FOG03430
EOG8254DS
sce:UBP5;DOA4
Genes: 34
EOG8254DS
sce:UBP5;DOA4
Genes: 34
SGD Description
Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication|Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication
PomBase Description
ubiquitin C-terminal hydrolase Ubp4
References
Papa FR, et al. (1993 Nov 25). The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.
Xiao W, et al. (1994 Nov). UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product.
Singer JD, et al. (1996 Apr). Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism.
Lucero P, et al. (1997 Feb 15). Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4.
Galan JM, et al. (1997 Oct 1). Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein.
Loayza D, et al. (1998 Feb). Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae.
Swaminathan S, et al. (1999 Aug). The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast.
Papa FR, et al. (1999 Mar). Interaction of the Doa4 deubiquitinating enzyme with the yeast 26S proteasome.
Cooper KF, et al. (1999 May). Oxidative stress-induced destruction of the yeast C-type cyclin Ume3p requires phosphatidylinositol-specific phospholipase C and the 26S proteasome.
Springael JY, et al. (1999 May). NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains.
Amerik AY, et al. (2000 Oct). The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways.
Amerik AY, et al. (2000 Sep-Oct). Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae.
Losko S, et al. (2001 Apr). Uptake of the ATP-binding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 Mutant.
Dupré S, et al. (2001 Jul). Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase.
Horak J, et al. (2001 May). Glucose-induced monoubiquitination of the Saccharomyces cerevisiae galactose transporter is sufficient to signal its internalization.
Nikko E, et al. (2003 Dec 12). Permease recycling and ubiquitination status reveal a particular role for Bro1 in the multivesicular body pathway.
Luhtala N, et al. (2004 Aug 30). Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.
Bowers K, et al. (2004 Mar). Protein-protein interactions of ESCRT complexes in the yeast Saccharomyces cerevisiae.
Fiorani P, et al. (2004 May 14). The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons.
Amerik A, et al. (2006 Dec 4). A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function.
Nickerson DP, et al. (2006 Dec 4). Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes.
Rubio-Texeira M, et al. (2006 Jul). Amino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway.
Nikko E, et al. (2007 Aug). Split-ubiquitin two-hybrid assay to analyze protein-protein interactions at the endosome: application to Saccharomyces cerevisiae Bro1 interacting with ESCRT complexes, the Doa4 ubiquitin hydrolase, and the Rsp5 ubiquitin ligase.
Nikko E, et al. (2007 May). Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway.
Richter C, et al. (2007 May 16). Dual mechanisms specify Doa4-mediated deubiquitination at multivesicular bodies.
Kimura Y, et al. (2009 May 1). An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG03431
EOG8254DS
sce:UBP12
Genes: 33
EOG8254DS
sce:UBP12
Genes: 33
SGD Description
Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm
PomBase Description
CSN-associated deubiquitinating enzyme Ubp12
AspGD Description
Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and cytosol, nucleus localization
References
Zhou C, et al. (2003 Apr). Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
Wee S, et al. (2005 Apr). CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
McLean JR, et al. (2011 Mar 4). Survey of the phosphorylation status of the Schizosaccharomyces pombe deubiquitinating enzyme (DUB) family.
Anton F, et al. (2013 Feb 7). Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Álvarez V, et al. (2016 May 6). Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA.
Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30<sup>Fft3</sup> induces nucleosome disassembly to facilitate RNA polymerase II elongation.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03432
EOG8254DS
sce:UBP8
Genes: 33
EOG8254DS
sce:UBP8
Genes: 33
SGD Description
Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B
PomBase Description
SAGA complex ubiquitin C-terminal hydrolase Ubp8
AspGD Description
Ortholog(s) have protein complex scaffold, ubiquitin-specific protease activity and role in RNA splicing, histone H3-K4 methylation, histone H3-K79 methylation, histone deubiquitination
References
Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.
Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.
Daniel JA, et al. (2004 Jan 16). Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription.
Ingvarsdottir K, et al. (2005 Feb). H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.
Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Helmlinger D, et al. (2008 Nov 15). The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
Helmlinger D, et al. (2011 Jun 3). Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Elmore ZC, et al. (2014 Jun 19). Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.
Deng X, et al. (2015 Oct 7). Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.
Zeng M, et al. (2016 Apr 21). CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG03433
EOG8254DS
sce:UBP10
Genes: 30
EOG8254DS
sce:UBP10
Genes: 30
SGD Description
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p, the largest subunit of RNAP I, by mediating its deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p
PomBase Description
ubiquitin C-terminal hydrolase Ubp16
References
Singer MS, et al. (1998 Oct). Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG03434
EOG8254DS
sce:UBP11;UBP7
Genes: 21
EOG8254DS
sce:UBP11;UBP7
Genes: 21
SGD Description
Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication|Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication
References
Ren J, et al. (2007 Jan). Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
10 genes with posterior transmembrane prediction > 50% |
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FOG03435
EOG8254DS
sce:absent
Genes: 2
EOG8254DS
sce:absent
Genes: 2
PomBase Description
ubiquitin C-terminal hydrolase Ubp1
References
Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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