FOG02973
EOG8866VM
sce:FUS3;KSS1
Genes: 44
EOG8866VM
sce:FUS3;KSS1
Genes: 44
SGD Description
Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis|Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
PomBase Description
MAP kinase Spk1
AspGD Description
Ortholog(s) have MAP kinase activity involved in conjugation with cellular fusion activity
References
Courchesne WE, et al. (1989 Sep 22). A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae.
Elion EA, et al. (1990 Feb 23). FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation.
Toda T, et al. (1991 Jan). Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.
Gartner A, et al. (1992 Jul). Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.
Fujimura HA, et al. (1992 Nov). The DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway in Saccharomyces cerevisiae.
Whiteway M, et al. (1992 Oct 15). Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.
Neiman AM, et al. (1993 Jan). Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.
Gotoh Y, et al. (1993 Oct). Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase.
Aono T, et al. (1994 Jun). Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.
Kjaerulff S, et al. (1994 Jun). Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Yabana N, et al. (1996 Jul). Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.
Hakuno F, et al. (1996 Mar). The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.
Cook JG, et al. (1996 Nov 15). Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.
Tedford K, et al. (1997 Apr 1). Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates.
Zaitsevskaya-Carter T, et al. (1997 Mar 17). Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.
Madhani HD, et al. (1997 Nov 28). MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation.
Bardwell L, et al. (1998 Dec 22). Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
Metzgar D, et al. (1998 Feb). Sequence analysis of a compound coding-region microsatellite in Candida albicans resolves homoplasies and provides a high-resolution tool for genotyping.
Yang P, et al. (1998 Jul 17). Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast.
Bardwell L, et al. (1998 Sep 15). Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
van Drogen F, et al. (2001 Dec). MAP kinase dynamics in response to pheromones in budding yeast.
Henkel J, et al. (2001 Jun). Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase Byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe.
Sabbagh W Jr, et al. (2001 Sep). Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation.
Tanabe K, et al. (2003 Dec). Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.
Nelson C, et al. (2003 Jan 9). Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.
Zeitlinger J, et al. (2003 May 2). Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.
Kjaerulff S, et al. (2005 Mar). Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.
Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.
Mata J, et al. (2006 Oct 17). Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.
Paoletti M, et al. (2007 Aug 21). Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans.
Atoui A, et al. (2008 Jun). Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.
Fasolo J, et al. (2011 Apr 1). Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.
Jun SC, et al. (2011 Jun). The MpkB MAP kinase plays a role in post-karyogamy processes as well as in hyphal anastomosis during sexual development in Aspergillus nidulans.
Bayram Ö, et al. (2012). The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.
Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.
Ohtsuka H, et al. (2012 Jan). Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Shimanuki M, et al. (2013). Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
Kang JY, et al. (2013 Dec). The MpkB MAP kinase plays a role in autolysis and conidiation of Aspergillus nidulans.
Kovacikova I, et al. (2013 Feb 15). A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.
Gibbons JG, et al. (2013 Jan). The function and evolution of the Aspergillus genome.
Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.
Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Wang W, et al. (2014 Sep). [Ash2, a subunit of histone H3K4 methyltransferase complex, is involved in the sporulation in Schizosaccharomyces pombe].
Yoshimi A, et al. (2015). Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans.
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FOG02974
EOG8866VM
sce:HOG1
Genes: 34
EOG8866VM
sce:HOG1
Genes: 34
SGD Description
Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII in osmotic shock; activates CDC28 by stimulating antisense RNA transcription; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; with Mrc1p defines novel S-phase checkpoint that prevent conflicts between DNA replication and transcription; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress
PomBase Description
MAP kinase Sty1
AspGD Description
Ortholog(s) have role in carbon utilization, cellular hyperosmotic response, cellular response to drug, cellular response to heat and cellular response to oxidative stress, more|Ortholog(s) have role in carbon utilization, cellular hyperosmotic response, cellular response to drug, cellular response to heat and cellular response to oxidative stress, more|Osmotic sensitivity MAP kinase; highly expressed in dormant conidia
References
Brewster JL, et al. (1993 Mar 19). An osmosensing signal transduction pathway in yeast.
