FOG03453
EOG8X3FHP

sce:MSP1

Genes: 34

SGD Description
Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain


PomBase Description
mitochondrial outer membrane ATPase Msp1/Yta4 (predicted)


AspGD Description
Ortholog(s) have role in protein targeting to mitochondrion and mitochondrial outer membrane, peroxisomal membrane localization


References

Lisowsky T, et al. (1992 Mar). Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast.

Nakai M, et al. (1993 Nov 15). Intramitochondrial protein sorting. Isolation and characterization of the yeast MSP1 gene which belongs to a novel family of putative ATPases.

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%

FOG03454
EOG8X3FHP

sce:VPS4

Genes: 33

SGD Description
AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism


PomBase Description
AAA family ATPase Vps4 (predicted)


AspGD Description
Putative vacuolar protein sorting AAA-ATPase; expression decreased by growth on maltose


References

Babst M, et al. (1997 Apr 15). Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p.

Babst M, et al. (1998 Jun 1). The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.

Zahn R, et al. (2001 May). End13p/Vps4p is required for efficient transport from early to late endosomes in Saccharomyces cerevisiae.

Yeo SC, et al. (2003 Oct 1). Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.

Kullas AL, et al. (2004 Dec). Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicans.

Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Tournu H, et al. (2005 Oct). Global role of the protein kinase Gcn2 in the human pathogen Candida albicans.

Lottridge JM, et al. (2006 Apr 18). Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body.

Nickerson DP, et al. (2006 Dec 4). Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes.

Azmi I, et al. (2006 Feb 27). Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.

Xiao J, et al. (2007 Nov 30). Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4.

Obita T, et al. (2007 Oct 11). Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

Stuchell-Brereton MD, et al. (2007 Oct 11). ESCRT-III recognition by VPS4 ATPases.

Lee SA, et al. (2007 Sep). A functional analysis of the Candida albicans homolog of Saccharomyces cerevisiae VPS4.

Rue SM, et al. (2008 Feb). Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting.

Hartmann C, et al. (2008 Mar 21). Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p.

Yu Z, et al. (2008 Mar 21). Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p.

Thomas DP, et al. (2009 Dec 1). A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans.

Lee SA, et al. (2009 Feb). Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence.

Rodríguez-Galán O, et al. (2009 Feb 13). Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III.

Wolf JM, et al. (2010 Aug). The Candida albicans ESCRT pathway makes Rim101-dependent and -independent contributions to pathogenesis.

Hervás-Aguilar A, et al. (2010 Jul). Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway.

Wolf JM, et al. (2010 Mar). Mutational analysis of Candida albicans SNF7 reveals genetically separable Rim101 and ESCRT functions and demonstrates divergence in bro1-domain protein interactions.

Gomez-Raja J, et al. (2012 May). The β-arrestin-like protein Rim8 is hyperphosphorylated and complexes with Rim21 and Rim101 to promote adaptation to neutral-alkaline pH.

Rane HS, et al. (2014). Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03455
EOG8X3FHP

sce:SAP1

Genes: 32

SGD Description
Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system


PomBase Description
AAA family ATPase, unknown biological role


AspGD Description
Ortholog(s) have role in endocytic recycling, filamentous growth and hyphal tip localization


References

Liberzon A, et al. (1996 Jun 10). Association of yeast SAP1, a novel member of the 'AAA' ATPase family of proteins, with the chromatin protein SIN1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03456
EOG8X3FHP

sce:YTA6

Genes: 7

SGD Description
Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress


References

Baker HV, et al. (1986 Nov). Glycolytic gene expression in Saccharomyces cerevisiae: nucleotide sequence of GCR1, null mutants, and evidence for expression.

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03457
EOG8X3FHP

sce:absent

Genes: 1

PomBase Description
AAA family ATPase kink, Knk1


References

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Scheffler K, et al. (2014 Dec 16). Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%