FOG02448
EOG8HQC0N

sce:AGP1

Genes: 177

Protein description
Amino acid transporter


SGD Description
Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication


PomBase Description
amino acid permease Isp5|amino acid transmembrane transporter (predicted)|amino acid transmembrane transporter Aat1|amino acid transmembrane transporter, predicted Meu22|amino-acid permease, unknown|cationic amino acid transmembrane transporter Cat1|plasma membrane amino acid permease Per1


AspGD Description
Ortholog(s) have L-lysine transmembrane transporter activity, L-proline transmembrane transporter activity, arginine transmembrane transporter activity, polyamine transmembrane transporter activity


References

Schreve JL, et al. (1998 May). The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Iraqui I, et al. (1999 Feb). Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Forsberg H, et al. (2001 Feb). Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids.

Watanabe T, et al. (2001 Jun 1). Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.

Matsumoto S, et al. (2002 Jul). Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.

Brachat S, et al. (2003). Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.

Samuelsen CO, et al. (2003 May 27). TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Abdel-Sater F, et al. (2004 Apr). The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae.

Schreve JL, et al. (2004 Jan 16). Yeast Agp2p and Agp3p function as amino acid permeases in poor nutrient conditions.

Pardo M, et al. (2005 Apr 15). The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Roth AF, et al. (2006 Jun 2). Global analysis of protein palmitoylation in yeast.

Breakspear A, et al. (2007 Sep). Aspergillus nidulans conidiation genes dewA, fluG, and stuA are differentially regulated in early vegetative growth.

Iwaki T, et al. (2008 Mar). Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Sasaki M, et al. (2008 Sep). The gap-filling sequence on the left arm of chromosome 2 in fission yeast Schizosaccharomyces pombe.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Nakase M, et al. (2010 May 1). Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe.

Schinko T, et al. (2010 Nov). Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Nakase M, et al. (2012). CUE domain-containing protein Vps901 is required for vacuolar protein transport in Schizosaccharomyces pombe.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Nakase M, et al. (2012 Mar). Intracellular trafficking and ubiquitination of the Schizosaccharomyces pombe amino acid permease Aat1p.

Nakase Y, et al. (2013 Sep 1). The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.

Fang Y, et al. (2014). E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 177 genes with posterior transmembrane prediction > 50%

FOG02449
EOG8HQC0N

sce:TAT2

Genes: 1

SGD Description
High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance


References

Chen XH, et al. (1994 Aug 2). SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth.

Schmidt A, et al. (1994 Oct). Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02450
EOG8HQC0N

sce:SAM3

Genes: 1

SGD Description
High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p


References

Rouillon A, et al. (1999 Oct 1). Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02451
EOG8HQC0N

sce:MMP1

Genes: 1

SGD Description
High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p


References

Rouillon A, et al. (1999 Oct 1). Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02452
EOG8HQC0N

sce:HIP1

Genes: 1

SGD Description
High-affinity histidine permease; also involved in the transport of manganese ions


References

Tanaka J, et al. (1985). The histidine permease gene (HIP1) of Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02453
EOG8HQC0N

sce:GAP1

Genes: 1

SGD Description
General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth


References

Grenson M, et al. (1970 Sep). Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. IV. Evidence for a general amino acid permease.

Jauniaux JC, et al. (1990 May 31). GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repression.

Stanbrough M, et al. (1995 Jan). Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae.

Stanbrough M, et al. (1996 Apr). Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae.

Springael JY, et al. (1998 Jun). Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Stolz J, et al. (1999 Jun 25). The fenpropimorph resistance gene FEN2 from Saccharomyces cerevisiae encodes a plasma membrane H+-pantothenate symporter.

Springael JY, et al. (1999 May). NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains.

Regenberg B, et al. (2000 Sep 15). GAP1, a novel selection and counter-selection marker for multiple gene disruptions in Saccharomyces cerevisiae.

Helliwell SB, et al. (2001 May 14). Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease.

Soetens O, et al. (2001 Nov 23). Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1.

Malkus P, et al. (2002 Dec 23). Concentrative sorting of secretory cargo proteins into COPII-coated vesicles.

Chen EJ, et al. (2002 Nov 12). Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomycescerevisiae.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Nikko E, et al. (2003 Dec 12). Permease recycling and ubiquitination status reveal a particular role for Bro1 in the multivesicular body pathway.

Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Andréasson C, et al. (2004 Feb). Four permeases import proline and the toxic proline analogue azetidine-2-carboxylate into yeast.

Scott PM, et al. (2004 Mar). GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network.

