FOG03429
EOG82V718

sce:MMS21

Genes: 28

SGD Description
SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function


PomBase Description
Smc5-6 complex non-SMC subunit 2, SUMO ligase


AspGD Description
Has domain(s) with predicted SUMO transferase activity, zinc ion binding activity


References

McDonald WH, et al. (2003 Nov 14). Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

Pebernard S, et al. (2004 Nov). Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Andrews EA, et al. (2005 Jan). Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.

Sergeant J, et al. (2005 Jan). Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.

Zhao X, et al. (2005 Mar 29). A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

Pebernard S, et al. (2006 Mar). The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Watts FZ, et al. (2007 Dec). The role of Schizosaccharomyces pombe SUMO ligases in genome stability.

Xhemalce B, et al. (2007 Jan 16). Role of SUMO in the dynamics of telomere maintenance in fission yeast.

Outwin EA, et al. (2009 Aug). Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.

Prudden J, et al. (2011 Jun). DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Steinacher R, et al. (2013). Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.

Garg M, et al. (2014 Aug). Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Zilio N, et al. (2014 Sep 15). A novel histone deacetylase complex in the control of transcription and genome stability.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%