FOG02253
EOG80RXWR
EOG8G79D4
EOG8NGF2P
EOG8NP5KN
EOG8QJQ3W
EOG8VHHNC
EOG8XWDD8
sce:FRE2;FRE3;FRE4;FRE5
Genes: 113
EOG80RXWR
EOG8G79D4
EOG8NGF2P
EOG8NP5KN
EOG8QJQ3W
EOG8VHHNC
EOG8XWDD8
sce:FRE2;FRE3;FRE4;FRE5
Genes: 113
SGD Description
Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels|Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels|Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels|Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process|Ortholog(s) have endoplasmic reticulum localization|Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process|Ortholog(s) have ferric-chelate reductase activity, role in cellular iron ion homeostasis, cellular response to iron ion starvation, siderophore transport and plasma membrane localization
References
Georgatsou E, et al. (1994 May). Two distinctly regulated genes are required for ferric reduction, the first step of iron uptake in Saccharomyces cerevisiae.
Yamaguchi-Iwai Y, et al. (1995 Mar 15). AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.
Casas C, et al. (1997 Jun 15). The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.
Georgatsou E, et al. (1997 May 23). The yeast Fre1p/Fre2p cupric reductases facilitate copper uptake and are regulated by the copper-modulated Mac1p activator.
Martins LJ, et al. (1998 Sep 11). Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae.
Georgatsou E, et al. (1999 May). Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes.
Yun CW, et al. (2001 Mar 30). The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae.
Oberegger H, et al. (2002 Nov). Regulation of freA, acoA, lysF, and cycA expression by iron availability in Aspergillus nidulans.
Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.
Courel M, et al. (2005 Aug). Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.
Aguirre J, et al. (2005 Mar). Reactive oxygen species and development in microbial eukaryotes.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Semighini CP, et al. (2008 Aug). Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen species.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
113 genes with posterior transmembrane prediction > 50% |
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FOG02254
sce:absent
Genes: 0
sce:absent
Genes: 0
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02255
sce:absent
Genes: 0
sce:absent
Genes: 0
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02256
EOG8XWDD8
sce:absent
Genes: 5
EOG8XWDD8
sce:absent
Genes: 5
Protein description
NADPH oxidase
AspGD Description
Putative NADPH oxidase
References
Lara-Ortíz T, et al. (2003 Nov). Reactive oxygen species generated by microbial NADPH oxidase NoxA regulate sexual development in Aspergillus nidulans.
Aguirre J, et al. (2005 Mar). Reactive oxygen species and development in microbial eukaryotes.
Han KH, et al. (2009 Sep). Molecular Genetics of Emericella nidulans Sexual Development.
Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.
Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.
Arratia-Quijada J, et al. (2012 Sep). FlbD, a Myb transcription factor of Aspergillus nidulans, is uniquely involved in both asexual and sexual differentiation.
Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.
Sun X, et al. (2013 May). PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
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FOG02257
EOG8XWDD8
sce:absent
Genes: 4
EOG8XWDD8
sce:absent
Genes: 4
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG02258
EOG8G79D4
EOG8NP5KN
sce:FRE1
Genes: 16
EOG8G79D4
EOG8NP5KN
sce:FRE1
Genes: 16
SGD Description
Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
References
Anderson GJ, et al. (1992 Aug 15-Sep). Ferric iron reduction and iron assimilation in Saccharomyces cerevisiae.
Dancis A, et al. (1992 May 1). Ferric reductase of Saccharomyces cerevisiae: molecular characterization, role in iron uptake, and transcriptional control by iron.
Hassett R, et al. (1995 Jan 6). Evidence for Cu(II) reduction as a component of copper uptake by Saccharomyces cerevisiae.
Yamaguchi-Iwai Y, et al. (1995 Mar 15). AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.
Finegold AA, et al. (1996 Dec 6). Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase.
Shatwell KP, et al. (1996 Jun 14). The FRE1 ferric reductase of Saccharomyces cerevisiae is a cytochrome b similar to that of NADPH oxidase.
Lesuisse E, et al. (1996 Jun 7). Evidence for the Saccharomyces cerevisiae ferrireductase system being a multicomponent electron transport chain.
Casas C, et al. (1997 Jun 15). The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.
Georgatsou E, et al. (1997 May 23). The yeast Fre1p/Fre2p cupric reductases facilitate copper uptake and are regulated by the copper-modulated Mac1p activator.
Martins LJ, et al. (1998 Sep 11). Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae.
Georgatsou E, et al. (1999 May). Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes.
Yun CW, et al. (2001 Mar 30). The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae.
Shi X, et al. (2003 Dec 12). Fre1p Cu2+ reduction and Fet3p Cu1+ oxidation modulate copper toxicity in Saccharomyces cerevisiae.
Shinyashiki M, et al. (2004 Sep 1). Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO.
Courel M, et al. (2005 Aug). Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.
Ramalho PA, et al. (2005 Jul). Azo reductase activity of intact saccharomyces cerevisiae cells is dependent on the Fre1p component of plasma membrane ferric reductase.
Aronova S, et al. (2007 Aug). Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
16 genes with posterior transmembrane prediction > 50% |
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FOG02259
EOG8QJQ3W
sce:absent
Genes: 4
EOG8QJQ3W
sce:absent
Genes: 4
AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process
References
Semighini CP, et al. (2008 Aug). Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen species.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
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FOG02260
EOG8NGF2P
EOG8S1RP9
sce:absent
Genes: 6
EOG8NGF2P
EOG8S1RP9
sce:absent
Genes: 6
AspGD Description
Ortholog(s) have ferric-chelate reductase activity and role in cellular iron ion homeostasis, cellular response to iron ion starvation
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
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FOG02261
sce:absent
Genes: 0
sce:absent
Genes: 0
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02262
sce:absent
Genes: 0
sce:absent
Genes: 0
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02263
EOG8QJQ3W
sce:absent
Genes: 1
EOG8QJQ3W
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02264
EOG8XWDD8
sce:absent
Genes: 1
EOG8XWDD8
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02265
EOG8G79D4
sce:FRE6
Genes: 1
EOG8G79D4
sce:FRE6
Genes: 1
SGD Description
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
References
Martins LJ, et al. (1998 Sep 11). Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae.
Georgatsou E, et al. (1999 May). Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes.
Courel M, et al. (2005 Aug). Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Rees EM, et al. (2007 Jul 27). Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization.
Singh A, et al. (2007 Sep 28). The metalloreductase Fre6p in Fe-efflux from the yeast vacuole.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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