FOG03058
EOG8RR52R

sce:RHO1

Genes: 40

SGD Description
GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)


PomBase Description
Rho family GTPase Rho1|Rho family GTPase Rho5


AspGD Description
Ras GTPase


References

Madaule P, et al. (1987 Feb). Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

Myers AM, et al. (1987 Mar 5). Assembly of the mitochondrial membrane system. MRP1 and MRP2, two yeast nuclear genes coding for mitochondrial ribosomal proteins.

Yamochi W, et al. (1994 Jun). Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.

Wang T, et al. (1995 Aug). The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.

Nonaka H, et al. (1995 Dec 1). A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

Drgonová J, et al. (1996 Apr 12). Rho1p, a yeast protein at the interface between cell polarization and morphogenesis.

Qadota H, et al. (1996 Apr 12). Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.

Kamada Y, et al. (1996 Apr 19). Activation of yeast protein kinase C by Rho1 GTPase.

Ozaki K, et al. (1996 May 1). Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

Kohno H, et al. (1996 Nov 15). Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.

Arellano M, et al. (1996 Sep 2). Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.

Kondoh O, et al. (1997 Dec). Cloning of the RHO1 gene from Candida albicans and its regulation of beta-1,3-glucan synthesis.

Schmidt A, et al. (1997 Feb 21). The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

Koch G, et al. (1997 Jul 24). Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae.

Nakano K, et al. (1997 Nov). The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe.

Arellano M, et al. (1997 Oct). Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton.

Alberts AS, et al. (1998 Apr 10). Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

Arellano M, et al. (1998 Sep). Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.

Arellano M, et al. (1999 Oct). Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Cullen CF, et al. (2000 Aug). A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.

Calonge TM, et al. (2000 Dec). Schizosaccharomyces pombe rho2p GTPase regulates cell wall alpha-glucan biosynthesis through the protein kinase pck2p.

Sayers LG, et al. (2000 Jan). Rho-dependence of Schizosaccharomyces pombe Pck2.

Guo W, et al. (2001 Apr). Spatial regulation of the exocyst complex by Rho1 GTPase.

Nakano K, et al. (2001 Dec). Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe.

Saka A, et al. (2001 Dec 7). Complementing yeast rho1 mutation groups with distinct functional defects.

Wendland J, et al. (2001 Feb). Cell polarity and hyphal morphogenesis are controlled by multiple rho-protein modules in the filamentous ascomycete Ashbya gossypii.

Watanabe D, et al. (2001 Jul). Yeast Lrg1p acts as a specialized RhoGAP regulating 1,3-beta-glucan synthesis.

Roumanie O, et al. (2001 Oct 5). Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae.

Schmelzle T, et al. (2002 Mar). Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast.

Tolliday N, et al. (2002 Oct 29). Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis.

Schmidt A, et al. (2002 Sep). The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae.

Iwaki N, et al. (2003 Dec 12). Role of guanine nucleotide exchange factors for Rho family GTPases in the regulation of cell morphology and actin cytoskeleton in fission yeast.

Yang P, et al. (2003 Dec 5). The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe.

Calonge TM, et al. (2003 Jan). Rga5p is a specific Rho1p GTPase-activating protein that regulates cell integrity in Schizosaccharomyces pombe.

Bar EE, et al. (2003 Jun 13). Gbetagamma recruits Rho1 to the site of polarized growth during mating in budding yeast.

Dong Y, et al. (2003 Jun 23). Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast.

Valdivia RH, et al. (2003 Sep 2). The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Tajadura V, et al. (2004 Dec 1). Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.

Marelli M, et al. (2004 Dec 20). Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane.

Guest GM, et al. (2004 Jan). Aspergillus nidulans RhoA is involved in polar growth, branching, and cell wall synthesis.

Fitch PG, et al. (2004 Oct). Lrg1p Is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast.

Palmer CP, et al. (2005 Apr 1). A microbial TRP-like polycystic-kidney-disease-related ion channel gene.

Mutoh T, et al. (2005 Dec). Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.

Morrell-Falvey JL, et al. (2005 Dec 1). Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p.

Santos B, et al. (2005 Oct). Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.

Nakano K, et al. (2005 Sep 26). Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast.

García P, et al. (2006 Apr). Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.

Jin QW, et al. (2006 Apr). A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Rincón SA, et al. (2006 Mar). Fission yeast Rho5p GTPase is a functional paralogue of Rho1p that plays a role in survival of spores and stationary-phase cells.

Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.

Pinar M, et al. (2008 Apr). Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.

Villar-Tajadura MA, et al. (2008 Nov). Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.

Binder U, et al. (2010 Jan). The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans.

Wu JQ, et al. (2010 Nov). Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Cruz S, et al. (2013 Oct). The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.

Viana RA, et al. (2013 Oct). Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Zhu YH, et al. (2013 Oct). Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.

Sánchez-Mir L, et al. (2014). Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.

Muñoz S, et al. (2014 Apr). The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Alcaide-Gavilán M, et al. (2014 Feb). Feedback regulation of SIN by Etd1 and Rho1 in fission yeast.

