FOG02776
EOG84B8M8
EOG8D51FZ

sce:CCC1

Genes: 36

SGD Description
Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress


AspGD Description
Ortholog(s) have role in cellular iron ion homeostasis and fungal-type vacuole membrane localization|Ortholog(s) have ferrous iron transmembrane transporter activity, manganese ion transmembrane transporter activity


References

Fu D, et al. (1994 Apr). Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.

Lapinskas PJ, et al. (1996 Aug). The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions.

Pozos TC, et al. (1996 Jul). The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.

Chen OS, et al. (2000 Mar 17). CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation.

Li L, et al. (2001 Aug 3). CCC1 is a transporter that mediates vacuolar iron storage in yeast.

Li L, et al. (2004 Aug 6). A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism.

Puig S, et al. (2005 Jan 14). Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Devasahayam G, et al. (2007 Sep). Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae.

Li L, et al. (2008 Feb). Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 36 genes with posterior transmembrane prediction > 50%

FOG02777
EOG8D51FZ

sce:absent

Genes: 2

PomBase Description
ferrous iron/manganese transmembrane transporter Pcl1


References

Mercier A, et al. (2006 Nov). A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.

Kim KD, et al. (2011 May 20). Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Gabrielli N, et al. (2012 Dec 14). Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Encinar del Dedo J, et al. (2015 Mar). A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.

Su Y, et al. (2017 Jan). Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%