FOG02438
EOG80GB6D
EOG82JMF9
sce:PDR10;PDR15;PDR18;PDR5;SNQ2
Genes: 144
EOG80GB6D
EOG82JMF9
sce:PDR10;PDR15;PDR18;PDR5;SNQ2
Genes: 144
Protein description
abc transporter
SGD Description
ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p|Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication|Putative transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies|Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication|Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
PomBase Description
ABC transmembrane transporter Pdr1|brefeldin A transmembrane transporter Bfr1
AspGD Description
Ortholog(s) have role in cellular response to drug, fluconazole transport and plasma membrane localization|Ortholog(s) have ATP binding, drug binding, drug transmembrane transporter activity, fluconazole transporter activity, phospholipid-translocating ATPase activity|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Ortholog(s) have ATP binding, drug binding, fluconazole transporter activity, phospholipid-translocating ATPase activity, xenobiotic-transporting ATPase activity|Ortholog(s) have role in drug transmembrane transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport
References
Balzi E, et al. (1987 Dec 15). The multidrug resistance gene PDR1 from Saccharomyces cerevisiae.
Meyers S, et al. (1992 May). Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5.
Servos J, et al. (1993 Jan). Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases.
Decottignies A, et al. (1994 Apr 29). Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast.
Bissinger PH, et al. (1994 Feb 11). Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.
Balzi E, et al. (1994 Jan 21). PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.
Katzmann DJ, et al. (1994 Jul). Transcriptional control of the yeast PDR5 gene by the PDR3 gene product.
Hirata D, et al. (1994 Oct). Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance.
Leonard PJ, et al. (1994 Oct). Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.
Delahodde A, et al. (1995 Aug). Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance.
Decottignies A, et al. (1995 Jul 28). Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.
Kralli A, et al. (1995 May 9). LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.
Egner R, et al. (1995 Nov). Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.
Albertson GD, et al. (1996 Dec). Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance.
Miyahara K, et al. (1996 Dec 16). The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance.
Kolaczkowski M, et al. (1996 Dec 6). Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p.
Miyahara K, et al. (1996 Jan). yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae.
Egner R, et al. (1996 Jan 8). The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole.
Kralli A, et al. (1996 Jul 19). An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones.
Sanglard D, et al. (1996 Oct). Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors.
Mahé Y, et al. (1996 Oct 11). The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo.
Del Sorbo G, et al. (1997 Apr 28). Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters.
Decottignies A, et al. (1997 Feb). Complete inventory of the yeast ABC proteins.
Reid RJ, et al. (1997 May 2). Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.
Carvajal E, et al. (1997 Oct). Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes.
Nourani A, et al. (1997 Oct). Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain.
Ogawa A, et al. (1998 Apr). Role of ABC transporters in aureobasidin A resistance.
Hernáez ML, et al. (1998 Apr 30). Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals.
Krishnamurthy S, et al. (1998 Apr 30). Deletion of transmembrane domain 12 of CDR1, a multidrug transporter from Candida albicans, leads to altered drug specificity: expression of a yeast multidrug transporter in baculovirus expression system.
Plemper RK, et al. (1998 Dec 4). Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.
Kolaczkowski M, et al. (1998 Fall). In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network.
Egner R, et al. (1998 Feb). Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.
Krishnamurthy S, et al. (1998 Jan 1). Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans, belonging to the ATP binding cassette super family.
Miyazaki H, et al. (1998 Jul). Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.
Krishnamurthy S, et al. (1998 Mar 15). Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones.
Smriti, et al. (1999 Apr 15). Membrane fluidity affects functions of Cdr1p, a multidrug ABC transporter of Candida albicans.
Henry KW, et al. (1999 Aug). Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents.
Decottignies A, et al. (1999 Dec 24). Casein kinase I-dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p.
Dogra S, et al. (1999 Jan 30). Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily.
Puri N, et al. (1999 Nov 15). CDR1, a multidrug resistance gene from Candida albicans, contains multiple regulatory domains in its promoter and the distal AP-1 element mediates its induction by miconazole.
Andrade AC, et al. (2000 Aug). The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds.
Michalkova-Papajova D, et al. (2000 Feb). Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin.
Golin J, et al. (2000 Jan). Chemical specificity of the PDR5 multidrug resistance gene product of Saccharomyces cerevisiae based on studies with tri-n-alkyltin chlorides.
Del Sorbo G, et al. (2000 Jun). Fungal transporters involved in efflux of natural toxic compounds and fungicides.
