FOG03298
EOG8SQVDD

sce:MAG2

Genes: 34

SGD Description
Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1


PomBase Description
ubiquitin-protein ligase E3 implicated in transcription (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Ding DQ, et al. (2000 Mar). Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03299
EOG8SQVDD

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03300
EOG8SQVDD

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03301
EOG8SQVDD

sce:SLX8

Genes: 5

SGD Description
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; null mutants are aneuploid, have a metaphase delay, and spindle defects including: mispositioned spindles, fish hook spindles, and aberrant spindle kinetics; required for maintenance of genome integrity like human ortholog RNF4


References

Mullen JR, et al. (2001 Jan). Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.

Wang Z, et al. (2006 Mar). Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.

Zhang C, et al. (2006 Mar 7). Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.

Ii T, et al. (2007 Nov). Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathway.

Ii T, et al. (2007 Nov 15). The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity.

Uzunova K, et al. (2007 Nov 23). Ubiquitin-dependent proteolytic control of SUMO conjugates.

Xie Y, et al. (2007 Nov 23). The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation.

Burgess RC, et al. (2007 Sep). The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination.

Andersen MP, et al. (2008 Jul). A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

Mullen JR, et al. (2008 Jul 18). Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates.

Nagai S, et al. (2008 Oct 24). Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03302
EOG8SQVDD

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03303
EOG8SQVDD

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%