Schüller C, et al. (1994 Sep 15). The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.
Hall JP, et al. (1996 Dec). The osmoregulatory pathway represses mating pathway activity in Saccharomyces cerevisiae: isolation of a FUS3 mutant that is insensitive to the repression mechanism.
Norbeck J, et al. (1996 Jun 7). Purification and characterization of two isoenzymes of DL-glycerol-3-phosphatase from Saccharomyces cerevisiae. Identification of the corresponding GPP1 and GPP2 genes and evidence for osmotic regulation of Gpp2p expression by the osmosensing mitogen-activated protein kinase signal transduction pathway.
San José C, et al. (1996 Oct). The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
Jacoby T, et al. (1997 Jul 11). Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1.
Wurgler-Murphy SM, et al. (1997 Mar). Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases.
Reynolds TB, et al. (1998 Nov 16). The high osmolarity glycerol response (HOG) MAP kinase pathway controls localization of a yeast golgi glycosyltransferase.
O'Rourke SM, et al. (1998 Sep 15). The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae.
Reiser V, et al. (1999 Apr). Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae.
Alonso-Monge R, et al. (1999 May). Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans.
Bansal PK, et al. (2000 Jan 15). Isolation and sequence of the HOG1 homologue from Debaryomyces hansenii by complementation of the hog1Delta strain of Saccharomyces cerevisiae.
Bilsland-Marchesan E, et al. (2000 Jun). Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1.
Mattison CP, et al. (2000 May 15). Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast.
Raitt DC, et al. (2000 Sep 1). Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.
Alepuz PM, et al. (2001 Apr). Stress-induced map kinase Hog1 is part of transcription activation complexes.
Toh-e A, et al. (2001 Dec). Defects in glycosylphosphatidylinositol (GPI) anchor synthesis activate Hog1 kinase and confer copper-resistance in Saccharomyces cerevisisae.
Kapteyn JC, et al. (2001 Jan). Low external pH induces HOG1-dependent changes in the organization of the Saccharomyces cerevisiae cell wall.
Warmka J, et al. (2001 Jan). Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1.
Bell M, et al. (2001 Jul 6). Isolation of hyperactive mutants of the MAPK p38/Hog1 that are independent of MAPK kinase activation.
Kinclová O, et al. (2001 Jun 15). The Zygosaccharomyces rouxii strain CBS732 contains only one copy of the HOG1 and the SOD2 genes.
Proft M, et al. (2001 Mar 1). Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.
Winkler A, et al. (2002 Apr). Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress.
Uesono Y, et al. (2002 Apr 19). Transient inhibition of translation initiation by osmotic stress.
Kawasaki L, et al. (2002 Aug). SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans.
Momany M, et al. (2002 Dec). Polarity in filamentous fungi: establishment, maintenance and new axes.
Young C, et al. (2002 Dec). Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation.
Proft M, et al. (2002 Jun). Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.
Han KH, et al. (2002 Mar). Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulans.
Alonso-Monge R, et al. (2003 Apr). The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.
Bell M, et al. (2003 Apr 25). Phosphorylation of Tyr-176 of the yeast MAPK Hog1/p38 is not vital for Hog1 biological activity.
de Nadal E, et al. (2003 Jan). Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase.
Alepuz PM, et al. (2003 May 15). Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.
Lara-Ortíz T, et al. (2003 Nov). Reactive oxygen species generated by microbial NADPH oxidase NoxA regulate sexual development in Aspergillus nidulans.
Chauhan N, et al. (2003 Oct). Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Lawrence CL, et al. (2004 Apr). Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress.
Nevitt T, et al. (2004 Apr 15). Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress.
De Nadal E, et al. (2004 Jan 22). The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.
Haghnazari E, et al. (2004 Jul 2). The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide.
