FOG03085
EOG80ZPGM

sce:HRD1

Genes: 32

SGD Description
Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon


PomBase Description
synviolin family ubiquitin-protein ligase E3, Hrd1


AspGD Description
Putative ubiquitin-protein ligase; expression enhanced by maltose


References

Hampton RY, et al. (1996 Dec). Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

Bordallo J, et al. (1998 Jan). Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.

Bordallo J, et al. (1999 Apr 9). A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae.

Plemper RK, et al. (1999 Nov). Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.

Wilhovsky S, et al. (2000 May). HRD gene dependence of endoplasmic reticulum-associated degradation.

Gardner RG, et al. (2000 Oct 2). Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

Deak PM, et al. (2001 Apr 6). Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation.

Bays NW, et al. (2001 Jan). Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Gardner RG, et al. (2001 Jul). In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Carvalho P, et al. (2006 Jul 28). Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

Gauss R, et al. (2006 May 3). The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.

Horn SC, et al. (2009 Dec 11). Usa1 functions as a scaffold of the HRD-ubiquitin ligase.

Carvalho P, et al. (2010 Nov 12). Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%

FOG03086
EOG80ZPGM

sce:absent

Genes: 28

SGD Description
Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway


References

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03087
EOG80ZPGM

sce:absent

Genes: 16

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%

FOG03088
EOG80ZPGM

sce:absent

Genes: 11

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 11 genes with posterior transmembrane prediction > 50%

FOG03089
EOG80ZPGM

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted zinc ion binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%

FOG03090
EOG80ZPGM

sce:absent

Genes: 7

AspGD Description
Has domain(s) with predicted zinc ion binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG03091
EOG80ZPGM

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG03092
EOG80ZPGM

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted zinc ion binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG03093
EOG80ZPGM

sce:absent

Genes: 5

PomBase Description
E3 ubiquitin-protein ligase, human RNF family homolog|ubiquitin-protein ligase E3 Meu34 (predicted)


AspGD Description
Protein of unknown function


References

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%