FOG03076
EOG870S2Z

sce:ARF1;ARF2

Genes: 39

SGD Description
ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication|ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication


PomBase Description
ADP-ribosylation factor, Arf family Arf1


AspGD Description
Putative ADP-ribosylation factor; expression enhanced by maltose


References

Sewell JL, et al. (1988 Jul). Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

Stearns T, et al. (1990 Dec). ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes.

Amor JC, et al. (2001 Nov 9). Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases.

Trautwein M, et al. (2004 Nov). Arf1p provides an unexpected link between COPI vesicles and mRNA in Saccharomyces cerevisiae.

Gillingham AK, et al. (2004 Oct 25). The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Juneau K, et al. (2007 Jan 30). High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.

Lee SC, et al. (2008 Aug). Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth.

Lee SC, et al. (2008 Jun). Localization and function of ADP ribosylation factor A in Aspergillus nidulans.

Liu Y, et al. (2009 Jan 14). Structure and membrane interaction of myristoylated ARF1.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Liu Y, et al. (2010 Jul). Dynamic structure of membrane-anchored Arf*GTP.

Yu X, et al. (2012 Feb 3). A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03077
EOG870S2Z

sce:SAR1.00

Genes: 33

SGD Description
GTPase, GTP-binding protein of the ARF family; component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity helping in vesicle formation


PomBase Description
ADP-ribosylation factor Sar1


AspGD Description
Small GTPase of the ARF family, likely a component of COPII coat of transport vesicles; complements S. cerevisiae sar1 mutants


References

Nakańo A, et al. (1989 Dec). A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.

Oka T, et al. (1991 Aug). Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport.

d'Enfert C, et al. (1991 Aug). Sec12p-dependent membrane binding of the small GTP-binding protein Sar1p promotes formation of transport vesicles from the ER.

Nishikawa S, et al. (1991 Jul 10). The GTP-binding Sar1 protein is localized to the early compartment of the yeast secretory pathway.

d'Enfert C, et al. (1991 Nov). Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.

Barlowe C, et al. (1993 Jan 15). Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum.

Yoshihisa T, et al. (1993 Mar 5). Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.

Nakano A, et al. (1994 Aug). Mutational analysis of the Sar1 protein, a small GTPase which is essential for vesicular transport from the endoplasmic reticulum.

Oka T, et al. (1994 Feb). Inhibition of GTP hydrolysis by Sar1p causes accumulation of vesicles that are a functional intermediate of the ER-to-Golgi transport in yeast.

Yeung T, et al. (1995 Dec 22). Uncoupled packaging of targeting and cargo molecules during transport vesicle budding from the endoplasmic reticulum.

Bednarek SY, et al. (1995 Dec 29). COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.

Yamanushi T, et al. (1996 Aug). Characterization of yeast sar1 temperature-sensitive mutants, which are defective in protein transport from the endoplasmic reticulum.

Campbell JL, et al. (1997 Feb 4). Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles.

Matsuoka K, et al. (1998 Apr 17). COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes.

Kuehn MJ, et al. (1998 Jan 8). COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.

Springer S, et al. (1998 Jul 31). Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs.

Saito Y, et al. (1998 Oct). Activities of mutant Sar1 proteins in guanine nucleotide binding, GTP hydrolysis, and cell-free transport from the endoplasmic reticulum to the Golgi apparatus.

Matsuoka K, et al. (2000 Apr). The use of liposomes to study COPII- and COPI-coated vesicle formation and membrane protein sorting.

Antonny B, et al. (2001 Jun). Dynamics of the COPII coat with GTP and stable analogues.

Belden WJ, et al. (2001 Nov 16). Distinct roles for the cytoplasmic tail sequences of Emp24p and Erv25p in transport between the endoplasmic reticulum and Golgi complex.

Jiang L, et al. (2002 Mar 30). Functional characterization of the Candida albicans homologue of secretion-associated and Ras-related (Sar1) protein.

Supek F, et al. (2002 Sep 16). Sec16p potentiates the action of COPII proteins to bud transport vesicles.

Bi X, et al. (2002 Sep 19). Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat.