Escoté X, et al. (2004 Oct). Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1.
Smith DA, et al. (2004 Sep). A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans.
Aguilera J, et al. (2005 Apr). The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae.
Arana DM, et al. (2005 Apr). The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.
Navarro-García F, et al. (2005 Aug). The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.
Furukawa K, et al. (2005 Jun). Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress.
Sharma P, et al. (2005 Mar 25). Evidence that C-terminal non-kinase domain of Pbs2p has a role in high osmolarity-induced nuclear localization of Hog1p.
Vasudevan S, et al. (2005 Nov). p38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript.
Kayingo G, et al. (2005 Sep). The MAP kinase Hog1p differentially regulates stress-induced production and accumulation of glycerol and D-arabitol in Candida albicans.
Sharma P, et al. (2005 Sep). Debaryomyces hansenii, a highly osmo-tolerant and halo-tolerant yeast, maintains activated Dhog1p in the cytoplasm during its growth under severe osmotic stress.
Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.
Westfall PJ, et al. (2006 Aug). Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele.
Marques JM, et al. (2006 Aug 25). Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin.
Chasse SA, et al. (2006 Feb). Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Eisman B, et al. (2006 Feb). The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.
Enjalbert B, et al. (2006 Feb). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.
Prick T, et al. (2006 Feb 15). In yeast, loss of Hog1 leads to osmosensitivity of autophagy.
Panadero J, et al. (2006 Feb 24). A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiae.
Proft M, et al. (2006 Jul 21). The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.
Clotet J, et al. (2006 Jun 7). Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity.
Du C, et al. (2006 May). The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus.
Menon V, et al. (2006 Nov). Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants.
Sotelo J, et al. (2006 Oct). Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.
Thorsen M, et al. (2006 Oct). The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.
Hao N, et al. (2007 Apr 17). A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.
Furukawa K, et al. (2007 Jul). Novel reporter gene expression systems for monitoring activation of the Aspergillus nidulans HOG pathway.
Guha N, et al. (2007 Jul). Plc1p is required for SAGA recruitment and derepression of Sko1p-regulated genes.
Hagiwara D, et al. (2007 Mar). Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses.
Hawle P, et al. (2007 Mar). Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).
Kim S, et al. (2007 Mar 20). Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach.
Hagiwara D, et al. (2008 Dec). Functional analysis of C2H2 zinc finger transcription factor CrzA involved in calcium signaling in Aspergillus nidulans.
Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.
Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.
Han KH, et al. (2009 Sep). Molecular Genetics of Emericella nidulans Sexual Development.
Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.
Lara-Rojas F, et al. (2011 Apr). Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.
Jun SC, et al. (2011 Jun). The MpkB MAP kinase plays a role in post-karyogamy processes as well as in hyphal anastomosis during sexual development in Aspergillus nidulans.
Gao L, et al. (2011 Nov). Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans.
Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.
Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Eigentler A, et al. (2012 Jun). The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Garzia A, et al. (2013 Feb). Transcriptional changes in the transition from vegetative cells to asexual development in the model fungus Aspergillus nidulans.
Ma D, et al. (2013 Feb). Current understanding of HOG-MAPK pathway in Aspergillus fumigatus.
Jaimes-Arroyo R, et al. (2015 May). The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans.
Katz ME, et al. (2015 Oct 23). Extreme Diversity in the Regulation of Ndt80-Like Transcription Factors in Fungi.
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FOG02975
EOG8866VM
sce:SSN3
Genes: 34
EOG8866VM
sce:SSN3
Genes: 34
SGD Description
Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
PomBase Description
cyclin-dependent protein Srb mediator subunit kinase Srb10
AspGD Description
Ortholog(s) have RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity
References
Surosky RT, et al. (1994 May). The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose.
Liao SM, et al. (1995 Mar 9). A kinase-cyclin pair in the RNA polymerase II holoenzyme.
Hengartner CJ, et al. (1998 Jul). Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases.
