FOG02248
EOG8H18BC
sce:HST1;SIR2
Genes: 35
EOG8H18BC
sce:HST1;SIR2
Genes: 35
SGD Description
NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication|Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy; SIR2 has a paralog, HST1, that arose from the whole genome duplication
PomBase Description
Sirtuin family histone deacetylase Sir2
AspGD Description
Ortholog(s) have NAD+ binding, NAD-dependent histone deacetylase activity (H3-K9 specific), NAD-dependent histone deacetylase activity (H4-K16 specific) and histone deacetylase activity (H3-K14 specific), more
References
Shore D, et al. (1984 Dec 1). Characterization of two genes required for the position-effect control of yeast mating-type genes.
Chen XJ, et al. (1994 Jul). sir2 mutants of Kluyveromyces lactis are hypersensitive to DNA-targeting drugs.
Brachmann CB, et al. (1995 Dec 1). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Derbyshire MK, et al. (1996 Jun 15). HST1, a new member of the SIR2 family of genes.
Tsukamoto Y, et al. (1997 Aug 28). Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae.
Gotta M, et al. (1997 Jun 2). Localization of Sir2p: the nucleolus as a compartment for silent information regulators.
Moazed D, et al. (1997 Mar 18). Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.
Shou W, et al. (1999 Apr 16). Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex.
Straight AF, et al. (1999 Apr 16). Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity.
Tanny JC, et al. (1999 Dec 23). An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing.
Xie J, et al. (1999 Nov 15). Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae.
Imai S, et al. (2000 Feb 17). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
Roy N, et al. (2000 Jan 27). Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.
Smith JS, et al. (2000 Jun 6). A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
Sekinger EA, et al. (2001 May 4). Silenced chromatin is permissive to activator binding and PIC recruitment.
Gasser SM, et al. (2001 Nov 14). The molecular biology of the SIR proteins.
Pijnappel WW, et al. (2001 Nov 15). The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.
Cuperus G, et al. (2002 Oct). Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.
Garcia SN, et al. (2002 Oct). A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae.
McCord R, et al. (2003 Mar). Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes.
Bedalov A, et al. (2003 Oct). NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae.
Huang J, et al. (2003 Sep 1). Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing.
Howitz KT, et al. (2003 Sep 11). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Borra MT, et al. (2004 Aug 3). Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
Douglas NL, et al. (2005 Dec). Dual roles for Mcm10 in DNA replication initiation and silencing at the mating-type loci.
Darst RP, et al. (2008 Feb). Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.
Du J, et al. (2009 Apr 7). Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Ha CW, et al. (2012 Jun). Nsi1 plays a significant role in the silencing of ribosomal DNA in Saccharomyces cerevisiae.
Shimizu M, et al. (2012 Sep). Hydrolase controls cellular NAD, sirtuin, and secondary metabolites.
Hsu HC, et al. (2013 Jan 1). Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG02249
EOG8H18BC
sce:HST2
Genes: 31
EOG8H18BC
sce:HST2
Genes: 31
SGD Description
Cytoplasmic NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
PomBase Description
Sirtuin family histone deacetylase Hst2
AspGD Description
Ortholog(s) have protein deacetylase activity and role in chromatin silencing at centromere outer repeat region, chromatin silencing at rDNA, chromatin silencing at telomere, histone H3-K9 deacetylation, phenotypic switching
References
Brachmann CB, et al. (1995 Dec 1). The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Tanner KG, et al. (2000 Dec 19). Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose.
Landry J, et al. (2000 May 23). The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.
Perrod S, et al. (2001 Jan 15). A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast.
Zhao K, et al. (2003 Nov). Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide.
Zhao K, et al. (2003 Oct). Structure and autoregulation of the yeast Hst2 homolog of Sir2.
Borra MT, et al. (2004 Aug 3). Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
Zhao K, et al. (2004 Jun 8). Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases.
Khan AN, et al. (2006 Apr 28). Use of substrate analogs and mutagenesis to study substrate binding and catalysis in the Sir2 family of NAD-dependent protein deacetylases.
Wilson JM, et al. (2006 Dec). Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.
Sanders BD, et al. (2007 Feb 9). Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes.
Liang Z, et al. (2010 Sep 16). Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2?
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG02250
EOG8H18BC
sce:absent
Genes: 2
EOG8H18BC
sce:absent
Genes: 2
References
Pérez-Martín J, et al. (1999 May 4). Phenotypic switching in Candida albicans is controlled by a SIR2 gene.
Low CF, et al. (2008 Dec). Inhibition of hyphae formation and SIR2 expression in Candida albicans treated with fresh Allium sativum (garlic) extract.
Fu XH, et al. (2008 Oct). Candida albicans, a distinctive fungal model for cellular aging study.
Lim CS, et al. (2009 Dec). 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans.
Khodavandi A, et al. (2011 Dec). Expression analysis of SIR2 and SAPs1-4 gene expression in Candida albicans treated with allicin compared to fluconazole.
Rao KH, et al. (2013). N-acetylglucosamine kinase, HXK1 is involved in morphogenetic transition and metabolic gene expression in Candida albicans.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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