Conseil G, et al. (2000 Jun 13). Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae.
Egner R, et al. (2000 Mar). The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.
DeRisi J, et al. (2000 Mar 24). Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants.
Lyons CN, et al. (2000 Sep). Transcriptional analyses of antifungal drug resistance in Candida albicans.
Rogers B, et al. (2001 Apr). The pleitropic drug ABC transporters from Saccharomyces cerevisiae.
Nakamura K, et al. (2001 Dec). Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters.
Zhang X, et al. (2001 Dec 21). Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase.
Conseil G, et al. (2001 Feb 27). Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.
Hiraga K, et al. (2001 Jul). A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae.
Hu W, et al. (2001 Jun). The ABC transporter Pdr5p mediates the efflux of nonsteroidal ecdysone agonists in Saccharomyces cerevisiae.
Wanigasekera A, et al. (2001 Oct). Purification and some properties of an inhibitor for a yeast pleiotropic drug resistant pump from Kitasatospora sp. E-420.
Nakaune R, et al. (2002 Apr). A novel ABC transporter gene, PMR5, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum.
Navarre C, et al. (2002 Dec). Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae.
Akache B, et al. (2002 Jun 14). New regulators of drug sensitivity in the family of yeast zinc cluster proteins.
Semighini CP, et al. (2002 Mar). Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay.
de Micheli M, et al. (2002 Mar). A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance.
Smriti, et al. (2002 Mar 15). ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators.
Hellauer K, et al. (2002 May 17). Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter.
Ferreira-Pereira A, et al. (2003 Apr 4). Three-dimensional reconstruction of the Saccharomyces cerevisiae multidrug resistance protein Pdr5p.
Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.
Gupta SS, et al. (2003 Aug 1). Antifungal activity of amiodarone is mediated by disruption of calcium homeostasis.
Conseil G, et al. (2003 Aug 7). Potent competitive inhibition of drug binding to the Saccharomyces cerevisiae ABC exporter Pdr5p by the hydrophobic estradiol-derivative RU49953.
Shukla S, et al. (2003 Dec). Functional characterization of Candida albicans ABC transporter Cdr1p.
Golin J, et al. (2003 Feb 21). Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux.
Hikkel I, et al. (2003 Mar 28). A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast.
Gauthier C, et al. (2003 May). Functional similarities and differences between Candida albicans Cdr1p and Cdr2p transporters.
Schnabel G, et al. (2003 Oct). Cloning and expression analysis of the ATP-binding cassette transporter gene MFABC1 and the alternative oxidase gene MfAOX1 from Monilinia fructicola.
Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
Lichtenberg-Fraté H, et al. (2003 Oct-Dec). A yeast-based method for the detection of cyto and genotoxicity.
Kolaczkowski M, et al. (2003 Sep). Phenothiazines as potent modulators of yeast multidrug resistance.
Jha S, et al. (2003 Sep 16). Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis.
Niimi K, et al. (2004 Apr). Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative.
Karababa M, et al. (2004 Aug). Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.
Chen CG, et al. (2004 Dec). CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1.
Coste AT, et al. (2004 Dec). TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.
Niimi M, et al. (2004 Dec). Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance.
Karnani N, et al. (2004 Feb). SRE1 and SRE2 are two specific steroid-responsive modules of Candida drug resistance gene 1 (CDR1) promoter.
Mamnun YM, et al. (2004 Feb 13). Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase.
Gaur NA, et al. (2004 Jan). Identification of a negative regulatory element which regulates basal transcription of a multidrug resistance gene CDR1 of Candida albicans.
Shukla S, et al. (2004 Jul). Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.
Wehrschütz-Sigl E, et al. (2004 Mar). The transporters Pdr5p and Snq2p mediate diazaborine resistance and are under the control of the gain-of-function allele PDR1-12.
O'Keeffe J, et al. (2004 Mar-Apr). Adriamycin alters the expression of drug efflux pumps and confers amphotericin B tolerance in Candida albicans.
Semighini CP, et al. (2004 Oct). Multi-copy suppression of an Aspergillus nidulans mutant sensitive to camptothecin by a putative monocarboxylate transporter.
Gao C, et al. (2004 Oct 8). On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae: evidence for enhanced recruitment of coactivators and altered nucleosome structures.
Mateus C, et al. (2004 Sep). Adherence of Candida albicans to silicone induces immediate enhanced tolerance to fluconazole.