Holstege FC, et al. (1998 Nov 25). Dissecting the regulatory circuitry of a eukaryotic genome.
Hirst M, et al. (1999 May). GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.
Zaman Z, et al. (2001 Feb 27). Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.
Chi Y, et al. (2001 May 1). Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.
Kang JS, et al. (2001 Nov 9). The structural and functional organization of the yeast mediator complex.
Borggrefe T, et al. (2002 Nov 15). A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast.
Nelson C, et al. (2003 Jan 9). Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.
Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.
Núñez L, et al. (2004 Apr 30). The KlSRB10 gene from Kluyveromyces lactis.
Liu Y, et al. (2004 Feb). Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Hallberg M, et al. (2004 Mar 9). Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid.
Green SR, et al. (2004 Sep). Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.
van de Peppel J, et al. (2005 Aug 19). Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.
Ansari AZ, et al. (2005 Feb 15). Transcriptional activating regions target attached substrates to a cyclin-dependent kinase.
Larschan E, et al. (2005 Jan). The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.
Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.
Andrau JC, et al. (2006 Apr 21). Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.
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2 genes with posterior transmembrane prediction > 50% |
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FOG02976
EOG8866VM
sce:CTK1
Genes: 33
EOG8866VM
sce:CTK1
Genes: 33
SGD Description
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
PomBase Description
P-TEFb-associated cyclin-dependent protein kinase Lsk1
AspGD Description
Has domain(s) with predicted ATP binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferring phosphorus-containing groups activity and role in protein phosphorylation
References
Lee JM, et al. (1991 May). CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.
Sterner DE, et al. (1995 Oct). The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex.
Lee JM, et al. (1997 Apr 25). Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I.
Patturajan M, et al. (1999 Sep 24). Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation.
Jona G, et al. (2001 Apr 4). Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo.
Hautbergue G, et al. (2001 Mar 16). Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits.
Skaar DA, et al. (2002 Dec). The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p.
Ostapenko D, et al. (2003 Apr). Budding yeast CTDK-I is required for DNA damage-induced transcription.
Xiao T, et al. (2003 Mar 1). Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast.
Bouchoux C, et al. (2004). CTD kinase I is involved in RNA polymerase I transcription.
Jones JC, et al. (2004 Jun 11). C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats.
Askree SH, et al. (2004 Jun 8). A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length.
Ostapenko D, et al. (2005 May). Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae.
Van Driessche B, et al. (2005 Oct 10). Glucose deprivation mediates interaction between CTDK-I and Snf1 in Saccharomyces cerevisiae.
Grenetier S, et al. (2006). CTD kinase I is required for the integrity of the rDNA tandem array.
Xiao T, et al. (2007 Jan). The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes.
Röther S, et al. (2007 Jun 1). The RNA polymerase II CTD kinase Ctk1 functions in translation elongation.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
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2 genes with posterior transmembrane prediction > 50% |
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FOG02977
EOG8866VM
sce:SLT2
Genes: 33
EOG8866VM
sce:SLT2
Genes: 33
SGD Description
Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, cell cycle progression, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site (PAS); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog, KDX1, that arose from the whole genome duplication
PomBase Description
MAP kinase Pmk1
AspGD Description
Ortholog(s) have MAP kinase activity involved in cell wall organization or biogenesis activity
References
Torres L, et al. (1991 Nov). A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants.
Mazzoni C, et al. (1993 Dec). The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.
Navarro-García F, et al. (1995 Apr). Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity.
Diez-Orejas R, et al. (1997 Feb). Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis.
Watanabe Y, et al. (1997 May). Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway.
Navarro-García F, et al. (1998 Feb). A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicans.
Bussink HJ, et al. (1999 Apr 1). A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulans.
Mizutani O, et al. (2004 Aug). Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae.
Arana DM, et al. (2005 Apr). The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.
Kumamoto CA, et al. (2005 Apr 12). A contact-activated kinase signals Candida albicans invasive growth and biofilm development.