Uemura T, et al. (2005 Mar 25). Uptake of putrescine and spermidine by Gap1p on the plasma membrane in Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Cain NE, et al. (2011 Jun 1). Transport activity-dependent intracellular sorting of the yeast general amino acid permease.

Torbensen R, et al. (2012). Amino acid transporter genes are essential for FLO11-dependent and FLO11-independent biofilm formation and invasive growth in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02454
EOG8HQC0N

sce:TAT1

Genes: 1

SGD Description
Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress


References

Schmidt A, et al. (1994 Oct). Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02455
EOG8HQC0N

sce:GNP1

Genes: 1

SGD Description
High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication


References

Zhu X, et al. (1996 Jul 31). GNP1, the high-affinity glutamine permease of S. cerevisiae.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02456
EOG8HQC0N

sce:BAP3

Genes: 1

SGD Description
Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication


References

Mai B, et al. (1994 May 27). Cloning and chromosomal organization of a gene encoding a putative amino-acid permease from Saccharomyces cerevisiae.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02457
EOG8HQC0N

sce:BAP2

Genes: 1

SGD Description
High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication


References

Grauslund M, et al. (1995 Nov 30). BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiae.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Düring-Olsen L, et al. (1999 Jul). Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02458
EOG8HQC0N

sce:PUT4

Genes: 54

SGD Description
Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells


PomBase Description
proline specific plasma membrane permease Put4 (predicted)


AspGD Description
Ortholog(s) have L-proline transmembrane transporter activity, role in proline transport and Golgi apparatus, endoplasmic reticulum, fungal-type vacuole, plasma membrane localization


References

Vandenbol M, et al. (1989 Nov 15). Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

van Slegtenhorst M, et al. (2004 Mar 26). Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

Weisman R, et al. (2005 Feb). Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

van Slegtenhorst M, et al. (2005 Oct 1). Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M, et al. (2007 Aug 24). The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Laor D, et al. (2014 Mar). Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 54 genes with posterior transmembrane prediction > 50%

FOG02459
EOG8HQC0N

sce:AGP2

Genes: 51

SGD Description
Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes


AspGD Description
Ortholog(s) have role in positive regulation of (R)-carnitine transmembrane transport, positive regulation of polyamine transmembrane transport


References

Nasr F, et al. (1994 Jul). An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase.

van Roermund CW, et al. (1999 Nov 1). Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p.

Lee J, et al. (2002 Jun 30). Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 51 genes with posterior transmembrane prediction > 50%

FOG02460
EOG8HQC0N

sce:ALP1;CAN1;LYP1

Genes: 49

SGD Description
Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication|Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication|Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids


AspGD Description
Has domain(s) with predicted role in amino acid transport, transmembrane transport and integral component of membrane, membrane localization|Ortholog(s) have basic amino acid transmembrane transporter activity, role in basic amino acid transport and mitochondrion localization


References

Hoffmann W, et al. (1985 Sep 25). Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence.

Ahmad M, et al. (1986). Yeast arginine permease: nucleotide sequence of the CAN1 gene.

Opekarová M, et al. (1993 Feb 1). Unidirectional arginine transport in reconstituted plasma-membrane vesicles from yeast overexpressing CAN1.

Sychrova H, et al. (1993 Jul). Cloning and sequencing of the Saccharomyces cerevisiae gene LYP1 coding for a lysine-specific permease.

Sychrova H, et al. (1994 May). APL1, a yeast gene encoding a putative permease for basic amino acids.

Opekarová M, et al. (1997 Jul 15). On the unidirectionality of arginine uptake in the yeast Saccharomyces cerevisiae.

Opekarová M, et al. (1998 Feb). Post-translational fate of CAN1 permease of Saccharomyces cerevisiae.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Regenberg B, et al. (2001 Nov). Amino acid residues important for substrate specificity of the amino acid permeases Can1p and Gnp1p in Saccharomyces cerevisiae.

Opekarová M, et al. (2002 Aug 19). Phosphatidyl ethanolamine is essential for targeting the arginine transporter Can1p to the plasma membrane of yeast.

Malínská K, et al. (2003 Nov). Visualization of protein compartmentation within the plasma membrane of living yeast cells.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hosiner D, et al. (2011 Apr). Pun1p is a metal ion-inducible, calcineurin/Crz1p-regulated plasma membrane protein required for cell wall integrity.

Shi Y, et al. (2011 Nov). Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Beaupere C, et al. (2017 Feb 21). CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 49 genes with posterior transmembrane prediction > 50%

FOG02461
EOG8HQC0N

sce:DIP5

Genes: 43

SGD Description
Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress


PomBase Description
amino acid transmembrane transporter (predicted)


AspGD Description
Ortholog(s) have L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity and role in L-aspartate transport, L-glutamate transport, cellular response to drug


References

Robinson JH, et al. (1972 Apr). Regulation of the acidic amino acid permease of Aspergillus nidulans.

