FOG03039
EOG89W0WM
EOG8VT4D0
EOG8X69QP

sce:MSS116

Genes: 34

SGD Description
Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate


PomBase Description
mitochondrial ATP-dependent RNA helicase Mss116 (predicted)


AspGD Description
Ortholog(s) have mitochondrion localization|Ortholog(s) have ATP-dependent RNA helicase activity, RNA strand annealing activity, mRNA binding activity and role in Group I intron splicing, Group II intron splicing, RNA folding, transcription elongation from mitochondrial promoter


References

Séraphin B, et al. (1989 Jan 5). Mitochondrial splicing requires a protein from a novel helicase family.

Niemer I, et al. (1995 Sep 11). Overexpression of DEAD box protein pMSS116 promotes ATP-dependent splicing of a yeast group II intron in vitro.

Minczuk M, et al. (2002 Nov). Overexpressed yeast mitochondrial putative RNA helicase Mss116 partially restores proper mtRNA metabolism in strains lacking the Suv3 mtRNA helicase.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Huang HR, et al. (2005 Jan 4). The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03040
EOG8VT4D0

sce:DBP10

Genes: 33

SGD Description
Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis


PomBase Description
ATP-dependent RNA helicase Dbp10 (predicted)


AspGD Description
Ortholog(s) have nucleolus localization


References

Burger F, et al. (2000 Jun 15). Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis.

Horsey EW, et al. (2004 May). Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG03041
EOG8VT4D0

sce:HCA4

Genes: 33

SGD Description
DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis


PomBase Description
ATP-dependent RNA helicase Hca4 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Chang TH, et al. (1990 Feb). Identification of five putative yeast RNA helicase genes.

Liang WQ, et al. (1997 Jul). The rRNA-processing function of the yeast U14 small nucleolar RNA can be rescued by a conserved RNA helicase-like protein.

Kos M, et al. (2005 Oct 7). The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae.

Bohnsack MT, et al. (2008 Dec). Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase.

Garcia I, et al. (2008 Nov 25). Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03042
EOG8VT4D0

sce:DBP7

Genes: 33

SGD Description
Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions


PomBase Description
ATP-dependent RNA helicase Dbp7 (predicted)


AspGD Description
Ortholog(s) have nucleolus localization


References

Daugeron MC, et al. (1998 May). Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly.

Walsh DW, et al. (2002 Aug). Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG03043
EOG8VT4D0

sce:DBP8

Genes: 33

SGD Description
ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p


PomBase Description
ATP-dependent RNA helicase Dbp8 (predicted)


AspGD Description
Ortholog(s) have nucleolus localization


References

Daugeron MC, et al. (2001 Mar 1). Characterization and mutational analysis of yeast Dbp8p, a putative RNA helicase involved in ribosome biogenesis.

Granneman S, et al. (2006). The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03044
EOG8VT4D0

sce:DRS1

Genes: 33

SGD Description
Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles


PomBase Description
ATP-dependent RNA helicase Ddx27/Drs1 (predicted)


AspGD Description
Ortholog(s) have nucleolus localization


References

Ripmaster TL, et al. (1992 Dec 1). A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly.

Ripmaster TL, et al. (1993 Dec). DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae.

Adams CC, et al. (2002 Feb). Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.

Horsey EW, et al. (2004 May). Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG03045
EOG8VT4D0

sce:HAS1

Genes: 33

SGD Description
ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles


PomBase Description
ATP-dependent RNA helicase Has1 (predicted)


AspGD Description
Ortholog(s) have ATP-dependent RNA helicase activity, RNA binding activity


References

Nislow C, et al. (1997 Dec). SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Ubersax JA, et al. (2003 Oct 23). Targets of the cyclin-dependent kinase Cdk1.

Emery B, et al. (2004 Apr). Has1p, a member of the DEAD-box family, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae.

Mnaimneh S, et al. (2004 Jul 9). Exploration of essential gene functions via titratable promoter alleles.

Horsey EW, et al. (2004 May). Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation.

Rocak S, et al. (2005). Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs.

De Marchis ML, et al. (2005 Apr). Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG03046
EOG8VT4D0

sce:RRP3

Genes: 33

SGD Description
Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity


PomBase Description
ATP-dependent RNA helicase Rrp3 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

O'Day CL, et al. (1996 Aug 15). 18S rRNA processing requires the RNA helicase-like protein Rrp3.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Granneman S, et al. (2006 Feb). Comprehensive mutational analysis of yeast DEXD/H box RNA helicases required for small ribosomal subunit synthesis.

Garcia I, et al. (2008 Nov 25). Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Garcia I, et al. (2012 Dec 18). Duplex destabilization by four ribosomal DEAD-box proteins.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03047
EOG8VT4D0

sce:SPB4

Genes: 33

SGD Description
Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients


PomBase Description
ATP-dependent RNA helicase Spb4 (predicted)


AspGD Description
Ortholog(s) have role in assembly of large subunit precursor of preribosome, maturation of LSU-rRNA, ribosomal large subunit assembly and 90S preribosome, nucleolus, nucleoplasm, preribosome, large subunit precursor localization


References

Sachs AB, et al. (1990 Mar 2). Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.

de la Cruz J, et al. (1998 Oct). Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Christians JK, et al. (2011 Apr 29). Quantitative trait locus (QTL) mapping reveals a role for unstudied genes in Aspergillus virulence.

García-Gómez JJ, et al. (2011 Oct). Dynamics of the putative RNA helicase Spb4 during ribosome assembly in Saccharomyces cerevisiae.

Talkish J, et al. (2012 Sep 1). Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae.

Ohmayer U, et al. (2013). Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

García-Gómez JJ, et al. (2015). Dynamics of the Spb4 interactome monitored by affinity purification.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 16 genes with posterior transmembrane prediction > 50%