Doi A, et al. (2015 Apr). Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Davidson R, et al. (2015 Feb 1). Regulation of Rho-GEF Rgf3 by the arrestin Art1 in fission yeast cytokinesis.

Liu Y, et al. (2016 Aug 15). Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03059
EOG8RR52R

sce:RHO2

Genes: 34

SGD Description
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly


PomBase Description
Rho family GTPase Rho2


AspGD Description
Putative GTP-binding protein; induced by caspofungin


References

Madaule P, et al. (1987 Feb). Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

Hirata D, et al. (1998 Jan). Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.

Arellano M, et al. (1999 Oct). Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Calonge TM, et al. (2000 Dec). Schizosaccharomyces pombe rho2p GTPase regulates cell wall alpha-glucan biosynthesis through the protein kinase pck2p.

Steinmetz LM, et al. (2002 Mar 21). Dissecting the architecture of a quantitative trait locus in yeast.

Iwaki N, et al. (2003 Dec 12). Role of guanine nucleotide exchange factors for Rho family GTPases in the regulation of cell morphology and actin cytoskeleton in fission yeast.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Ma Y, et al. (2006 Dec). Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.

Roth AF, et al. (2006 Jun 2). Global analysis of protein palmitoylation in yeast.

Villar-Tajadura MA, et al. (2008 Nov). Rga2 is a Rho2 GAP that regulates morphogenesis and cell integrity in S. pombe.

Calvo IA, et al. (2009 Aug 12). Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Soto T, et al. (2010 Apr 9). Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Viana RA, et al. (2013 Oct). Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Sánchez-Mir L, et al. (2014). Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sánchez-Mir L, et al. (2014 Jul). Rho2 palmitoylation is required for plasma membrane localization and proper signaling to the fission yeast cell integrity mitogen- activated protein kinase pathway.

Kanda Y, et al. (2016 Aug 15). Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.

Liu Y, et al. (2016 Aug 15). Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Revilla-Guarinos MT, et al. (2016 Mar 9). Rga6 is a Fission Yeast Rho GAP Involved in Cdc42 Regulation of Polarized Growth.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03060
EOG8RR52R

sce:CDC42

Genes: 34

SGD Description
Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins


PomBase Description
Rho family GTPase Cdc42


AspGD Description
Rho GTPase


References

Johnson DI, et al. (1990 Jul). Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

Stevenson BJ, et al. (1995 Dec 1). Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.

Miller PJ, et al. (1997 May). Characterization of the Saccharomyces cerevisiae cdc42-1ts allele and new temperature-conditional-lethal cdc42 alleles.

Wendland J, et al. (2001 Feb). Cell polarity and hyphal morphogenesis are controlled by multiple rho-protein modules in the filamentous ascomycete Ashbya gossypii.

Boyce KJ, et al. (2001 Jun). The CDC42 homolog of the dimorphic fungus Penicillium marneffei is required for correct cell polarization during growth but not development.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Virag A, et al. (2007 Dec). Regulation of hyphal morphogenesis by cdc42 and rac1 homologues in Aspergillus nidulans.

Gao XD, et al. (2007 Jul). Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.

Semighini CP, et al. (2008 Aug). Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen species.

Fischer R, et al. (2008 May). Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Si H, et al. (2010 May). Regulation of septum formation by the Bud3-Rho4 GTPase module in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03061
EOG8RR52R

sce:RHO3

Genes: 33

SGD Description
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p


PomBase Description
Rho family GTPase Rho3


AspGD Description
Rho GTPase


References

Matsui Y, et al. (1992 Dec). Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.

Matsui Y, et al. (1992 May 1). Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae.

Wendland J, et al. (2001 Feb). Cell polarity and hyphal morphogenesis are controlled by multiple rho-protein modules in the filamentous ascomycete Ashbya gossypii.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03062
EOG8RR52R
EOG8XKSTP

sce:RHO4

Genes: 19

SGD Description
Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi


References

Matsui Y, et al. (1992 Dec). Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.

Matsui Y, et al. (1992 May 1). Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae.

Chow TY, et al. (1992 Oct 11). Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity.

Whiteway M, et al. (1992 Oct 15). Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

Wendland J, et al. (2000 Jan 25). PCR-based gene targeting in the filamentous fungus Ashbya gossypii.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03063
EOG8RR52R

sce:absent

Genes: 17

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03064
EOG8RR52R

sce:absent

Genes: 9

AspGD Description
Rho GTPase involved in regulation of cell polarity


References

Virag A, et al. (2007 Dec). Regulation of hyphal morphogenesis by cdc42 and rac1 homologues in Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Semighini CP, et al. (2008 Aug). Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen species.

Fischer R, et al. (2008 May). Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Si H, et al. (2010 May). Regulation of septum formation by the Bud3-Rho4 GTPase module in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03065
EOG8RR52R

sce:absent

Genes: 7

PomBase Description
Rho family GTPase Rho4


AspGD Description
Rho GTPase


References

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Si H, et al. (2010 May). Regulation of septum formation by the Bud3-Rho4 GTPase module in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03066
EOG8RR52R

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%