FOG03028
EOG81NS34
EOG8MCVN8

sce:KIP1;CIN8

Genes: 43

SGD Description
Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions|Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation


PomBase Description
kinesin-like protein Cut7


AspGD Description
Ortholog(s) have microtubule binding, microtubule motor activity and role in mitotic spindle disassembly, mitotic spindle midzone assembly, spindle pole body separation


References

Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.

Enos AP, et al. (1990 Mar 23). Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans.

Enos AP, et al. (1991). Kinesin-like proteins of Aspergillus nidulans.

Le Guellec R, et al. (1991 Jun). Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein.

Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.

Saunders WS, et al. (1992 Aug 7). Kinesin-related proteins required for structural integrity of the mitotic spindle.

Hoyt MA, et al. (1992 Jul). Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly.

Roof DM, et al. (1992 Jul). Kinesin-related proteins required for assembly of the mitotic spindle.

Doonan JH, et al. (1992 Nov). Cell division in Aspergillus.

O'Connell MJ, et al. (1993 Jan). Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans.

Okano K, et al. (1994 Nov). cDNA structure and characterization of a kinesin-like protein from the silkworm Bombyx mori.

Rousselet G, et al. (1995 Feb 13). A second nitrogen permease regulator in Saccharomyces cerevisiae.

Kashina AS, et al. (1997 Jul 24). The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation.

Drummond DR, et al. (1998 Apr). Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins.

Efimov VP, et al. (1998 May). A screen for dynein synthetic lethals in Aspergillus nidulans identifies spindle assembly checkpoint genes and other genes involved in mitosis.

Stock MF, et al. (2003 Dec 26). The kinesin family member BimC contains a second microtubule binding region attached to the N terminus of the motor domain.

DeBonis S, et al. (2003 Jan 21). Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.

Xiang X, et al. (2004 Apr). Nuclear migration and positioning in filamentous fungi.

Rischitor PE, et al. (2004 Jun). The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.

Bevan DR, et al. (2005 Nov). Application of molecular modeling to analysis of inhibition of kinesin motor proteins of the BimC subfamily by monastrol and related compounds.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Wang B, et al. (2015 Sep). The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03029
EOG81NS34

sce:KIP2

Genes: 34

SGD Description
Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle


PomBase Description
kinesin-like protein Tea2


AspGD Description
Ortholog(s) have ATP-dependent microtubule motor activity, plus-end-directed, microtubule plus-end binding, plus-end directed microfilament motor activity


References

Roof DM, et al. (1992 Jul). Kinesin-related proteins required for assembly of the mitotic spindle.

Suelmann R, et al. (2000 May). Nuclear migration in fungi--different motors at work.

Xiang X, et al. (2004 Apr). Nuclear migration and positioning in filamentous fungi.

Rischitor PE, et al. (2004 Jun). The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.

Konzack S, et al. (2005 Feb). The role of the kinesin motor KipA in microtubule organization and polarized growth of Aspergillus nidulans.

Efimov VP, et al. (2006 Apr). CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans.

Enke C, et al. (2007 Mar). Aspergillus nidulans Dis1/XMAP215 protein AlpA localizes to spindle pole bodies and microtubule plus ends and contributes to growth directionality.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Takeshita N, et al. (2008 Jan). Apical sterol-rich membranes are essential for localizing cell end markers that determine growth directionality in the filamentous fungus Aspergillus nidulans.

Fischer R, et al. (2008 May). Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Zekert N, et al. (2009 Jan). The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules.

Higashitsuji Y, et al. (2009 Jul). The cell end marker protein TeaC is involved in growth directionality and septation in Aspergillus nidulans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Chen S, et al. (2010 Mar). Localization and function of calmodulin in live-cells of Aspergillus nidulans.

Herrero S, et al. (2011 May). The Aspergillus nidulans CENP-E kinesin motor KipA interacts with the fungal homologue of the centromere-associated protein CENP-H at the kinetochore.

Schunck T, et al. (2011 Oct). The Aspergillus nidulans CENP-E kinesin KipA is able to dimerize and to move processively along microtubules.

Egan MJ, et al. (2012 Dec). Microtubule-based transport in filamentous fungi.

Takeshita N, et al. (2013 Dec 1). The cell-end marker TeaA and the microtubule polymerase AlpA contribute to microtubule guidance at the hyphal tip cortex of Aspergillus nidulans to provide polarity maintenance.

Herrero S, et al. (2014 Aug). F-box protein RcyA controls turnover of the kinesin-7 motor KipA in Aspergillus nidulans.

Wang B, et al. (2015 Sep). The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG03030
EOG81NS34

sce:absent

Genes: 7

AspGD Description
Ortholog(s) have role in mitochondrion transport along microtubule, vesicle transport along microtubule and cytoplasmic microtubule, cytoplasmic vesicle, early endosome localization


References

Rischitor PE, et al. (2004 Jun). The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.

Zekert N, et al. (2009 Jan). The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules.

Zhang J, et al. (2011). Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport.

Seidel C, et al. (2012). The Aspergillus nidulans kinesin-3 tail is necessary and sufficient to recognize modified microtubules.