Navarro-García F, et al. (2005 Aug). The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.
Wiederhold NP, et al. (2005 Dec). Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.
Bates S, et al. (2005 Jun 17). Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence.
Molero G, et al. (2005 Sep). The importance of the phagocytes' innate response in resolution of the infection induced by a low virulent Candida albicans mutant.
Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
Mircus G, et al. (2009 Oct). Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant.
LaFayette SL, et al. (2010 Aug 26). PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.
Binder U, et al. (2010 Jan). The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans.
Soulard A, et al. (2010 Oct 1). The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.
Futagami T, et al. (2011 Nov). Putative stress sensors WscA and WscB are involved in hypo-osmotic and acidic pH stress tolerance in Aspergillus nidulans.
Katayama T, et al. (2012). Involvement of protein kinase C in the suppression of apoptosis and in polarity establishment in Aspergillus nidulans under conditions of heat stress.
Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Futagami T, et al. (2012 Mar 1). Putative cell wall integrity sensor proteins in Aspergillus nidulans.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.
Brown NA, et al. (2013 Jun 25). Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production.
Yaegashi J, et al. (2013 Jun 7). Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans.
Colabardini AC, et al. (2014). Protein kinase C overexpression suppresses calcineurin-associated defects in Aspergillus nidulans and is involved in mitochondrial function.
Prieto D, et al. (2014). The HOG pathway is critical for the colonization of the mouse gastrointestinal tract by Candida albicans.
Yoshimi A, et al. (2015). Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans.
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FOG02978
EOG8866VM
sce:PHO85
Genes: 33
EOG8866VM
sce:PHO85
Genes: 33
SGD Description
Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation
PomBase Description
Pho85/PhoA-like cyclin-dependent kinase Pef1
AspGD Description
Ortholog(s) have cyclin-dependent protein serine/threonine kinase activity
References
Uesono Y, et al. (1987 Dec 23). Negative regulators of the PHO system in Saccharomyces cerevisiae: isolation and structural characterization of PHO85.
Toh-e A, et al. (1988 Sep). PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae.
Kaffman A, et al. (1994 Feb 25). Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85.
Espinoza FH, et al. (1994 Nov 25). Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85.
Measday V, et al. (1994 Nov 25). The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast.
Schneider KR, et al. (1994 Oct 7). Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the CDK inhibitor PHO81.
O'Neill EM, et al. (1996 Jan 12). Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex.
Measday V, et al. (1997 Mar). A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase.
Tennyson CN, et al. (1998 Apr). A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae.
Lee J, et al. (1998 Dec 3). Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton.
Bussink HJ, et al. (1998 Jul 15). A cyclin-dependent kinase family member (PHOA) is required to link developmental fate to environmental conditions in Aspergillus nidulans.
Huang D, et al. (1998 Jun). Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10.
Nishizawa M, et al. (1998 Sep). Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation.
Nishizawa M, et al. (1999 Nov). The Pho85 kinase, a member of the yeast cyclin-dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle.
Wilson WA, et al. (1999 Oct). Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p.
Measday V, et al. (2000 Feb). Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast.
Lee M, et al. (2000 Oct). Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81.
Schier N, et al. (2001 Jun). A Pcl-like cyclin of Aspergillus nidulans is transcriptionally activated by developmental regulators and is involved in sporulation.
Wang Z, et al. (2001 Oct 12). The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p.
Carroll AS, et al. (2001 Oct 23). Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response.
Shemer R, et al. (2002 Aug). Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5.
Shi XZ, et al. (2002 Jul). Analysis of phosphorylation of YJL084c, a yeast protein.
Shi XZ, et al. (2002 Mar). [Phosphorylation of YLR190w by PAP1 PHO85 kinase complex].
Tan YS, et al. (2003 Jan 3). Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo.
Friesen H, et al. (2003 Jul). Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation.
Dou X, et al. (2003 Nov). The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans.
