FOG03458
EOG8WH72V

sce:VMS1

Genes: 33

SGD Description
Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans


PomBase Description
Cdc48p-Npl4p-Vms1p AAA ATPase complex subunit involved in ER associated ubiquitin-dependent protein catabolic process Vms1 (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Böhm S, et al. (1997 Jun 15). Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Heo JM, et al. (2010 Nov 12). A stress-responsive system for mitochondrial protein degradation.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Tran JR, et al. (2011 Feb 18). A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG03459
EOG8WH72V

sce:REI1

Genes: 31

SGD Description
Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network


PomBase Description
ribosome biogenesis protein (predicted)


AspGD Description
Ortholog(s) have sequence-specific DNA binding activity and role in budding cell bud growth, mitotic cell cycle, nucleocytoplasmic transport, ribosomal large subunit biogenesis


References

Böhm S, et al. (1997 Jun 15). Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins.

Iwase M, et al. (2004 Feb). Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae.

Hung NJ, et al. (2006 May). Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae.

Lebreton A, et al. (2006 May 8). A functional network involved in the recycling of nucleocytoplasmic pre-60S factors.

Demoinet E, et al. (2007 Sep). The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Parnell KM, et al. (2009 Jul). Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Meyer AE, et al. (2010 Jan 8). The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.

Greber BJ, et al. (2012 Dec). Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03460
EOG8WH72V

sce:REH1

Genes: 22

SGD Description
Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains


References

Böhm S, et al. (1997 Jun 15). Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins.

Parnell KM, et al. (2009 Jul). Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03461
EOG8CZ913
EOG8WH72V

sce:SNU23

Genes: 30

SGD Description
Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome


PomBase Description
U4/U6 x U5 tri-snRNP complex subunit Snu23


AspGD Description
Ortholog(s) have role in mRNA splicing, via spliceosome and U4/U6 x U5 tri-snRNP complex localization


References

Gottschalk A, et al. (1999 Aug 16). Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.

Stevens SW, et al. (1999 Jun 22). Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.

Stevens SW, et al. (2002 Jan). Composition and functional characterization of the yeast spliceosomal penta-snRNP.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%