FOG02779
EOG870S0V

sce:FTR1

Genes: 50

SGD Description
High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress


PomBase Description
iron permease Fip1


AspGD Description
Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization|Has domain(s) with predicted iron ion transmembrane transporter activity, role in high-affinity iron ion transmembrane transport and high-affinity iron permease complex localization|Ortholog(s) have ferrous iron transmembrane transporter activity, iron ion transmembrane transporter activity


References

Stearman R, et al. (1996 Mar 15). A permease-oxidase complex involved in high-affinity iron uptake in yeast.

Askwith C, et al. (1997 Jan 3). An oxidase-permease-based iron transport system in Schizosaccharomyces pombe and its expression in Saccharomyces cerevisiae.

Labbé S, et al. (1999 Dec 17). A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.

Pelletier B, et al. (2003 Aug 1). Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system.

Rustici G, et al. (2007). Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Kang WH, et al. (2010 Apr 30). The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.

Pouliot B, et al. (2010 Jan). abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mourer T, et al. (2015 Apr 17). Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.

Wittmann S, et al. (2017 Apr 3). The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 50 genes with posterior transmembrane prediction > 50%

FOG02780
EOG870S0V

sce:FTH1

Genes: 35

SGD Description
Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress


References

Urbanowski JL, et al. (1999 Dec 31). The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%