Etxebeste O, et al. (2013). Cytoplasmic dynamics of the general nuclear import machinery in apically growing syncytial cells.

Seidel C, et al. (2013 Jul). Neurospora crassa NKIN2, a kinesin-3 motor, transports early endosomes and is required for polarized growth.

Takeshita N, et al. (2015). Transportation of Aspergillus nidulans Class III and V Chitin Synthases to the Hyphal Tips Depends on Conventional Kinesin.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03031
EOG81NS34
EOG8Q2BXV

sce:absent

Genes: 26

PomBase Description
kinesin-like protein Klp8


AspGD Description
Ortholog(s) have microtubule motor activity, protein homodimerization activity and cell tip, kinesin complex, medial cortical node, mitotic spindle pole body, nucleus localization


References

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Moseley JB, et al. (2009 Jun 11). A spatial gradient coordinates cell size and mitotic entry in fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Deng L, et al. (2014 Feb 17). Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Akamatsu M, et al. (2017 Nov 7). Analysis of interphase node proteins in fission yeast by quantitative and superresolution fluorescence microscopy.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03032
EOG81NS34

sce:KIP3

Genes: 33

SGD Description
Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone


PomBase Description
kinesin-like protein Klp5|kinesin-like protein Klp6


AspGD Description
Ortholog(s) have ATP-dependent microtubule motor activity, plus-end-directed activity


References

Xiang X, et al. (2004 Apr). Nuclear migration and positioning in filamentous fungi.

Rischitor PE, et al. (2004 Jun). The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.

Konzack S, et al. (2005 Feb). The role of the kinesin motor KipA in microtubule organization and polarized growth of Aspergillus nidulans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

de Castro Pimentel Figueiredo B, et al. (2011 Feb). The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.

Egan MJ, et al. (2012 Dec). Microtubule-based transport in filamentous fungi.

Cederquist GY, et al. (2012 Dec 15). An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03033
EOG81NS34

sce:KAR3

Genes: 31

SGD Description
Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate


PomBase Description
minus-end directed microtubule motor kinesin-14, Klp2|minus-end directed microtubule motor, kinesin Pkl1


AspGD Description
Ortholog(s) have ATP-dependent microtubule motor activity, minus-end-directed activity


References

Meluh PB, et al. (1990 Mar 23). KAR3, a kinesin-related gene required for yeast nuclear fusion.

O'Connell MJ, et al. (1993 Jan). Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans.

Hoyt MA, et al. (1993 Sep). Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations.

Endow SA, et al. (1994 Jun 1). Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

Gulick AM, et al. (1998 Feb 17). X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution.

Manning BD, et al. (1999 Mar 22). Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p.

Shanks RM, et al. (2001 Nov). The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae.

Prigozhina NL, et al. (2001 Oct). Gamma-tubulin and the C-terminal motor domain kinesin-like protein, KLPA, function in the establishment of spindle bipolarity in Aspergillus nidulans.

Rischitor PE, et al. (2004 Jun). The Kip3-like kinesin KipB moves along microtubules and determines spindle position during synchronized mitoses in Aspergillus nidulans hyphae.

Duan D, et al. (2012 Nov 23). Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.

Delorme C, et al. (2012 Nov 30). Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein.

Wang B, et al. (2015 Sep). The Aspergillus nidulans bimC4 mutation provides an excellent tool for identification of kinesin-14 inhibitors.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03034
EOG81NS34

sce:absent

Genes: 25

PomBase Description
kinesin-like protein Klp3


AspGD Description
Ortholog(s) have ATP-dependent microtubule motor activity, plus-end-directed, protein dimerization activity, tubulin binding activity


References

Brazer SC, et al. (2000 Jan 30). A fission yeast kinesin affects Golgi membrane recycling.

Browning H, et al. (2000 Oct 2). Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.

Jeong JW, et al. (2002 Jun 30). Cloning and characterization of the kinesin-related protein, Krp1p, in Schizosaccharomyces pombe.

Rhee DK, et al. (2005 Jun 3). ATP-binding motifs play key roles in Krp1p, kinesin-related protein 1, function for bi-polar growth control in fission yeast.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Fu C, et al. (2009 Aug). Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03035
EOG81NS34

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted ATP binding, microtubule binding, microtubule motor activity, role in microtubule-based movement and microtubule associated complex localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03036
EOG81NS34

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted ATP binding, DNA binding, microtubule binding, microtubule motor activity, role in DNA repair, microtubule-based movement and microtubule associated complex localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03037
EOG81NS34

sce:SMY1

Genes: 3

SGD Description
Kinesin-like myosin passenger-protein; interacts with Myo2p; controls actin cable structure and dynamics; proposed to be involved in exocytosis


References

Beltrán C, et al. (1992 Jan 15). Cloning and mutational analysis of the gene encoding subunit C of yeast vacuolar H(+)-ATPase.

Lillie SH, et al. (1992 Mar 26). Suppression of a myosin defect by a kinesin-related gene.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG03038
EOG81NS34

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%