Waters NC, et al. (2004 Jul). The yeast Pho80-Pho85 cyclin-CDK complex has multiple substrates.
Keniry ME, et al. (2004 Mar). The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit.
De Souza CP, et al. (2004 Nov 23). Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans.
Wu D, et al. (2004 Sep 3). The Pho80-like cyclin of Aspergillus nidulans regulates development independently of its role in phosphate acquisition.
Wilson WA, et al. (2005 Apr 1). Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p.
Wanke V, et al. (2005 Dec 21). Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.
Iwaki S, et al. (2005 Feb 25). Phosphorylation by Pho85 cyclin-dependent kinase acts as a signal for the down-regulation of the yeast sphingoid long-chain base kinase Lcb4 during the stationary phase.
Sopko R, et al. (2006 Feb 3). Mapping pathways and phenotypes by systematic gene overexpression.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Katz ME, et al. (2015 Oct 23). Extreme Diversity in the Regulation of Ndt80-Like Transcription Factors in Fungi.
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FOG02979
EOG8866VM
sce:CDC28
Genes: 33
EOG8866VM
sce:CDC28
Genes: 33
SGD Description
Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 (CLNs), S and G2/M (CLBs) phase cyclins, which provide substrate specificity; regulates cell cycle and basal transcription, chromosome duplication and segregation, lipid biosynthesis, membrane trafficking, polarized growth, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA
PomBase Description
cyclin-dependent protein kinase Cdk1/Cdc2
AspGD Description
Ortholog(s) have RNA polymerase II core binding, cyclin-dependent protein serine/threonine kinase activity, histone binding, protein serine/threonine phosphatase inhibitor activity
References
Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.
Lörincz AT, et al. (1984 Jan 12-18). Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes.
Osmani AH, et al. (1991). Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation.
O'Connell MJ, et al. (1992 Jun). An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans.
Doonan JH, et al. (1992 Nov). Cell division in Aspergillus.
Sherlock G, et al. (1994 Dec 15). Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans.
Osmani AH, et al. (1994 Jun). A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.
Lu KP, et al. (1995). The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.
Lu KP, et al. (1995 May 5). Evidence for a NIMA-like mitotic pathway in vertebrate cells.
James SW, et al. (1995 Nov). The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.
Fry AM, et al. (1995 Oct 1). Cell cycle. The NIMA kinase joins forces with Cdc2.
Osmani SA, et al. (1996 Aug 1). Cell cycle regulation in Aspergillus by two protein kinases.
Ye XS, et al. (1996 Jul 15). Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.
Damagnez V, et al. (1996 Jun 12). Candida albicans CDK1 and CYB1: cDNA homologues of the cdc2/CDC28 and cdc13/CLB1/CLB2 cell cycle control genes.
Ye XS, et al. (1997). Regulation of p34cdc2/cyclinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans.
Ye XS, et al. (1997 Jan 2). The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.
Krien MJ, et al. (1998 Apr). A NIMA homologue promotes chromatin condensation in fission yeast.
Bussink HJ, et al. (1998 Jul 15). A cyclin-dependent kinase family member (PHOA) is required to link developmental fate to environmental conditions in Aspergillus nidulans.
Wu L, et al. (1998 Jun 29). A role for NIMA in the nuclear localization of cyclin B in Aspergillus nidulans.
Harris SD, et al. (1998 Mar). Regulation of septum formation in Aspergillus nidulans by a DNA damage checkpoint pathway.
Lies CM, et al. (1998 May). BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.
De Souza CP, et al. (1999 Nov). Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans.
McGuire SL, et al. (2000 Dec). Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation.
Joseph JD, et al. (2000 Dec 8). Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.
Harris SD, et al. (2001 Dec). Septum formation in Aspergillus nidulans.
Kraus PR, et al. (2001 Oct). The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints.
Hazan I, et al. (2002 Jan). Hyphal elongation is regulated independently of cell cycle in Candida albicans.