Robinson JH, et al. (1973 Nov). The acidic amino-acid permease of Aspergillus nidulans.

Regenberg B, et al. (1999 Dec). Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Apostolaki A, et al. (2009 Mar). AgtA, the dicarboxylic amino acid transporter of Aspergillus nidulans, is concertedly down-regulated by exquisite sensitivity to nitrogen metabolite repression and ammonium-elicited endocytosis.

Abenza JF, et al. (2010 Aug 1). Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes.

Hervás-Aguilar A, et al. (2010 Jul). Characterization of Aspergillus nidulans DidB Did2, a non-essential component of the multivesicular body pathway.

Roumelioti K, et al. (2010 Mar). A cryptic role of a glycolytic-gluconeogenic enzyme (aldolase) in amino acid transporter turnover in Aspergillus nidulans.

Schinko T, et al. (2010 Nov). Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.

Pantazopoulou A, et al. (2011 Apr). Characterization of Aspergillus nidulans RabC/Rab6.

Calcagno-Pizarelli AM, et al. (2011 Dec 1). Rescue of Aspergillus nidulans severely debilitating null mutations in ESCRT-0, I, II and III genes by inactivation of a salt-tolerance pathway allows examination of ESCRT gene roles in pH signalling.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Apostolaki A, et al. (2012 May). Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane.

Karachaliou M, et al. (2013 Apr). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 42 genes with posterior transmembrane prediction > 50%

FOG02462
EOG8HQC0N

sce:AGP3

Genes: 35

SGD Description
Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition


PomBase Description
amino acid transmembrane transporter (predicted)


References

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%

FOG02463
EOG8HQC0N

sce:absent

Genes: 21

AspGD Description
Ortholog(s) have L-proline transmembrane transporter activity, role in proline transport and fungal-type vacuole, plasma membrane localization|Ortholog(s) have L-proline transmembrane transporter activity, role in proline transport and fungal-type vacuole, plasma membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%

FOG02464
EOG8HQC0N

sce:absent

Genes: 18

PomBase Description
amino acid permease (predicted)


AspGD Description
Ortholog(s) have L-cystine transmembrane transporter activity, role in amino acid transmembrane transport and endoplasmic reticulum localization|Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, amino acid transport, transmembrane transport and integral component of membrane, membrane localization


References

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%

FOG02465
EOG8HQC0N

sce:absent

Genes: 10

AspGD Description
Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization


References

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 10 genes with posterior transmembrane prediction > 50%

FOG02466
EOG8HQC0N

sce:absent

Genes: 3

AspGD Description
Ortholog(s) have L-proline transmembrane transporter activity, role in proline transport and fungal-type vacuole, plasma membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02467
EOG8HQC0N

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization|Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02468
EOG8HQC0N

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG02469
EOG8HQC0N

sce:absent

Genes: 7

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02470
EOG8HQC0N

sce:SSY1

Genes: 29

SGD Description
Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p


References

Didion T, et al. (1998 Feb). The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae.

Jørgensen MU, et al. (1998 Jan 30). Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast.

Klasson H, et al. (1999 Aug). Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids.

Iraqui I, et al. (1999 Feb). Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease.

Forsberg H, et al. (2001 Feb). Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids.

Forsberg H, et al. (2001 Oct). The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids.

Andréasson C, et al. (2002 Dec 15). Receptor-mediated endoproteolytic activation of two transcription factors in yeast.

Kodama Y, et al. (2002 May). Genome-wide expression analysis of genes affected by amino acid sensor Ssy1p in Saccharomyces cerevisiae.

Gaber RF, et al. (2003 Oct). Constitutive and hyperresponsive signaling by mutant forms of Saccharomyces cerevisiae amino acid sensor Ssy1.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Liu Z, et al. (2008 Jan). Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%

FOG02471
EOG8HQC0N

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, amino acid transport, transmembrane transport and integral component of membrane, membrane localization|Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, amino acid transport, transmembrane transport and integral component of membrane, membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02472
EOG8HQC0N

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02473
EOG8HQC0N

sce:absent

Genes: 8

PomBase Description
APC amino acid transmembrane transporter (predicted)


AspGD Description
Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization|Has domain(s) with predicted amino acid transmembrane transporter activity, role in amino acid transmembrane transport, transmembrane transport and membrane localization


References

Kashiwazaki J, et al. (2011 Oct). Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%