FOG03729
EOG8ZS7M4
sce:APE1
Genes: 32
EOG8ZS7M4
sce:APE1
Genes: 32
SGD Description
Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
AspGD Description
Ortholog(s) have metalloaminopeptidase activity and extracellular region, fungal-type vacuole localization
References
Matile P, et al. (1971 Mar). A lysosomal aminopeptidase isozyme in differentiating yeast cells and protoplasts.
Metz G, et al. (1976 May 13). Yeast aminopeptidase I. Chemical composition and catalytic properties.
Frey J, et al. (1978 Nov 10). Subcellular localization and levels of aminopeptidases and dipeptidase in Saccharomyces cerevisiae.
Trumbly RJ, et al. (1983 Oct). Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae.
Achstetter T, et al. (1985 Dec). Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiae.
Röhm KH, et al. (1985 Feb 1). Metal binding to yeast aminopeptidase I.
Röhm KH, et al. (1985 May 15). Chloride as allosteric effector of yeast aminopeptidase I.
Chang YH, et al. (1989 Apr 25). Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.
Cueva R, et al. (1989 Dec 18). Yeast vacuolar aminopeptidase yscI. Isolation and regulation of the APE1 (LAP4) structural gene.
Klionsky DJ, et al. (1992 Oct). Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.
Chéret G, et al. (1993 Nov). The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast.
Seguí-Real B, et al. (1995 Nov 15). Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extension.
Oda MN, et al. (1996 Mar). Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
Scott SV, et al. (1996 Oct 29). Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
Baba M, et al. (1997 Dec 29). Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome.
Scott SV, et al. (1997 Jul 14). Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.
Kim J, et al. (1997 May 5). Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway.
Andrei-Selmer C, et al. (2001 Apr 13). A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transport.
Leber R, et al. (2001 Aug 3). Yol082p, a novel CVT protein involved in the selective targeting of aminopeptidase I to the yeast vacuole.
Scott SV, et al. (2001 Jun). Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway.
Shintani T, et al. (2004 Jul 16). Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway.
Adachi W, et al. (2007 Mar 1). Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
Schu P, et al. (2008). Aminopeptidase I enzymatic activity.
Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.
Morales Quinones M, et al. (2012 Mar 23). Propeptide of aminopeptidase 1 protein mediates aggregation and vesicle formation in cytoplasm-to-vacuole targeting pathway.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03730
EOG8ZS7M4
sce:APE4
Genes: 32
EOG8ZS7M4
sce:APE4
Genes: 32
SGD Description
Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
PomBase Description
aspartyl metalloaminopeptidase Aap1
AspGD Description
Ortholog(s) have metalloaminopeptidase activity, role in cellular response to drug, chaperone-mediated protein folding, proteolysis and cytosol, extracellular region, fungal-type vacuole lumen, ribosome localization
References
Kumar A, et al. (2002 Mar 15). Subcellular localization of the yeast proteome.
Yokoyama R, et al. (2006 Jan). Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells.
Idiris A, et al. (2006 Nov). Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe.
Sarry JE, et al. (2007 Aug). Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae.
Lee S, et al. (2009 Dec 31). Aspartyl aminopeptidase of Schizosaccharomyces pombe has a molecular chaperone function.
Idiris A, et al. (2010 Jan). Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway.
Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Mukaiyama H, et al. (2011 Apr). Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe.
Yuga M, et al. (2011 Apr 15). Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae.
Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.
Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG03731
EOG8ZS7M4
sce:absent
Genes: 3
EOG8ZS7M4
sce:absent
Genes: 3
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03732
EOG8ZS7M4
sce:absent
Genes: 2
EOG8ZS7M4
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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