FOG02900
EOG8N2Z4N

sce:SIS1

Genes: 34

SGD Description
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1


PomBase Description
DNAJ domain protein, involved in translation initiation Psi1


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Luke MM, et al. (1991 Aug). Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.

Zhong T, et al. (1993 Jun 18). The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation.

Horton LE, et al. (2001 Apr 27). The yeast hsp70 homologue Ssa is required for translation and interacts with Sis1 and Pab1 on translating ribosomes.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Vjestica A, et al. (2013). Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02901
EOG8N2Z4N

sce:absent

Genes: 7

PomBase Description
DNAJ domain protein


AspGD Description
Ortholog(s) have endoplasmic reticulum localization


References

Matia-González AM, et al. (2013 Jun). Functional characterization of Upf1 targets in Schizosaccharomyces pombe.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG02902
EOG8N2Z4N

sce:YDJ1

Genes: 33

SGD Description
Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitylation after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family


PomBase Description
DNAJ domain protein Mas5 (predicted)


AspGD Description
Ortholog(s) have ATPase activator activity, unfolded protein binding activity


References

Caplan AJ, et al. (1991 Aug). Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein.

Atencio DP, et al. (1992 Jan). MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import.

Caplan AJ, et al. (1992 Sep 15). Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.

Hon T, et al. (2001 Dec). The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme.

Li J, et al. (2003 Dec). The crystal structure of the yeast Hsp40 Ydj1 complexed with its peptide substrate.

Wu Y, et al. (2005 Mar 4). The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02903
EOG8N2Z4N

sce:MDJ1

Genes: 33

SGD Description
Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones


PomBase Description
mitochondrial DNAJ domain protein Mdj1 (predicted)


AspGD Description
Ortholog(s) have mitochondrion localization


References

Rowley N, et al. (1994 Apr 22). Mdj1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding.

Deloche O, et al. (1997 Nov 7). Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02904
EOG8N2Z4N

sce:SCJ1

Genes: 33

SGD Description
One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins


PomBase Description
DNAJ domain protein Scj1 (predicted)


AspGD Description
Protein with similarity to similar to dnaJ protein; expression induced by tunicamycin and DTT


References

Blumberg H, et al. (1991 Feb 14). A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast.

Schlenstedt G, et al. (1995 May). A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s.

Silberstein S, et al. (1998 Nov 16). A role for the DnaJ homologue Scj1p in protein folding in the yeast endoplasmic reticulum.

Nishikawa SI, et al. (2001 May 28). Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02905
EOG8N2Z4N

sce:HLJ1

Genes: 33

SGD Description
Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ


PomBase Description
DNAJ/DUF1977 DNAJB12 homolog (predicted)


AspGD Description
Putative DnaJ co-chaperone; expression enhanced by maltose


References

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%

FOG02906
EOG8N2Z4N

sce:XDJ1

Genes: 31

SGD Description
Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies


PomBase Description
DNAJ protein Xdj1 (predicted)


AspGD Description
Ortholog(s) have endoplasmic reticulum localization


References

Schwarz E, et al. (1994 Jul 22). XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae.

Burri L, et al. (2006 Apr). Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02907
EOG8N2Z4N

sce:PPT1

Genes: 29

SGD Description
Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth


PomBase Description
serine/threonine protein phosphatase (predicted)


AspGD Description
Ortholog(s) have role in dephosphorylation


References

Chen MX, et al. (1992 Jul 13). Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases.

Chen MX, et al. (1994 Sep 15). A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

Jeong JY, et al. (2003 Mar 28). Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5.

Suhre MH, et al. (2006 Aug 15). Expression, purification and refolding of the phosphatase domain of protein phosphatase 1 (Ppt1) from Saccharomyces cerevisiae.

Wandinger SK, et al. (2006 Jan 25). The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.

Son S, et al. (2009 Apr). Analysis of all protein phosphatase genes in Aspergillus nidulans identifies a new mitotic regulator, fcp1.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02908
EOG8N2Z4N

sce:SGT2

Genes: 26

SGD Description
Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress


PomBase Description
TPR repeat protein, SGT2 family (predicted)


AspGD Description
Ortholog(s) have protein complex scaffold activity, role in posttranslational protein targeting to membrane, response to heat and TRC complex, nucleus localization


References

Angeletti PC, et al. (2002 Jul). Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity.

Liou ST, et al. (2007 Spring). SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces cerevisiae.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02909
EOG8N2Z4N

sce:STI1

Genes: 25

SGD Description
Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop


PomBase Description
chaperone activator Sti1 (predicted)


AspGD Description
Stress-induced protein


References

Nicolet CM, et al. (1989 Sep). Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae.

Hirano T, et al. (1990 Jan 26). Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+.

Boguski MS, et al. (1990 Jul 12). Expanding family.

Smith DF, et al. (1993 Feb). Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70.

Yamashita YM, et al. (1996 Nov 21). 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Ishida M, et al. (2013 Oct). Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02910
EOG8N2Z4N

sce:absent

Genes: 24

PomBase Description
DNAJ protein Spf31 (predicted)


AspGD Description
Ortholog(s) have nucleus localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02911
EOG8N2Z4N

sce:absent

Genes: 9

PomBase Description
DNAJ/TPR domain protein DNAJC7 family


AspGD Description
Ortholog(s) have cytosol localization


References

Pardo M, et al. (2005 Apr 15). The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02912
EOG8N2Z4N

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02913
EOG8N2Z4N

sce:APJ1

Genes: 5

SGD Description
Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress


References

Walsh P, et al. (2004 Jun). The J-protein family: modulating protein assembly, disassembly and translocation.

Sahi C, et al. (2007 Apr 24). Network of general and specialty J protein chaperones of the yeast cytosol.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02914
EOG8N2Z4N

sce:absent

Genes: 2

AspGD Description
Ortholog of A. fumigatus Af293 : Afu6g09500, A. niger CBS 513.88 : An12g06970, Neosartorya fischeri NRRL 181 : NFIA_055150 and Aspergillus fumigatus A1163 : AFUB_075550|Ortholog of A. fumigatus Af293 : Afu6g09500, A. niger CBS 513.88 : An05g02130, Neosartorya fischeri NRRL 181 : NFIA_055150 and Aspergillus fumigatus A1163 : AFUB_075550

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02915
EOG8N2Z4N

sce:absent

Genes: 6

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN4206, A. fumigatus Af293 : Afu1g06020, Aspergillus wentii : Aspwe1_0026071, Aspergillus sydowii : Aspsy1_0059171 and Aspergillus terreus NIH2624 : ATET_03025

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%