FOG02959
EOG88SF7W
sce:BAG7;SAC7
Genes: 39
EOG88SF7W
sce:BAG7;SAC7
Genes: 39
SGD Description
Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication|GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication
PomBase Description
Rho-type GTPase activating protein Rga5
AspGD Description
Rho-GTPase activating protein (Rho-GAP); induced by caspofungin
References
Dunn TM, et al. (1990 May). Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae.
Schmidt A, et al. (1997 Feb 21). The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.
Roumanie O, et al. (2001 Oct 5). Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02960
EOG88SF7W
sce:RGD1
Genes: 34
EOG88SF7W
sce:RGD1
Genes: 34
SGD Description
GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization
PomBase Description
Rho-type GTPase activating protein Rga7
AspGD Description
Ortholog(s) have GTPase activator activity
References
Barthe C, et al. (1998 Jun). First characterization of the gene RGD1 in the yeast Saccharomyces cerevisiae.
de Bettignies G, et al. (1999 Dec). RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae.
Doignon F, et al. (1999 Oct 15). The yeast Rgd1p is a GTPase activating protein of the Rho3 and rho4 proteins.
de Bettignies G, et al. (2001 Dec). Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae.
Claret S, et al. (2005 Aug). The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae.
Gatti X, et al. (2005 May 23). RGD1, encoding a RhoGAP involved in low-pH survival, is an Msn2p/Msn4p regulated gene in Saccharomyces cerevisiae.
Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Vieillemard A, et al. (2013 Mar 29). The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.
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0 genes with posterior transmembrane prediction > 50% |
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FOG02961
EOG88SF7W
sce:LRG1
Genes: 33
EOG88SF7W
sce:LRG1
Genes: 33
SGD Description
GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains
PomBase Description
Rho-type GTPase activating protein Rga1
AspGD Description
Ortholog(s) have GTPase activator activity
References
Müller L, et al. (1994 Aug 11). LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains.
Watanabe D, et al. (2001 Jul). Yeast Lrg1p acts as a specialized RhoGAP regulating 1,3-beta-glucan synthesis.
Roumanie O, et al. (2001 Oct 5). Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
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| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
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FOG02962
EOG88SF7W
sce:BEM3
Genes: 29
EOG88SF7W
sce:BEM3
Genes: 29
SGD Description
Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
PomBase Description
Rho-type GTPase activating protein Rga2
AspGD Description
Ortholog(s) have GTPase activator activity, role in negative regulation of Rho protein signal transduction, positive regulation of GTPase activity and actomyosin contractile ring, growing cell tip localization
References
Zheng Y, et al. (1993 Nov 25). Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain.
Zheng Y, et al. (1994 Jan 28). Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
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| Phobius transmembrane predictions
9 genes with posterior transmembrane prediction > 50% |
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FOG02963
EOG88SF7W
sce:PXL1
Genes: 26
EOG88SF7W
sce:PXL1
Genes: 26
SGD Description
Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
AspGD Description
Has domain(s) with predicted zinc ion binding activity
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02964
EOG88SF7W
sce:BEM2
Genes: 26
EOG88SF7W
sce:BEM2
Genes: 26
SGD Description
Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p
References
Chan CS, et al. (1993 Nov). Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.
Kim YJ, et al. (1994 Dec). Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation.
Peterson J, et al. (1994 Dec). Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.
Wendland J, et al. (2000 May). Determination of cell polarity in germinated spores and hyphal tips of the filamentous ascomycete Ashbya gossypii requires a rhoGAP homolog.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
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| Phobius transmembrane predictions
16 genes with posterior transmembrane prediction > 50% |
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FOG02965
EOG88SF7W
sce:RGA1;RGA2
Genes: 24
EOG88SF7W
sce:RGA1;RGA2
Genes: 24
SGD Description
GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication|GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication
References
Ramer SW, et al. (1992 Dec 1). Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.
Stevenson BJ, et al. (1995 Dec 1). Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.
