FOG03724
EOG802VC7

sce:CSM3

Genes: 24

SGD Description
Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress


PomBase Description
replication fork protection complex subunit Swi3


AspGD Description
Has domain(s) with predicted role in cell cycle, cellular response to DNA damage stimulus, replication fork protection and nucleus localization


References

Rabitsch KP, et al. (2001 Jul 10). A screen for genes required for meiosis and spore formation based on whole-genome expression.

Mayer ML, et al. (2004 Apr). Identification of protein complexes required for efficient sister chromatid cohesion.

Xu H, et al. (2004 Aug). Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.

Nedelcheva MN, et al. (2005 Apr 1). Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

Archambault V, et al. (2005 Aug). Disruption of mechanisms that prevent rereplication triggers a DNA damage response.

Redon C, et al. (2006 Jan). Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.

Mohanty BK, et al. (2006 Jan 24). The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%