FOG02252
EOG86WWRD
EOG8X3FJJ

sce:HST3

Genes: 32

SGD Description
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism


References

Brachmann CB, et al. (1995 Dec 1). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

Smith JS, et al. (2000 Jun 6). A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Celic I, et al. (2006 Jul 11). The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

Pan X, et al. (2006 Mar 10). A DNA integrity network in the yeast Saccharomyces cerevisiae.

Miller KM, et al. (2006 Nov). Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%