FOG02943
EOG8BZKHP

sce:FRK1;KIN4

Genes: 37

SGD Description
Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication|Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication


PomBase Description
serine/threonine protein kinase Ppk1 (predicted)


AspGD Description
Ortholog(s) have role in ascospore formation, cell septum assembly, conidium formation, hyphal growth, response to fungicide, response to salt stress, sporocarp development involved in sexual reproduction


References

Kambouris NG, et al. (1993 Feb). Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae.

Breitkreutz A, et al. (2010 May 21). A global protein kinase and phosphatase interaction network in yeast.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Tarhan C, et al. (2012 Oct 25). Does copper stress lead to spindle misposition-dependent cell cycle arrest?

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 17 genes with posterior transmembrane prediction > 50%

FOG02944
EOG8BZKHP

sce:CMK2;CMK1

Genes: 36

SGD Description
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication|Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication


AspGD Description
Ca2+/calmodulin-dependent protein kinase


References

Bartelt DC, et al. (1988 May). Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans.

Ohya Y, et al. (1991 Jul 5). Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2.

Pausch MH, et al. (1991 Jun). Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote.

Kornstein LB, et al. (1992 Apr 1). Cloning and sequence determination of a cDNA encoding Aspergillus nidulans calmodulin-dependent multifunctional protein kinase.

Dayton JS, et al. (1996 Oct). Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.

Dayton JS, et al. (1997 Feb 7). Expression of a constitutively active Ca2+/calmodulin-dependent kinase in Aspergillus nidulans spores prevents germination and entry into the cell cycle.

Joseph JD, et al. (2002 Feb). Calcium binding is required for calmodulin function in Aspergillus nidulans.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02945
EOG8BZKHP

sce:MYO3;MYO5

Genes: 35

SGD Description
One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication|One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication


PomBase Description
myosin type I


AspGD Description
Ortholog(s) have microfilament motor activity


References

Goodson HV, et al. (1995). Identification and molecular characterization of a yeast myosin I.

McGoldrick CA, et al. (1995 Feb). myoA of Aspergillus nidulans encodes an essential myosin I required for secretion and polarized growth.

Geli MI, et al. (1996 Apr 26). Role of type I myosins in receptor-mediated endocytosis in yeast.

Goodson HV, et al. (1996 Jun). Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.

Wu C, et al. (1997 Dec 5). The phosphorylation site for Ste20p-like protein kinases is essential for the function of myosin-I in yeast.

Anderson BL, et al. (1998 Jun 15). The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization.

Yamashita RA, et al. (1998 Jun 5). Constitutive activation of endocytosis by mutation of myoA, the myosin I gene of Aspergillus nidulans.

Osherov N, et al. (1998 Oct 9). Structural requirements for in vivo myosin I function in Aspergillus nidulans.

Geli MI, et al. (2000 Aug 15). An intact SH3 domain is required for myosin I-induced actin polymerization.

Yamashita RA, et al. (2000 Feb). Localization of wild type and mutant class I myosin proteins in Aspergillus nidulans using GFP-fusion proteins.

Suelmann R, et al. (2000 Jan). Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans.

Evangelista M, et al. (2000 Jan 24). A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.

Lechler T, et al. (2000 Jan 24). Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.

Suelmann R, et al. (2000 May). Nuclear migration in fungi--different motors at work.

Lee WL, et al. (2000 Nov 13). Fission yeast myosin-I, Myo1p, stimulates actin assembly by Arp2/3 complex and shares functions with WASp.

Liu X, et al. (2001 Jul 31). Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s).

Toya M, et al. (2001 Mar). Identification and functional analysis of the gene for type I myosin in fission yeast.

Oberholzer U, et al. (2002 Apr). Myosin I is required for hypha formation in Candida albicans.

Mochida J, et al. (2002 Mar). The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae.

Soulard A, et al. (2002 Nov). Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.

Pelham RJ, et al. (2002 Sep 5). Actin dynamics in the contractile ring during cytokinesis in fission yeast.

Wesche S, et al. (2003 Apr 29). The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.

Toi H, et al. (2003 Jun). She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae.

Carnahan RH, et al. (2003 Sep 1). The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe.

Oberholzer U, et al. (2004 Oct). Functional characterization of myosin I tail regions in Candida albicans.

Lord M, et al. (2004 Oct 25). UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.

Sirotkin V, et al. (2005 Aug 15). Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast.

Takeda T, et al. (2005 Jul 26). Role of fission yeast myosin I in organization of sterol-rich membrane domains.