Antonny B, et al. (2003 Apr). Self-assembly of minimal COPII cages.

Pathre P, et al. (2003 Aug 15). Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export.

Sato K, et al. (2004 Jan 9). Reconstitution of coat protein complex II (COPII) vesicle formation from cargo-reconstituted proteoliposomes reveals the potential role of GTP hydrolysis by Sar1p in protein sorting.

Sato K, et al. (2005 Feb). Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis.

Inadome H, et al. (2005 Sep). Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03078
EOG870S2Z

sce:CIN4

Genes: 30

SGD Description
GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog


PomBase Description
GTP-binding protein involved in beta-tubulin folding Alp41


AspGD Description
Putative ADP-ribosylation factor; induced by caspofungin


References

Wolter R, et al. (1994 Nov-Dec). Molecular characterisation of GTP1, a Saccharomyces cerevisiae gene encoding a small GTP-binding protein.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03079
EOG870S2Z

sce:ARL3

Genes: 30

SGD Description
ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1


AspGD Description
Ortholog(s) have GTPase activity, role in Golgi to plasma membrane protein transport, protein localization to organelle and Golgi apparatus, nuclear outer membrane-endoplasmic reticulum membrane network localization


References

Huang CF, et al. (1999 Feb 5). Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae.

Panic B, et al. (2003 Mar 4). The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the Golgi apparatus.

Setty SR, et al. (2003 Mar 4). Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3.

Behnia R, et al. (2004 May). Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p.

Setty SR, et al. (2004 May). Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p.

Lee SC, et al. (2008 Aug). Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03080
EOG870S2Z

sce:ARL1

Genes: 29

SGD Description
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily, similar to ADP-ribosylation factor


AspGD Description
Ortholog(s) have GTPase activity, role in Golgi to plasma membrane protein transport, cellular response to drug, endocytosis, protein targeting to vacuole and cytosol, trans-Golgi network localization


References

Lee FJ, et al. (1997 Dec 5). Characterization of an ADP-ribosylation factor-like 1 protein in Saccharomyces cerevisiae.

Amor JC, et al. (2001 Nov 9). Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases.

Jochum A, et al. (2002 Jul). Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p.

Panic B, et al. (2003 Mar 4). The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the Golgi apparatus.

Setty SR, et al. (2003 Mar 4). Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3.

Lee SC, et al. (2008 Aug). Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03081
EOG870S2Z

sce:ARF3

Genes: 18

SGD Description
Glucose-repressible ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulating cell polarity and invasive growth; also has mRNA binding activity


PomBase Description
ADP-ribosylation factor, Arf family Arf6


AspGD Description
Ortholog(s) have enzyme regulator activity, mRNA binding activity


References

Lee FJ, et al. (1994 Aug 19). Characterization of a glucose-repressible ADP-ribosylation factor 3 (ARF3) from Saccharomyces cerevisiae.

Gillingham AK, et al. (2004 Oct 25). The GTPase Arf1p and the ER to Golgi cargo receptor Erv14p cooperate to recruit the golgin Rud3p to the cis-Golgi.

Lee SC, et al. (2008). ArfB links protein lipidation and endocytosis to polarized growth of Aspergillus nidulans.

Lee SC, et al. (2008 Aug). Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth.

Fujita A, et al. (2008 Feb 1). ADP-ribosylation factor arf6p may function as a molecular switch of new end take off in fission yeast.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Fujita A, et al. (2009 May). Fission yeast syt22 protein, a putative Arf guanine nucleotide exchange factor, is necessary for new end take off.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Fujita A, et al. (2011 Aug). Fission yeast ucp3 gene encodes a putative Arf6 GTPase-activating protein.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Shaw BD, et al. (2011 Jun). A role for endocytic recycling in hyphal growth.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

Eckler AM, et al. (2013). Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Lucena-Agell D, et al. (2015 Jun). Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03082
EOG870S2Z

sce:absent

Genes: 13

AspGD Description
Has domain(s) with predicted GTP binding activity, role in small GTPase mediated signal transduction and intracellular localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03083
EOG870S2Z

sce:absent

Genes: 13

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03084
EOG870S2Z

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%