localization


References

Nagata S, et al. (1983 Oct). Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae.

Myers AM, et al. (1985 Aug). Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae.

Branda SS, et al. (1995 Nov 10). Prediction and identification of new natural substrates of the yeast mitochondrial intermediate peptidase.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03728
EOG8ZW3T8

sce:HBS1

Genes: 32

SGD Description
GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication


PomBase Description
elongation factor 1 alpha related protein Hbs1 (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Nelson RJ, et al. (1992 Oct 2). The translation machinery and 70 kd heat shock protein cooperate in protein synthesis.

Carr-Schmid A, et al. (2002 Apr). Novel G-protein complex whose requirement is linked to the translational status of the cell.

Doma MK, et al. (2006 Mar 23). Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Chen L, et al. (2010 Oct). Structure of the Dom34-Hbs1 complex and implications for no-go decay.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%