Chen GC, et al. (1996 Apr). The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02966
EOG88SF7W
EOG89S4Q0
sce:ECM25
Genes: 21
EOG88SF7W
EOG89S4Q0
sce:ECM25
Genes: 21
SGD Description
Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
References
Arenas JE, et al. (1993 Jul 15). The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome.
Lussier M, et al. (1997 Oct). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.
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| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
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FOG02967
EOG88SF7W
sce:absent
Genes: 11
EOG88SF7W
sce:absent
Genes: 11
PomBase Description
Rho-type GTPase activating protein Rga4
AspGD Description
Ortholog(s) have GTPase activator activity
References
Nakano K, et al. (2001 Dec). Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe.
Das M, et al. (2007 Jun). Regulation of cell diameter, For3p localization, and cell symmetry by fission yeast Rho-GAP Rga4p.
Tatebe H, et al. (2008 Mar 11). Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast.
Das M, et al. (2009 Aug 11). The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Soto T, et al. (2010 Apr 9). Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.
Dodgson J, et al. (2010 Nov). Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.
Cansado J, et al. (2010 Sep). Rga4, a Rho-GAP from fission yeast: Finding specificity within promiscuity.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Kelly FD, et al. (2011 Oct). Spatial control of Cdc42 activation determines cell width in fission yeast.
Vjestica A, et al. (2013). Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.
Deng L, et al. (2013 Jun). Compartmentalized nodes control mitotic entry signaling in fission yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Kokkoris K, et al. (2014 May 1). The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
Das M, et al. (2015 Oct 1). Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.
Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Revilla-Guarinos MT, et al. (2016 Mar 9). Rga6 is a Fission Yeast Rho GAP Involved in Cdc42 Regulation of Polarized Growth.
Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
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0 genes with posterior transmembrane prediction > 50% |
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FOG02968
EOG89S4Q0
sce:absent
Genes: 8
EOG89S4Q0
sce:absent
Genes: 8
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02969
EOG88SF7W
sce:absent
Genes: 4
EOG88SF7W
sce:absent
Genes: 4
AspGD Description
Has domain(s) with predicted role in signal transduction and intracellular localization
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG02970
EOG88SF7W
sce:absent
Genes: 4
EOG88SF7W
sce:absent
Genes: 4
AspGD Description
Has domain(s) with predicted zinc ion binding activity
References
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02971
EOG88SF7W
sce:absent
Genes: 3
EOG88SF7W
sce:absent
Genes: 3
PomBase Description
paxillin-like protein Pxl1
References
Ge W, et al. (2008 Apr). Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast.
Pinar M, et al. (2008 Apr). Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.
Roberts-Galbraith RH, et al. (2009 Jan 12). The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.
Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Martín-García R, et al. (2014 Oct 1). F-BAR domain protein Rga7 collaborates with Cdc15 and Imp2 to ensure proper cytokinesis in fission yeast.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
McDonald NA, et al. (2015 Dec 21). Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.
Ren L, et al. (2015 Jan 15). The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.
Cortés JC, et al. (2015 Jul). Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast.
Liu Y, et al. (2016 Aug 15). Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.
Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Sethi K, et al. (2016 Oct). A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Snider CE, et al. (2017 Oct 2). Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis.
McDonald NA, et al. (2017 Sep 15). Nanoscale architecture of the <i>Schizosaccharomyces pombe</i> contractile ring.
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0 genes with posterior transmembrane prediction > 50% |
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FOG02972
EOG88SF7W
sce:absent
Genes: 6
EOG88SF7W
sce:absent
Genes: 6
PomBase Description
Rho-type GTPase activating protein (predicted)|Rho-type GTPase activating protein Rga3|Rho-type GTPase activating protein Rga6 (predicted)
References
Ding DQ, et al. (2000 Mar). Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Nakano K, et al. (2001 Dec). Characterization of GTPase-activating proteins for the function of the Rho-family small GTPases in the fission yeast Schizosaccharomyces pombe.
Decottignies A, et al. (2003 Mar). Schizosaccharomyces pombe essential genes: a pilot study.
Gregan J, et al. (2005 Sep 20). Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Rumpf C, et al. (2010 May). High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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