FOG03048
EOG8TQJWB
sce:NHP6B;NHP6A
Genes: 36
EOG8TQJWB
sce:NHP6B;NHP6A
Genes: 36
SGD Description
High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication|High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
PomBase Description
High-mobility group non-histone chromatin protein (predicted)
AspGD Description
Ortholog(s) have DNA binding, bending, sequence-specific DNA binding activity
References
Kolodrubetz D, et al. (1990 Feb 25). Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1.
Tercero JC, et al. (1992 Oct 5). Localized mutagenesis and evidence for post-transcriptional regulation of MAK3. A putative N-acetyltransferase required for double-stranded RNA virus propagation in Saccharomyces cerevisiae.
Paull TT, et al. (1995 Apr 14). DNA looping by Saccharomyces cerevisiae high mobility group proteins NHP6A/B. Consequences for nucleoprotein complex assembly and chromatin condensation.
Paull TT, et al. (1996 Nov 1). Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro.
Yen YM, et al. (1998 Feb 20). Determinants of DNA binding and bending by the Saccharomyces cerevisiae high mobility group protein NHP6A that are important for its biological activities. Role of the unique N terminus and putative intercalating methionine.
Allain FH, et al. (1999 May 4). Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding.
Moreira JM, et al. (2000 Dec 15). Chromatin-mediated transcriptional regulation by the yeast architectural factors NHP6A and NHP6B.
Kruppa M, et al. (2001 Feb). Nhp6, an HMG1 protein, functions in SNR6 transcription by RNA polymerase III in S. cerevisiae.
Yen YM, et al. (2001 Jul). Nuclear localization of the Saccharomyces cerevisiae HMG protein NHP6A occurs by a Ran-independent nonclassical pathway.
Formosa T, et al. (2001 Jul 2). Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.
Brewster NK, et al. (2001 May). A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription.
Lopez S, et al. (2001 May). High-mobility-group proteins NHP6A and NHP6B participate in activation of the RNA polymerase III SNR6 gene.
Masse JE, et al. (2002 Oct 18). The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding.
Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.
Mason PB, et al. (2003 Nov). The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.
Ruone S, et al. (2003 Nov 14). Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes.
Kim M, et al. (2004 Jan 28). Transitions in RNA polymerase II elongation complexes at the 3' ends of genes.
Rhoades AR, et al. (2004 May). Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6.
Skoko D, et al. (2004 Nov 2). Micromechanical analysis of the binding of DNA-bending proteins HMGB1, NHP6A, and HU reveals their ability to form highly stable DNA-protein complexes.
Biswas D, et al. (2005 Jul). The yeast FACT complex has a role in transcriptional initiation.
Kassavetis GA, et al. (2006 Mar 17). Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo.
Juneau K, et al. (2007 Jan 30). High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Karácsony Z, et al. (2014 Oct). A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination.
Gal C, et al. (2016 Jan). Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03049
EOG8TQJWB
sce:NHP10
Genes: 23
EOG8TQJWB
sce:NHP10
Genes: 23
SGD Description
Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins
References
Lu J, et al. (1996 Dec 27). Characterization of a high mobility group 1/2 homolog in yeast.
Shen X, et al. (2003 Jul). Involvement of actin-related proteins in ATP-dependent chromatin remodeling.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03050
EOG8TQJWB
sce:HMO1
Genes: 21
EOG8TQJWB
sce:HMO1
Genes: 21
SGD Description
Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia
References
Lu J, et al. (1996 Dec 27). Characterization of a high mobility group 1/2 homolog in yeast.
Dolinski KJ, et al. (1999 Mar). Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
Alekseev SY, et al. (2002 Apr 29). HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae.
Gadal O, et al. (2002 Oct 15). Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system.
Lavoie H, et al. (2010 Mar 9). Evolutionary tinkering with conserved components of a transcriptional regulatory network.
Nobile CJ, et al. (2012 Jan 20). A recently evolved transcriptional network controls biofilm development in Candida albicans.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG03051
EOG8TQJWB
sce:IXR1
Genes: 6
EOG8TQJWB
sce:IXR1
Genes: 6
SGD Description
Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication
References
Brown SJ, et al. (1993 Jul 30). Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin.
Lambert JR, et al. (1994 Jul 19). The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03052
EOG87M0GG
EOG8TQJWB
sce:absent
Genes: 3
EOG87M0GG
EOG8TQJWB
sce:absent
Genes: 3
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG03053
EOG8D51J6
sce:absent
Genes: 3
EOG8D51J6
sce:absent
Genes: 3
AspGD Description
Ortholog(s) have DNA binding, bending, double-stranded DNA binding, four-way junction DNA binding, sequence-specific DNA binding activity
References
Karácsony Z, et al. (2014 Oct). A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03054
EOG8TQJWB
sce:absent
Genes: 2
EOG8TQJWB
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG03055
EOG8D51J6
EOG8TQJWB
sce:absent
Genes: 2
EOG8D51J6
EOG8TQJWB
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03056
EOG8TQJWB
sce:absent
Genes: 2
EOG8TQJWB
sce:absent
Genes: 2
PomBase Description
transcription factor Ste11
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG03057
EOG8TQJWB
sce:ABF2
Genes: 16
EOG8TQJWB
sce:ABF2
Genes: 16
SGD Description
Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication
PomBase Description
HMG box protein Hmo1|cytosine-mismatch binding protein 1
AspGD Description
Ortholog(s) have role in ascospore formation, asexual sporulation resulting in formation of a cellular spore and mitochondrion, nucleus localization|Ortholog of A. nidulans FGSC A4 : AN3667, A. fumigatus Af293 : Afu4g12410, A. oryzae RIB40 : AO090009000453, Aspergillus wentii : Aspwe1_0166557 and Aspergillus sydowii : Aspsy1_1055875
References
Diffley JF, et al. (1991 Sep 1). A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria.
Fleck O, et al. (1998 Nov 13). The high mobility group domain protein Cmb1 of Schizosaccharomyces pombe binds to cytosines in base mismatches and opposite chemically altered guanines.
Cho JH, et al. (1998 Oct). A novel DNA-binding protein bound to the mitochondrial inner membrane restores the null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae.
Sassoon J, et al. (2001 Jun 22). Biochemical characterization of the structure-specific DNA-binding protein Cmb1 from Schizosaccharomyces pombe.
Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.
Kunz C, et al. (2003 Jun 1). Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage.
Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Vanoosthuyse V, et al. (2014 Jun). CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
Karácsony Z, et al. (2014 Oct). A dually located multi-HMG-box protein of Aspergillus nidulans has a crucial role in conidial and ascospore germination.
Karácsony Z, et al. (2015 Oct). Further characterization of the role of the mitochondrial high-mobility group box protein in the intracellular redox environment of Aspergillus nidulans.
Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
