FOG02474
EOG805QJN
EOG80RXWV
EOG869P99

sce:OPT1

Genes: 142

Protein description
ghorx transporter


SGD Description
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family


PomBase Description
OPT oligopeptide transmembrane transporter family Isp4|glutathione transmembrane transporter Pgt1


AspGD Description
Has domain(s) with predicted role in transmembrane transport|Ortholog(s) have oligopeptide transmembrane transporter activity and role in transmembrane transport|Has domain(s) with predicted role in transmembrane transport|Ortholog(s) have glutathione transmembrane transporter activity and role in glutathione import into cell, glutathione transmembrane transport|Ortholog(s) have oligopeptide transporter activity


Suggested Analysis
Very large family requires more algorithms to separate into ortholog groups


References

Hauser M, et al. (2000 Feb 4). Enkephalins are transported by a novel eukaryotic peptide uptake system.

Bourbouloux A, et al. (2000 May 5). Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 142 genes with posterior transmembrane prediction > 50%

FOG02475
EOG80RXWV

sce:OPT2

Genes: 1

SGD Description
Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth


References

Lubkowitz MA, et al. (1998 May). Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters.

Bourbouloux A, et al. (2000 May 5). Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02476
EOG80RXWV

sce:absent

Genes: 7

PomBase Description
OPT oligopeptide transmembrane transporter family protein Opt3


AspGD Description
Has domain(s) with predicted role in transmembrane transport


References

Kitamura K, et al. (2012 Mar). The Ubiquitin ligase Ubr11 is essential for oligopeptide utilization in the fission yeast Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02477
EOG805QJN

sce:MRH1;YRO2;HSP30

Genes: 29

SGD Description
Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid|Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies|Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase


PomBase Description
plasma membrane transmembrane transport regulator (predicted)


AspGD Description
Ortholog(s) have mitochondrion, plasma membrane localization


References

Régnacq M, et al. (1993 May-Jun). Isolation and sequence of HSP30, a yeast heat-shock gene coding for a hydrophobic membrane protein.

Wu K, et al. (2000 Feb 15). Expression and subcellular localization of a membrane protein related to Hsp30p in Saccharomyces cerevisiae.

Navarre C, et al. (2002 Dec). Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%

FOG02478
EOG8ZCRRR

sce:SUS1

Genes: 12

SGD Description
Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP


References

Rodríguez-Navarro S, et al. (2004 Jan 9). Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Fischer T, et al. (2004 Sep). Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery.

Cabal GG, et al. (2006 Jun 8). SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope.

Kastenmayer JP, et al. (2006 Mar). Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae.

Köhler A, et al. (2006 Oct). The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

Chekanova JA, et al. (2008 Jan). Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP.

Köhler A, et al. (2008 Jun). Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export.

González-Aguilera C, et al. (2008 Oct). The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.

Pascual-García P, et al. (2008 Oct 15). Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2.

Jani D, et al. (2009 Mar 27). Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export.

Ellisdon AM, et al. (2010 Feb 5). Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

Cuenca-Bono B, et al. (2010 Mar 15). A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism.

Köhler A, et al. (2010 May 14). Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.

Samara NL, et al. (2010 May 21). Structural insights into the assembly and function of the SAGA deubiquitinating module.

Cuenca-Bono B, et al. (2011 Oct). SUS1 introns are required for efficient mRNA nuclear export in yeast.

Hossain MA, et al. (2011 Oct). Key features of the two-intron Saccharomyces cerevisiae gene SUS1 contribute to its alternative splicing.

Samara NL, et al. (2012 Aug 8). A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

García-Oliver E, et al. (2013 Jun). A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02479
EOG805QJN
EOG8ZCRRR

sce:absent

Genes: 6

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG02480
EOG8ZCRRR

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02481
EOG80RXWV

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted role in transmembrane transport

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02482
EOG869P99

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02483
EOG805QJN

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02484
EOG80RXWV

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted role in transmembrane transport|Has domain(s) with predicted role in transmembrane transport

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02485
EOG8ZCRRR

sce:absent

Genes: 4

PomBase Description
SAGA complex subunit Sus1


References

Helmlinger D, et al. (2008 Nov 15). The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Helmlinger D, et al. (2011 Jun 3). Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Sugiyama T, et al. (2013 Jul). Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Elmore ZC, et al. (2014 Jun 19). Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.

Deng X, et al. (2015 Oct 7). Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02486
EOG869P99

sce:BUD9;BUD8

Genes: 4

SGD Description
Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication|Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication


References

Zahner JE, et al. (1996 Apr). Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae.

Harkins HA, et al. (2001 Aug). Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%