Schier N, et al. (2002 Jul 17). The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimX(Cdc2).
Cheng J, et al. (2003 Jan). Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans.
O'Connell MJ, et al. (2003 May). Never say never. The NIMA-related protein kinases in mitotic control.
Ubersax JA, et al. (2003 Oct 23). Targets of the cyclin-dependent kinase Cdk1.
Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.
Zheng X, et al. (2004 Apr 21). Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.
Joseph JD, et al. (2004 Jul 30). PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.
Lin X, et al. (2004 Nov). Identification and complementation of abnormal hyphal branch mutants ahbA1 and ahbB1 in Aspergillus nidulans.
Umeyama T, et al. (2005 Jan). Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.
Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Momany M, et al. (2005 May). Growth control and polarization.
De Souza CP, et al. (2006 Dec). A point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivity.
Umeyama T, et al. (2006 May). Repression of CDC28 reduces the expression of the morphology-related transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and induces cell elongation in Candida albicans.
Zheng XD, et al. (2007 Aug 22). Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth.
Uppuluri P, et al. (2007 Jun). Defining Candida albicans stationary phase by cellular and DNA replication, gene expression and regulation.
Sinha I, et al. (2007 Sep). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.
Li CR, et al. (2008 Nov 19). The IQGAP Iqg1 is a regulatory target of CDK for cytokinesis in Candida albicans.
Wang A, et al. (2009 Aug). Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Wu XZ, et al. (2010 Apr). Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway.
Seiler S, et al. (2010 Dec). Conserved components, but distinct mechanisms for the placement and assembly of the cell division machinery in unicellular and filamentous ascomycetes.
Bishop A, et al. (2010 Sep 1). Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase.
Gutiérrez-Escribano P, et al. (2011 Jul 15). CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.
Senn H, et al. (2012 Jan). Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Li CR, et al. (2012 May 15). CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4.
Zeng G, et al. (2012 Sep). Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Kang EH, et al. (2013). LAMMER Kinase LkhA plays multiple roles in the vegetative growth and asexual and sexual development of Aspergillus nidulans.
Wang H, et al. (2013 Feb 1). Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans.
De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.
James SW, et al. (2014 Oct). Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans.
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FOG02980
EOG8866VM
sce:KIN28
Genes: 33
EOG8866VM
sce:KIN28
Genes: 33
SGD Description
Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia
PomBase Description
TFIIH associated cyclin-dependent protein kinase Mcs6
AspGD Description
Ortholog(s) have RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein serine/threonine kinase activity
References
Simon M, et al. (1986 Oct). KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.
Molz L, et al. (1989 Aug). cdc2 and the regulation of mitosis: six interacting mcs genes.
Warbrick E, et al. (1992 Apr). Five novel elements involved in the regulation of mitosis in fission yeast.
Valay JG, et al. (1993 Nov 20). The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae.
Buck V, et al. (1995 Dec 15). Identification of a cdk-activating kinase in fission yeast.
Damagnez V, et al. (1995 Dec 15). Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.
Feaver WJ, et al. (1997 Aug 1). Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits.
Umeda M, et al. (1998 Apr 28). A distinct cyclin-dependent kinase-activating kinase of Arabidopsis thaliana.
Hermand D, et al. (1998 Dec 15). Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Espinoza FH, et al. (1998 Nov). Cak1 is required for Kin28 phosphorylation and activation in vivo.
Lee KM, et al. (1999 Apr 22). Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs).
Kimmelman J, et al. (1999 Jul). Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p.
Rodriguez CR, et al. (2000 Jan). Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.
Spåhr H, et al. (2000 Jan 14). Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.
Korsisaari N, et al. (2000 Nov 10). Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.
Hermand D, et al. (2001 Jan 15). Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast.
Saiz JE, et al. (2002 Jul 9). A CDK-activating kinase network is required in cell cycle control and transcription in fission yeast.
Keogh MC, et al. (2002 Mar). Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation.
Spahr H, et al. (2003 Dec 19). Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.
