FOG02004
EOG84F4QX

sce:ACC1

Genes: 33

Protein description
Acetyl-CoA carboxylase


Features
[c]


SGD Description
Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog, HFA1, that arose from the whole genome duplication


PomBase Description
acetyl-CoA/biotin carboxylase


AspGD Description
Acetyl-CoA carboxylase; biotin carboxylase


References

Roggenkamp R, et al. (1980 Apr). Fatty acid-requiring mutant of Saccharomyces cerevisiae defective in acetyl-CoA carboxylase.

Mishina M, et al. (1980 Oct). Yeast mutants defective in acetyl-coenzyme A carboxylase and biotin: apocarboxylase ligase.

Hirano T, et al. (1986 Nov). Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Al-Feel W, et al. (1992 May 15). Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase.

Chirala SS, et al. (1992 Nov 1). Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae.

Hasslacher M, et al. (1993 May 25). Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism.

Vahlensieck HF, et al. (1994 Feb). Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A.

Chirala SS, et al. (1994 Feb 11). Analysis of FAS3/ACC regulatory region of Saccharomyces cerevisiae: identification of a functional UASINO and sequences responsible for fatty acid mediated repression.

Saitoh S, et al. (1996 Aug). Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase.

Schneiter R, et al. (1996 Dec). A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex.

Ivessa AS, et al. (1997 Dec). Yeast acetyl-CoA carboxylase is associated with the cytoplasmic surface of the endoplasmic reticulum.

Morrice J, et al. (1998 Dec). Isolation and characterisation of the acetyl-CoA carboxylase gene from Aspergillus nidulans.

Grishchuk EL, et al. (1998 Jul). A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.

Schneiter R, et al. (2000 May). A novel cold-sensitive allele of the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase, affects the morphology of the yeast vacuole through acylation of Vac8p.

Gao H, et al. (2003 Jul 11). Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p.

Zhang H, et al. (2003 Mar 28). Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase.

Zhang H, et al. (2004 Apr 20). Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop.

Shen Y, et al. (2004 Dec 22). A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product.

Wilkinson CR, et al. (2004 Dec 29). Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.

Miki F, et al. (2004 Jan). Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.

Ideue T, et al. (2004 Jun 15). The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Převorovský M, et al. (2015). Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles.

Mathiassen SG, et al. (2015 Aug 21). A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Převorovský M, et al. (2016 Nov 16). CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02005
EOG84F4QX

sce:HFA1

Genes: 1

Protein description
Mitochondrial acetyl-coenzyme A carboxylase


Features
[m];[c]


Parent
ohnolog:FOG02004


SGD Description
Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon


References

Kearsey SE, et al. (1993). Identification of a Saccharomyces cerevisiae gene closely related to FAS3 (acetyl-CoA carboxylase)

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Hoja U, et al. (2004 May 21). HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%