Itadani A, et al. (2006). Localization of type I myosin and F-actin to the leading edge region of the forespore membrane in Schizosaccharomyces pombe.

Musi V, et al. (2006 Apr). New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae.

Grosshans BL, et al. (2006 Apr 21). TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.

Barker SL, et al. (2007 Aug). Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Horio T, et al. (2007 Jan). Role of microtubules in tip growth of fungi.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Codlin S, et al. (2008 Jun). btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Calvo IA, et al. (2009 Aug 12). Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Amorim MJ, et al. (2009 Feb). Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Attanapola SL, et al. (2009 Nov 1). Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.

Sirotkin V, et al. (2010 Aug 15). Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Clayton JE, et al. (2010 Aug 24). Differential regulation of unconventional fission yeast myosins via the actin track.

Mata J, et al. (2010 Feb). Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.

Roberts-Galbraith RH, et al. (2010 Jul 9). Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Ma Y, et al. (2011). Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Basu R, et al. (2011 Jun 7). Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis.

Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Arasada R, et al. (2011 Sep 13). Distinct roles for F-BAR proteins Cdc15p and Bzz1p in actin polymerization at sites of endocytosis in fission yeast.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Scheffler K, et al. (2014 Dec 16). Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Encinar del Dedo J, et al. (2014 Oct). Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2015 Mar 30). A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Petrini E, et al. (2015 Oct 15). A new phosphate-starvation response in fission yeast requires the endocytic function of myosin I.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Makushok T, et al. (2016 May 19). Sterol-Rich Membrane Domains Define Fission Yeast Cell Polarity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02946
EOG8BZKHP

sce:KIN1;KIN2

Genes: 35

SGD Description
Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication


PomBase Description
microtubule affinity-regulating kinase Kin1


AspGD Description
Ortholog(s) have role in ascospore formation, cell growth mode switching, monopolar to bipolar, conidiophore development, conidium formation and establishment or maintenance of actin cytoskeleton polarity, more


References

Levin DE, et al. (1987 Sep). Two yeast genes that encode unusual protein kinases.

Lamb A, et al. (1991 Apr). The product of the KIN1 locus in Saccharomyces cerevisiae is a serine/threonine-specific protein kinase.

Donovan M, et al. (1994 Jan). Characterization of the KIN2 gene product in Saccharomyces cerevisiae and comparison between the kinase activities of p145KIN1 and p145KIN2.

Tibbetts M, et al. (1994 Jul). KIN1 and KIN2 protein kinases localize to the cytoplasmic face of the yeast plasma membrane.

Elbert M, et al. (2005 Feb). The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02947
EOG8BZKHP

sce:SNF1

Genes: 34

SGD Description
AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ubiquitin ligase


PomBase Description
AMP-activated protein serine/threonine kinase alpha subunit Ssp2


AspGD Description
Ortholog(s) have AMP-activated protein kinase activity, ARF guanyl-nucleotide exchange factor activity


References

Celenza JL, et al. (1984 Jan). Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae.

Celenza JL, et al. (1984 Jan). Structure and expression of the SNF1 gene of Saccharomyces cerevisiae.

Celenza JL, et al. (1986 Sep 12). A yeast gene that is essential for release from glucose repression encodes a protein kinase.

Bisson LF, et al. (1988 Oct). High-affinity glucose transport in Saccharomyces cerevisiae is under general glucose repression control.

Celenza JL, et al. (1989 Nov). Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase.

Celenza JL, et al. (1989 Nov). Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein.

Swanson MS, et al. (1990 Sep). SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.

Denis CL, et al. (1991 Oct). The CCR1 (SNF1) and SCH9 protein kinases act independently of cAMP-dependent protein kinase and the transcriptional activator ADR1 in controlling yeast ADH2 expression.

Estruch F, et al. (1992 Nov). N-terminal mutations modulate yeast SNF1 protein kinase function.

Yang X, et al. (1994 Dec 15). A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.

Ulery TL, et al. (1994 Feb). Glucose repression of yeast mitochondrial transcription: kinetics of derepression and role of nuclear genes.

Mitchelhill KI, et al. (1994 Jan 28). Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

Petter R, et al. (1996 Dec). Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata.

Lesage P, et al. (1996 May). Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response.

Jiang R, et al. (1997 Apr). The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex.

Willins DA, et al. (1997 Jun). Mutations in the heavy chain of cytoplasmic dynein suppress the nudF nuclear migration mutation of Aspergillus nidulans.