Alepuz PM, et al. (2003 May 15). Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.
Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.
Bamps S, et al. (2004 Dec 24). Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission yeast.
Shimotohno A, et al. (2004 Nov). The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis.
Lee KM, et al. (2005 Jun). Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.
Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Gerber HB, et al. (2008 Jan 30). The CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Lemieux C, et al. (2009 Jun). Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Viladevall L, et al. (2009 Mar 27). TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.
Coudreuse D, et al. (2010 Jun 22). A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.
Sansó M, et al. (2012). A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.
St Amour CV, et al. (2012 Jul). Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Devos M, et al. (2015 May). Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Mbogning J, et al. (2015 Nov 16). Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.
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1 genes with posterior transmembrane prediction > 50% |
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FOG02981
EOG8866VM
sce:SGV1
Genes: 32
EOG8866VM
sce:SGV1
Genes: 32
SGD Description
Cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal domain (CTD) of Rpo21p and the C-terminal repeat domain of Spt5p; recruits Spt6p to the CTD at the onset of transcription; regulated by Cak1p; similar to metazoan CDK9 proteins
PomBase Description
P-TEFb-associated cyclin-dependent protein kinase Cdk9
AspGD Description
Ortholog(s) have ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein serine/threonine kinase activity
References
Irie K, et al. (1991 May 31). SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae.
Prelich G, et al. (1993 Nov). Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo.
Yao S, et al. (2000 Oct). BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo.
Murray S, et al. (2001 Jul). Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase.
Yao S, et al. (2002 Oct). Activation of the Bur1-Bur2 cyclin-dependent kinase complex by Cak1.
Keogh MC, et al. (2003 Oct). Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.
Laribee RN, et al. (2005 Aug 23). BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex.
Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Wood A, et al. (2005 Nov 23). The Bur1/Bur2 complex is required for histone H2B monoubiquitination by Rad6/Bre1 and histone methylation by COMPASS.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Bathe F, et al. (2010 Dec). Functional characterization of a new member of the Cdk9 family in Aspergillus nidulans.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Kempf C, et al. (2013 Jan). Evidence that two Pcl-like cyclins control Cdk9 activity during cell differentiation in Aspergillus nidulans asexual development.
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0 genes with posterior transmembrane prediction > 50% |
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FOG02982
EOG8866VM
sce:absent
Genes: 8
EOG8866VM
sce:absent
Genes: 8
PomBase Description
serine/threonine protein kinase cdk11
AspGD Description
Ortholog(s) have role in intra-S DNA damage checkpoint and nucleus localization
References
Fagundes MR, et al. (2004 Aug). The Aspergillus nidulans npkA gene encodes a Cdc2-related kinase that genetically interacts with the UvsBATR kinase.
Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.
Fagundes MR, et al. (2005 Jul). Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damage.
Lima JF, et al. (2005 Nov). The csnD/csnE signalosome genes are involved in the Aspergillus nidulans DNA damage response.
Malavazi I, et al. (2008 Feb). Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.
Drogat J, et al. (2012 Nov 29). Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02983
EOG8866VM
sce:absent
Genes: 5
EOG8866VM
sce:absent
Genes: 5
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02984
EOG8866VM
sce:KDX1
Genes: 3
EOG8866VM
sce:KDX1
Genes: 3
SGD Description
Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication
AspGD Description
Has domain(s) with predicted ATP binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferring phosphorus-containing groups activity and role in protein phosphorylation|Has domain(s) with predicted ATP binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferring phosphorus-containing groups activity and role in protein phosphorylation
References
Watanabe Y, et al. (1997 May). Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway.
Zhu H, et al. (2000 Nov). Analysis of yeast protein kinases using protein chips.
Rodriguez-Peña JM, et al. (2008 Feb 1). A yeast strain biosensor to detect cell wall-perturbing agents.
Breitkreutz A, et al. (2010 May 21). A global protein kinase and phosphatase interaction network in yeast.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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