FOG02247
EOG89ZW65

sce:CRC1

Genes: 31

SGD Description
Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homology SLC25A20 complements yeast null mutant


AspGD Description
Ortholog(s) have carnitine transmembrane transporter activity, carnitine:acyl carnitine antiporter activity and role in acetate catabolic process, carbon utilization, carnitine transport, fatty acid metabolic process


References

Armitt S, et al. (1976 Feb). Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans.

Payton M, et al. (1976 May). Agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of Aspergillus nidulans.

De Lucas JR, et al. (1997 Dec). Characterization of oleate-nonutilizing mutants of Aspergillus nidulans isolated by the 3-amino-1,2,4-triazole positive selection method.

Palmieri L, et al. (1999 Dec 3). Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae.

De Lucas JR, et al. (1999 May-Jun). The acuH gene of Aspergillus nidulans, required for growth on acetate and long-chain fatty acids, encodes a putative homologue of the mammalian carnitine/acylcarnitine carrier.

van Roermund CW, et al. (1999 Nov 1). Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p.

Ramón De Lucas J, et al. (2001 Jul 24). The Aspergillus nidulans carnitine carrier encoded by the acuH gene is exclusively located in the mitochondria.

Pérez P, et al. (2003 Aug). Functional analysis of mutations in the human carnitine/acylcarnitine translocase in Aspergillus nidulans.

Hynes MJ, et al. (2006 May). Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.

Martínez O, et al. (2007 Feb). Suppression of the acuH13 and acuH31 nonsense mutations in the carnitine/acylcarnitine translocase (acuH) gene of Aspergillus nidulans by the G265S substitution in the domain 2 of the release factor eRF1.

De Lucas JR, et al. (2008 Feb). Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Hynes MJ, et al. (2010 Jul). ATP-citrate lyase is required for production of cytosolic acetyl coenzyme A and development in Aspergillus nidulans.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%