McCartney RR, et al. (2001 Sep 28). Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit.

Nath N, et al. (2003 Jun). Yeast Pak1 kinase associates with and activates Snf1.

Charbon G, et al. (2004 May). Key role of Ser562/661 in Snf1-dependent regulation of Cat8p in Saccharomyces cerevisiae and Kluyveromyces lactis.

Rudolph MJ, et al. (2005 Dec 2). Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1.

Lo WS, et al. (2005 Mar 9). Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms.

Van Driessche B, et al. (2005 Oct 10). Glucose deprivation mediates interaction between CTDK-I and Snf1 in Saccharomyces cerevisiae.

Nayak V, et al. (2006 Mar). Structure and dimerization of the kinase domain from yeast Snf1, a member of the Snf1/AMPK protein family.

Elbing K, et al. (2006 Sep 8). Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity.

Sarma NJ, et al. (2007 Mar). Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism.

Amodeo GA, et al. (2007 Sep 27). Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1.

Chen L, et al. (2009 Jun 25). Structural insight into the autoinhibition mechanism of AMP-activated protein kinase.

Rudolph MJ, et al. (2010 Sep 1). An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mayer FV, et al. (2011 Nov 2). ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Brown NA, et al. (2013 Jun 25). Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production.

Simpson-Lavy KJ, et al. (2013 Oct 22). SUMOylation regulates the SNF1 protein kinase.

Krohn NG, et al. (2014 Jan 10). The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.

Ramsubramaniam N, et al. (2014 Nov). The phosphoproteome of Aspergillus nidulans reveals functional association with cellular processes involved in morphology and secretion.

Mizuno T, et al. (2015). The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response.

de Assis LJ, et al. (2015). Aspergillus nidulans protein kinase A plays an important role in cellulase production.

Braun KA, et al. (2015 Dec 14). Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product.

DeMille D, et al. (2015 Feb 1). PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1.

Jiao R, et al. (2015 Jun 19). The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span.

Ferrer-Dalmau J, et al. (2015 May 15). Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.

Nicastro R, et al. (2015 Oct 9). Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02948
EOG8R4XKF

sce:SAT4

Genes: 33

SGD Description
Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion


PomBase Description
serine/threonine protein kinase Hal4


AspGD Description
Ortholog(s) have role in cellular calcium ion homeostasis, cellular response to cation stress and cytosol localization


References

Skala J, et al. (1991 Aug-Sep). The open reading frame YCR101 located on chromosome III from Saccharomyces cerevisiae is a putative protein kinase.

Mulet JM, et al. (1999 May). A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter.

Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.

Wang LY, et al. (2005 May). Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Espeso EA, et al. (2005 Oct). Discrepancies between recombination frequencies and physical distances in Aspergillus nidulans: implications for gene identification.

Thornton G, et al. (2005 Oct). A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Findon H, et al. (2010 Jul). Analysis of a novel calcium auxotrophy in Aspergillus nidulans.

Tanae K, et al. (2012). Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Alao JP, et al. (2015). Suppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mellado L, et al. (2015 Sep). A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02949
EOG8BZKHP

sce:IPL1

Genes: 32

SGD Description
Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest


PomBase Description
aurora-B kinase Ark1


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity


References

Francisco L, et al. (1994 Jul). Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

Kim JH, et al. (1999 Jun 28). Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae.

Hsu JY, et al. (2000 Aug 4). Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.

Kang J, et al. (2001 Nov 26). Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation.

Tanaka TU, et al. (2002 Feb 8). Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

Cheeseman IM, et al. (2002 Oct 18). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Vieillemard A, et al. (2013 Mar 29). The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02950
EOG86T1HN
EOG8BZKHP
EOG8R4XKF

sce:HSL1

Genes: 32

SGD Description
Nim1p-related protein kinase; regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p


PomBase Description
NIM1 family serine/threonine protein kinase Cdr1/Nim1|serine/threonine protein kinase Cdr2


References

Ma XJ, et al. (1996 Jun 1). A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae.

Wightman R, et al. (2004 Feb 16). In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization.

Umeyama T, et al. (2005 Jan). Candida albicans protein kinase CaHsl1p regulates cell elongation and virulence.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02951
EOG8BZKHP

sce:CDC5

Genes: 31

SGD Description
Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate


PomBase Description
Polo kinase Plo1


References

Kitada K, et al. (1993 Jul). A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

Alexandru G, et al. (2001 May 18). Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast.

Stegmeier F, et al. (2002 Jan 25). Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase.

