FOG02000
EOG8T1G28

sce:FAS1

Genes: 38

Protein description
Beta subunit of fatty acid synthetase


SGD Description
Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities


PomBase Description
fatty acid synthase beta subunit Fas1


AspGD Description
Has domain(s) with predicted catalytic activity, enoyl-[acyl-carrier-protein] reductase (NADH) activity, fatty acid synthase activity, transferase activity|Putative fatty acid synthase, beta subunit|Ortholog(s) have role in fatty acid biosynthetic process, secondary metabolite biosynthetic process|Has domain(s) with predicted catalytic activity, enoyl-[acyl-carrier-protein] reductase (NADH) activity, fatty acid synthase activity, oxidoreductase activity, transferase activity|ACP acetyltransferase; long chain betahydroxypalmitoyl thioester dehydratase


Suggested Analysis
Enzyme has domains that have concat; find origin of fusion


References

Schweizer M, et al. (1986 Jun). The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains.

Chirala SS, et al. (1987 Mar 25). Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase.

Köttig H, et al. (1991 Apr). The pentafunctional FAS1 genes of Saccharomyces cerevisiae and Yarrowia lipolytica are co-linear and considerably longer than previously estimated.

Carter AT, et al. (1994 Aug). Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae.

Brown DW, et al. (1996 Dec 10). Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.

Niwa H, et al. (1998 Aug). Cloning of the fatty acid synthetase beta subunit from fission yeast, coexpression with the alpha subunit, and purification of the intact multifunctional enzyme complex.

Dessen P, et al. (2000 Feb 22). The PAUSE software for analysis of translational control over protein targeting: application to E. nidulans membrane proteins.

Tsitsigiannis DI, et al. (2007 Mar). Oxylipins as developmental and host-fungal communication signals.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Drogat J, et al. (2012 Nov 29). Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Burr R, et al. (2016 Jun 3). Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Takemoto A, et al. (2016 Mar 15). Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG02001
EOG844J14
EOG8T1G28

sce:FAS2

Genes: 38

Protein description
Alpha subunit of fatty acid synthetase


SGD Description
Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities


PomBase Description
fatty acid synthase alpha subunit Lsd1


AspGD Description
Fatty acid synthase subunit alpha; induced by growth on starch and lactate|Fatty-acid synthase|Fatty-acid synthase|Protein similar to polyketide synthases (PKS-like), encoded in a predicted secondary metabolite gene cluster|Fatty-acid synthase


Suggested Analysis
Enzyme has domains that have concat; find origin of fusion


References

Mohamed AH, et al. (1988 Sep 5). Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

Inokoshi J, et al. (1994 Jul 8). Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene.

Brown DW, et al. (1996 Dec 10). Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.

Tsitsigiannis DI, et al. (2004 Dec). Endogenous lipogenic regulators of spore balance in Aspergillus nidulans.

Wilson RA, et al. (2004 May). Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Mogensen J, et al. (2006 Aug). Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol.

Leibundgut M, et al. (2007 Apr 13). Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase.

Lomakin IB, et al. (2007 Apr 20). The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.

Tsitsigiannis DI, et al. (2007 Mar). Oxylipins as developmental and host-fungal communication signals.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Johansson P, et al. (2008 Sep 2). Inhibition of the fungal fatty acid synthase type I multienzyme complex.

Johansson P, et al. (2009 Aug 12). Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG02002
EOG88PK71

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02003
EOG8T1G28

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted fatty acid synthase activity, transferase activity, role in fatty acid biosynthetic process, metabolic process, oxidation-reduction process and fatty acid synthase complex localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%