HOG01183

FOG03067
EOG87PVQN
EOG8K3JB5

sce:NUP116;NUP100

Genes: 35

SGD Description
FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication|FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication

PomBase Description
nucleoporin Nup98 and Nup96

AspGD Description
Ortholog(s) have role in cellular response to DNA damage stimulus and nuclear membrane, nuclear periphery, nuclear pore outer ring, spindle pole body localization

References

Wimmer C, et al. (1992 Dec). A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1.

Wente SR, et al. (1992 Nov). A new family of yeast nuclear pore complex proteins.

Fabre E, et al. (1994 Jul 29). Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.

Iovine MK, et al. (1995 Dec). The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor.

Sharma K, et al. (1996 Jan). Yeast nucleoporin mutants are defective in pre-tRNA splicing.

Bailer SM, et al. (1998 Feb 16). Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.

Seedorf M, et al. (1999 Feb). Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.

Ho AK, et al. (2000 Aug). Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p.

Strässer K, et al. (2000 Aug 21). Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.

Bailer SM, et al. (2000 Aug 4). Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Stage-Zimmermann T, et al. (2000 Nov). Factors affecting nuclear export of the 60S ribosomal subunit in vivo.

Allen NP, et al. (2001 Aug 3). Proteomic analysis of nucleoporin interacting proteins.

Bailer SM, et al. (2001 Dec). The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.

Strawn LA, et al. (2001 Mar 2). The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex.

Allen NP, et al. (2002 Dec). Deciphering networks of protein interactions at the nuclear pore complex.

Bayliss R, et al. (2002 Dec 27). GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.

Tange Y, et al. (2002 Nov 15). An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.

Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.

Denning DP, et al. (2003 Mar 4). Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.

Pyhtila B, et al. (2003 Oct 24). A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex.

Chen XQ, et al. (2004 Apr 30). Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis.

Baï SW, et al. (2004 Jul). The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.

Strawn LA, et al. (2004 Mar). Minimal nuclear pore complexes define FG repeat domains essential for transport.

Thon G, et al. (2005 Dec). The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe.

McGuire AT, et al. (2007 Jan 24). Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Asakawa H, et al. (2010 Nov 9). Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Sampathkumar P, et al. (2012 Aug). Atomic structure of the nuclear pore complex targeting domain of a Nup116 homologue from the yeast, Candida glabrata.

Bilokapic S, et al. (2012 Sep 18). Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Asakawa H, et al. (2014 Mar-Apr). Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.

Hu W, et al. (2015 Nov 27). Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.

Moris N, et al. (2016 Nov 16). A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03068
EOG8K3JB5

sce:NUP57

Genes: 32

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03069
EOG8K3JB5

sce:NUP145

Genes: 29

SGD Description
Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98

References

Fabre E, et al. (1994 Jul 29). Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.

Wente SR, et al. (1994 Jun). NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure.

Sharma K, et al. (1996 Jan). Yeast nucleoporin mutants are defective in pre-tRNA splicing.

Teixeira MT, et al. (1997 Aug 15). Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins.

Teixeira MT, et al. (1999 Nov 5). Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Galy V, et al. (2000 Jan 6). Nuclear pore complexes in the organization of silent telomeric chromatin.

Lutzmann M, et al. (2002 Feb 1). Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins.

Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.

Denning DP, et al. (2003 Mar 4). Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.

Strawn LA, et al. (2004 Mar). Minimal nuclear pore complexes define FG repeat domains essential for transport.

Hsia KC, et al. (2007 Dec 28). Architecture of a coat for the nuclear pore membrane.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03070
EOG8K3JB5

sce:OM45

Genes: 6

SGD Description
Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress

References

Yaffe MP, et al. (1989 Dec 15). The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Hoppins S, et al. (2011 Oct 17). A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03071
EOG8K3JB5

sce:absent

Genes: 4

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03072
EOG8K3JB5

sce:absent

Genes: 4

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03073
EOG8K3JB5
EOG8TX988

sce:absent

Genes: 2

AspGD Description
Putative alcohol dehydrogenase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03074
EOG8K3JB5

sce:absent

Genes: 2

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03075
EOG8K3JB5

sce:absent

Genes: 13

PomBase Description
Schizosaccharomyces specific protein

AspGD Description
Ortholog of Neosartorya fischeri NRRL 181 : NFIA_114510, Aspergillus wentii : Aspwe1_0173818, Aspwe1_0175438, Aspergillus clavatus NRRL 1 : ACLA_065760 and Aspergillus sydowii : Aspsy1_0049549|Ortholog of A. nidulans FGSC A4 : AN9521, AN0790, A. fumigatus Af293 : Afu5g03750, A. oryzae RIB40 : AO090102000585 and Aspergillus wentii : Aspwe1_0174463

References

Lane S, et al. (2001 Dec 28). DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans.

Karababa M, et al. (2004 Aug). Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.

Bensen ES, et al. (2004 Dec). Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.

Oberholzer U, et al. (2004 Oct). Functional characterization of myosin I tail regions in Candida albicans.

Enjalbert B, et al. (2006 Feb). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.

Dib L, et al. (2008 Jun). The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.

Hao B, et al. (2009 Apr). Candida albicans RFX2 encodes a DNA binding protein involved in DNA damage responses, morphogenesis, and virulence.

Shirtliff ME, et al. (2009 Jun). Farnesol-induced apoptosis in Candida albicans.

Alonso-Monge R, et al. (2010 Jul). The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans.

Hernáez ML, et al. (2010 May 7). Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach.

Synnott JM, et al. (2010 Nov). Regulation of the hypoxic response in Candida albicans.

Herrero S, et al. (2011 May). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore.

Cleary IA, et al. (2012 Jun). Investigating the function of Ddr48p in Candida albicans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt

Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%