Yoshida S, et al. (2002 Jun 14). Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02952
EOG8R4XKF

sce:CHK1

Genes: 27

SGD Description
Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase


PomBase Description
Chk1 protein kinase


AspGD Description
Ortholog(s) have protein serine/threonine kinase activity


References

Sanchez Y, et al. (1999 Nov 5). Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Malavazi I, et al. (2008 Feb). Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG02953
EOG8BZKHP

sce:DUN1

Genes: 26

SGD Description
Cell-cycle checkpoint serine-threonine kinase; required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; Mec1p and Dun1p function in same pathway to regulate both dNTP pools and telomere length; also regulates postreplicative DNA repair


AspGD Description
Putative serine/threonine-protein kinase; induced by caspofungin


References

Zhou Z, et al. (1993 Dec 17). DUN1 encodes a protein kinase that controls the DNA damage response in yeast.

Hammet A, et al. (2002 Jun 21). Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.

Zhao X, et al. (2002 Mar 19). The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Malavazi I, et al. (2008 Feb). Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%

FOG02954
EOG8BZKHP
EOG8XWDDG

sce:TDA1

Genes: 24

SGD Description
Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress


PomBase Description
calcium/calmodulin-dependent protein kinase Cmk1


AspGD Description
Ca2+/calmodulin-dependent protein kinase


References

Joseph JD, et al. (2000 Dec 8). Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans.

Rasmussen CD, et al. (2000 Jan 7). Cloning of a calmodulin kinase I homologue from Schizosaccharomyces pombe.

Zhu H, et al. (2000 Nov). Analysis of yeast protein kinases using protein chips.

Joseph JD, et al. (2002 Feb). Calcium binding is required for calmodulin function in Aspergillus nidulans.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Koyano T, et al. (2010). Search for kinases related to transition of growth polarity in fission yeast.

Fasolo J, et al. (2011 Apr 1). Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Reid RJ, et al. (2011 Mar). Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage.

Tanae K, et al. (2012). Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Cisneros-Barroso E, et al. (2014 Sep). Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%

FOG02955
EOG8BZKHP

sce:GIN4;KCC4

Genes: 23

SGD Description
Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication|Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication


References

Longtine MS, et al. (1998 Nov 2). Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function.

Barral Y, et al. (1999 Jan 15). Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast.

Okuzaki D, et al. (2001 Feb 2). Kcc4 associates with septin proteins of Saccharomyces cerevisiae.

Mortensen EM, et al. (2002 Jun). Cell cycle-dependent assembly of a Gin4-septin complex.

Okuzaki D, et al. (2003 Apr). The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions.

Wightman R, et al. (2004 Feb 16). In Candida albicans, the Nim1 kinases Gin4 and Hsl1 negatively regulate pseudohypha formation and Gin4 also controls septin organization.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Li CR, et al. (2007 Jun 1). Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation.

Sinha I, et al. (2007 Sep). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.

Calvert ME, et al. (2008 Feb). Phosphorylation by casein kinase 2 regulates Nap1 localization and function.

Li CR, et al. (2012 May 15). CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02956
EOG8R4XKF

sce:absent

Genes: 13

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02957
EOG8BZKHP

sce:absent

Genes: 3

AspGD Description
Ortholog(s) have role in G2/M transition of mitotic cell cycle and asexual sporulation resulting in formation of a cellular spore, more


References

De Souza CP, et al. (2004 Nov 23). Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans.

Bachewich C, et al. (2005 Jan). The polo-like kinase PLKA is required for initiation and progression through mitosis in the filamentous fungus Aspergillus nidulans.

Petersen J, et al. (2005 May 26). Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast.

Seiler S, et al. (2010 Dec). Conserved components, but distinct mechanisms for the placement and assembly of the cell division machinery in unicellular and filamentous ascomycetes.

Mogilevsky K, et al. (2012 Feb). The Polo-like kinase PLKA in Aspergillus nidulans is not essential but plays important roles during vegetative growth and development.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02958
EOG8BZKHP

sce:absent

Genes: 4

PomBase Description
serine/threonine protein kinase Ppk25 (predicted)


AspGD Description
Has domain(s) with predicted ATP binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferring phosphorus-containing groups activity and role in protein phosphorylation|Protein of unknown function


References

Drewes G, et al. (2003 Nov 6). The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth.

Bimbó A, et al. (2005 Apr). Systematic deletion analysis of fission yeast protein kinases.

Gupta S, et al. (2013 Feb 18). Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%