FOG02251
EOG8SF7QQ

sce:HST4

Genes: 23

SGD Description
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism


PomBase Description
Sirtuin family histone deacetylase Hst4


AspGD Description
Ortholog(s) have NAD-dependent histone deacetylase activity


References

Brachmann CB, et al. (1995 Dec 1). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

Derbyshire MK, et al. (1996 Jun 15). HST1, a new member of the SIR2 family of genes.

Freeman-Cook LL, et al. (1999 Oct). The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.

Smith JS, et al. (2000 Jun 6). A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Wirén M, et al. (2005 Aug 17). Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.

Celic I, et al. (2006 Jul 11). The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.

Pan X, et al. (2006 Mar 10). A DNA integrity network in the yeast Saccharomyces cerevisiae.

Miller KM, et al. (2006 Nov). Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4.

Durand-Dubief M, et al. (2007 May 16). Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.

Xhemalce B, et al. (2007 May 18). Regulation of histone H3 lysine 56 acetylation in Schizosaccharomyces pombe.

Haldar D, et al. (2008 May). Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.

Calonge TM, et al. (2010 May). Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1.

Chang DY, et al. (2011 Jan 21). The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.

Vejrup-Hansen R, et al. (2011 Mar 7). Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Nakamura T, et al. (2012 Sep). Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.

Trickey M, et al. (2013 Jan 11). Anaphase-promoting complex/cyclosome-mediated proteolysis of Ams2 in the G1 phase ensures the coupling of histone gene expression to DNA replication in fission yeast.

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Tapia-Alveal C, et al. (2014 Jun). H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.

Gaspa L, et al. (2016). A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%