FOG03719
EOG80K6GC

sce:YCK1;YCK2

Genes: 43

SGD Description
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK1 has a paralog, YCK2, that arose from the whole genome duplication|Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK2 has a paralog, YCK1, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Cki1|serine/threonine protein kinase Cki2


AspGD Description
Ortholog(s) have ATP binding, magnesium ion binding, protein serine/threonine kinase activity, protein tyrosine kinase activity


References

Robinson LC, et al. (1992 Jan 1). Yeast casein kinase I homologues: an essential gene pair.

Wang PC, et al. (1992 Mar). Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1.

Iraqui I, et al. (1998 Jan). Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.

Feng Y, et al. (2000 Jul). Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane.

Roth AF, et al. (2002 Oct 14). The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.

Babu P, et al. (2004 Jun 25). Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03720
EOG80K6GC

sce:HRR25

Genes: 36

SGD Description
Protein kinase; involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; phosphorylates the COPII coat; phosphorylates Tif6p which plays a critical role in 60S ribosomal subunit biogenesis; interacts with Sit4p phosphatase; homolog of mammalian casein kinase 1delta (CK1delta)


PomBase Description
serine/threonine protein kinase Hhp1


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity, protein tyrosine kinase activity


References

Hoekstra MF, et al. (1991 Aug 30). HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA.

DeMaggio AJ, et al. (1992 Aug 1). The budding yeast HRR25 gene product is a casein kinase I isoform.

Hoekstra MF, et al. (1994 Aug). Budding and fission yeast casein kinase I isoforms have dual-specificity protein kinase activity.

Dhillon N, et al. (1994 Jun 15). Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair.

Tanaka H, et al. (1999 Feb). Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.

Schäfer T, et al. (2003 Mar 17). The path from nucleolar 90S to cytoplasmic 40S pre-ribosomes.

Petronczki M, et al. (2006 Sep 22). Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Rumpf C, et al. (2010 Jul 1). Casein kinase 1 is required for efficient removal of Rec8 during meiosis I.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Ishiguro T, et al. (2010 May). Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.

Fasolo J, et al. (2011 Apr 1). Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Apostolaki A, et al. (2012 May). Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Hernández-Ortiz P, et al. (2013 Aug). Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in Aspergillus nidulans.

Johnson AE, et al. (2013 Oct 7). CK1 is required for a mitotic checkpoint that delays cytokinesis.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Mahyous Saeyd SA, et al. (2014 Jul). Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Sakuno T, et al. (2015 Jan 26). Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.

Phadnis N, et al. (2015 May). Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.

Ye Q, et al. (2016 Oct 4). Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG03721
EOG80K6GC

sce:absent

Genes: 8

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03722
EOG80K6GC

sce:YCK3

Genes: 6

SGD Description
Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway


References

Wang X, et al. (1996 Oct). Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase.

Sun B, et al. (2004 Mar). The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXPhi adaptin sorting signal.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03723
EOG80K6GC

sce:absent

Genes: 4

PomBase Description
serine/threonine protein kinase Cki3|serine/threonine protein kinase Hhp2


References

Kitamura K, et al. (1998 Jul 3). Identification of a novel casein kinase-1 homolog in fission yeast Schizosaccharomyces pombe.

Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Tanae K, et al. (2012). Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Koyano T, et al. (2015 Dec). Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.

Koyano T, et al. (2015 May). Casein kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and calcineurin in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%