FOG03448
EOG8X69WD

sce:TIM13

Genes: 32

SGD Description
Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane


PomBase Description
TIM22 inner membrane protein import complex subunit Tim13 (predicted)


AspGD Description
Ortholog(s) have protein transporter activity, role in protein import into mitochondrial inner membrane and cytosol, mitochondrial intermembrane space protein transporter complex, nucleus localization


References

Leuenberger D, et al. (1999 Sep 1). Different import pathways through the mitochondrial intermembrane space for inner membrane proteins.

Paschen SA, et al. (2000 Dec 1). The role of the TIM8-13 complex in the import of Tim23 into mitochondria.

Davis AJ, et al. (2000 Sep 18). Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria.

Murphy MP, et al. (2001 Sep). The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex.

Curran SP, et al. (2002 Sep 16). The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins.

Lutz T, et al. (2003 Sep 1). Import of small Tim proteins into the mitochondrial intermembrane space.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03449
EOG8X69WD

sce:TIM9

Genes: 29

SGD Description
Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane


PomBase Description
Tim9-Tim10 complex subunit Tim9 (predicted)


AspGD Description
Ortholog(s) have protein transporter activity, unfolded protein binding activity and role in protein import into mitochondrial inner membrane, protein import into mitochondrial outer membrane, regulation of growth rate


References

Koehler CM, et al. (1998 Nov 16). Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins.

Adam A, et al. (1999 Jan 15). Tim9, a new component of the TIM22.54 translocase in mitochondria.

Endres M, et al. (1999 Jun 15). Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex.

Davis AJ, et al. (2000 Sep 18). Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria.

Luciano P, et al. (2001 Aug 1). Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex.

Murphy MP, et al. (2001 Sep). The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex.

Curran SP, et al. (2002 Mar 1). The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier.

Truscott KN, et al. (2002 Nov). Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex.

Vial S, et al. (2002 Sep 27). Assembly of Tim9 and Tim10 into a functional chaperone.

Leuenberger D, et al. (2003 Mar). The role of Tim9p in the assembly of the TIM22 import complexes.

Lu H, et al. (2004 Apr 30). The structural basis of the TIM10 chaperone assembly.

Wiedemann N, et al. (2004 Apr 30). Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Vergnolle MA, et al. (2005 Aug 26). Distinct domains of small Tims involved in subunit interaction and substrate recognition.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03450
EOG8X69WD

sce:TIM8

Genes: 22

SGD Description
Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome


References

Kurz M, et al. (1999 Jul). Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway.

Leuenberger D, et al. (1999 Sep 1). Different import pathways through the mitochondrial intermembrane space for inner membrane proteins.

Paschen SA, et al. (2000 Dec 1). The role of the TIM8-13 complex in the import of Tim23 into mitochondria.

Davis AJ, et al. (2000 Sep 18). Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria.

Murphy MP, et al. (2001 Sep). The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex.

Curran SP, et al. (2002 Sep 16). The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03451
EOG8X69WD

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03452
EOG8X69WD

sce:absent

Genes: 1

PomBase Description
TIM22 inner membrane protein import complex subunit Tim8 (predicted)


References

Wilhelm BT, et al. (2008 Jun 26). Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%