Shukla S, et al. (2004 Sep 17). Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.
Malác J, et al. (2005 Dec). Activity of yeast multidrug resistance pumps during growth is controlled by carbon source and the composition of growth-depleted medium: DiS-C3(3) fluorescence assay.
Saini P, et al. (2005 Jul). Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux.
Moye-Rowley WS, et al. (2005 Jul 18). Retrograde regulation of multidrug resistance in Saccharomyces cerevisiae.
Hanson L, et al. (2005 Jul 19). The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.
Gaur NA, et al. (2005 Jun 24). Expression of the CDR1 efflux pump in clinical Candida albicans isolates is controlled by a negative regulatory element.
Lucau-Danila A, et al. (2005 Mar). Early expression of yeast genes affected by chemical stress.
Hiraga K, et al. (2005 Mar 25). Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae.
Tutulan-Cunita AC, et al. (2005 May). Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity.
Rai V, et al. (2005 May 3). Functional characterization of N-terminal nucleotide binding domain (NBD-1) of a major ABC drug transporter Cdr1p of Candida albicans: uncommon but conserved Trp326 of Walker B is important for ATP binding.
Yamamoto S, et al. (2005 May 6). A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae.
Sano T, et al. (2005 Nov 4). Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants.
Lepak A, et al. (2006 Apr). Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole.
Larsen B, et al. (2006 Aug). Key physiological differences in Candida albicans CDR1 induction by steroid hormones and antifungal drugs.
Souid AK, et al. (2006 Aug). ELM1 is required for multidrug resistance in Saccharomyces cerevisiae.
Alenquer M, et al. (2006 Dec). Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5.
Shukla S, et al. (2006 Feb 21). Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.
Cheng G, et al. (2006 Jan). Cellular and molecular biology of Candida albicans estrogen response.
Tanida T, et al. (2006 Jan). Antimicrobial peptides enhance the candidacidal activity of antifungal drugs by promoting the efflux of ATP from Candida cells.
Gao PH, et al. (2006 Jul). Drug susceptibilities of yeast cells are affected when expressing mutant Candida albicans drug resistance protein.
Yang YL, et al. (2006 Jul 13). Serum repressing efflux pump CDR1 in Candida albicans.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Teixeira MC, et al. (2006 Mar). Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid.
de Waard MA, et al. (2006 Mar). Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence.
Saini P, et al. (2006 May). Chimeras of the ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide-binding domains, but transmembrane segment 12 is replaceable with the corresponding homologous region of the non-drug transporter Cdr3p.
Wang JS, et al. (2006 Oct). The DNA-binding domain of CaNdt80p is required to activate CDR1 involved in drug resistance in Candida albicans.
Golin J, et al. (2007 Apr 27). The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?
de Thozée CP, et al. (2007 Feb). Subcellular trafficking of the yeast plasma membrane ABC transporter, Pdr5, is impaired by a mutation in the N-terminal nucleotide-binding fold.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Fardeau V, et al. (2007 Feb 16). The central role of PDR1 in the foundation of yeast drug resistance.
Shen H, et al. (2007 Jan). Fcr1p inhibits development of fluconazole resistance in Candida albicans by abolishing CDR1 induction.
Shukla S, et al. (2007 Oct 30). Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system.
Manoharlal R, et al. (2008 Apr). Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans.
Pasrija R, et al. (2008 Feb). Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts.
Holmes AR, et al. (2008 Nov). ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.
Tsao S, et al. (2009 Apr). Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.
Zhang H, et al. (2009 May). Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps.
Puri N, et al. (2009 Sep). The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.
Siikala E, et al. (2010 Dec). Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.
Sun LM, et al. (2010 Jan). Synergistic mechanisms of retigeric acid B and azoles against Candida albicans.
Basso LR Jr, et al. (2010 Jun). Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p.
Kumar A, et al. (2010 Sep). Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.
Zhu J, et al. (2011). Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione.
Kofla G, et al. (2011 Feb). Doxorubicin induces drug efflux pumps in Candida albicans.
Manoharlal R, et al. (2011 Feb). Molecular determinants of transient and reversible induced up-regulation of CaCDR1 in azole susceptible clinical isolates of Candida albicans.
Shukla S, et al. (2011 Oct). Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans.
Watamoto T, et al. (2011 Sep). Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals.
Prasad R, et al. (2012 Jan 6). Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Coradetti ST, et al. (2013 Aug). Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.
