FOG02778
EOG8BZKJD

sce:NHX1

Genes: 34

SGD Description
Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism


PomBase Description
CPA1 sodium ion/proton antiporter (predicted)


AspGD Description
Ortholog(s) have potassium:proton antiporter activity, sodium:proton antiporter activity and role in potassium ion transmembrane transport, sodium ion transmembrane transport, vacuolar acidification


References

Raymond CK, et al. (1992 Dec). Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

Nass R, et al. (1997 Oct 17). Intracellular sequestration of sodium by a novel Na+/H+ exchanger in yeast is enhanced by mutations in the plasma membrane H+-ATPase. Insights into mechanisms of sodium tolerance.

Nass R, et al. (1998 Aug 14). Novel localization of a Na+/H+ exchanger in a late endosomal compartment of yeast. Implications for vacuole biogenesis.

Numata M, et al. (1998 Mar 20). Identification of a mitochondrial Na+/H+ exchanger.

Nass R, et al. (1999 Nov). The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock.

Bowers K, et al. (2000 Dec). The sodium/proton exchanger Nhx1p is required for endosomal protein trafficking in the yeast Saccharomyces cerevisiae.

Darley CP, et al. (2000 Oct 1). Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na+/H+ exchangers.

Wells KM, et al. (2001 Feb 2). The yeast Na+/H+ exchanger Nhx1 is an N-linked glycoprotein. Topological implications.

Ali R, et al. (2004 Feb 6). Inhibition of sodium/proton exchange by a Rab-GTPase-activating protein regulates endosomal traffic in yeast.

Maresova L, et al. (2005 Jan). Physiological characterization of Saccharomyces cerevisiae kha1 deletion mutants.

Brett CL, et al. (2005 Mar). The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking.

Mukherjee S, et al. (2006 Aug 15). Mutational analysis of the intramembranous H10 loop of yeast Nhx1 reveals a critical role in ion homoeostasis and vesicle trafficking.

Cagnac O, et al. (2007 Aug 17). Identification and characterization of Vnx1p, a novel type of vacuolar monovalent cation/H+ antiporter of Saccharomyces cerevisiae.

Hedman JM, et al. (2007 Oct). Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae.

Jennings ML, et al. (2008 Apr). Chloride homeostasis in Saccharomyces cerevisiae: high affinity influx, V-ATPase-dependent sequestration, and identification of a candidate Cl- sensor.

Chen S, et al. (2008 Dec). Cardiolipin mediates cross-talk between mitochondria and the vacuole.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Schroer RJ, et al. (2010 Nov). Natural history of Christianson syndrome.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%