Rawal MK, et al. (2013 Aug 23). Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.
Sun X, et al. (2013 May). PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.
Thomas E, et al. (2013 Nov). Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
139 genes with posterior transmembrane prediction > 50% |
||
FOG02439
EOG80GB6D
sce:PDR12
Genes: 27
EOG80GB6D
sce:PDR12
Genes: 27
SGD Description
Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
References
Piper P, et al. (1998 Aug 3). The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast.
Holyoak CD, et al. (1999 Aug). The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism.
Holyoak CD, et al. (2000 Aug). Loss of Cmk1 Ca(2+)-calmodulin-dependent protein kinase in yeast results in constitutive weak organic acid resistance, associated with a post-transcriptional activation of the Pdr12 ATP-binding cassette transporter.
Bauer BE, et al. (2003 Aug). Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants.
Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.
Kren A, et al. (2003 Mar). War1p, a novel transcription factor controlling weak acid stress response in yeast.
Hatzixanthis K, et al. (2003 May). Moderately lipophilic carboxylate compounds are the selective inducers of the Saccharomyces cerevisiae Pdr12p ATP-binding cassette transporter.
Schüller C, et al. (2004 Feb). Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae.
Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Hazelwood LA, et al. (2006 Sep). A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism.
Papadimitriou MN, et al. (2007 Jan 25). High Pdr12 levels in spoilage yeast (Saccharomyces cerevisiae) correlate directly with sorbic acid levels in the culture medium but are not sufficient to provide cells with acquired resistance to the food preservative.
Gregori C, et al. (2007 Jun). A genetic screen identifies mutations in the yeast WAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation.
Lushchak V, et al. (2008). Pdr12p-dependent and -independent fluorescein extrusion from baker's yeast cells.
Gregori C, et al. (2008 Sep 12). Weak organic acids trigger conformational changes of the yeast transcription factor War1 in vivo to elicit stress adaptation.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
27 genes with posterior transmembrane prediction > 50% |
||
FOG02440
EOG80GB6D
sce:AUS1
Genes: 1
EOG80GB6D
sce:AUS1
Genes: 1
SGD Description
Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication
References
Wilcox LJ, et al. (2002 Sep 6). Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG02441
EOG80GB6D
sce:PDR11
Genes: 1
EOG80GB6D
sce:PDR11
Genes: 1
SGD Description
ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication
References
Decottignies A, et al. (1995 Jul 28). Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.
Wilcox LJ, et al. (2002 Sep 6). Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG02442
EOG80GB6D
sce:absent
Genes: 3
EOG80GB6D
sce:absent
Genes: 3
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG02443
EOG80GB6D
sce:absent
Genes: 7
EOG80GB6D
sce:absent
Genes: 7
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
7 genes with posterior transmembrane prediction > 50% |
||
FOG02444
EOG80GB6D
sce:absent
Genes: 8
EOG80GB6D
sce:absent
Genes: 8
AspGD Description
Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport|Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport
References
Del Sorbo G, et al. (1997 Apr 28). Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters.
Del Sorbo G, et al. (2000 Jun). Fungal transporters involved in efflux of natural toxic compounds and fungicides.
Semighini CP, et al. (2002 Mar). Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay.
Semighini CP, et al. (2004 Oct). Multi-copy suppression of an Aspergillus nidulans mutant sensitive to camptothecin by a putative monocarboxylate transporter.
Christians JK, et al. (2011 Apr 29). Quantitative trait locus (QTL) mapping reveals a role for unstudied genes in Aspergillus virulence.
de Castro Pimentel Figueiredo B, et al. (2011 Feb). The Aspergillus nidulans nucA(EndoG) homologue is not involved in cell death.
Garzia A, et al. (2013 Feb). Transcriptional changes in the transition from vegetative cells to asexual development in the model fungus Aspergillus nidulans.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
8 genes with posterior transmembrane prediction > 50% |
||
FOG02445
EOG80GB6D
sce:absent
Genes: 6
EOG80GB6D
sce:absent
Genes: 6
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
||
FOG02446
EOG80GB6D
sce:absent
Genes: 5
EOG80GB6D
sce:absent
Genes: 5
AspGD Description
Protein similar to brefeldin A resistance protein Bfr1 of S. pombe
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
||
FOG02447
EOG80GB6D
sce:absent
Genes: 5
EOG80GB6D
sce:absent
Genes: 5
AspGD Description
Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
||
