FOG01995
EOG81RNCN
ELO2
sce:ELO2

Genes: 33

Protein description
Fatty acid elongase


SGD Description
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication


PomBase Description
GNS1/SUR4 family protein (predicted)


AspGD Description
Ortholog(s) have fatty acid elongase activity, role in fatty acid elongation, sphingolipid biosynthetic process, vesicle-mediated transport and endoplasmic reticulum localization


References

Lorenz RT, et al. (1992 Nov). Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae.

Ladevèze V, et al. (1993 Oct). General resistance to sterol biosynthesis inhibitors in Saccharomyces cerevisiae.

el-Sherbeini M, et al. (1995 Jun). Cloning and characterization of GNS1: a Saccharomyces cerevisiae gene involved in synthesis of 1,3-beta-glucan in vitro.

Lees ND, et al. (1995 Mar). Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review.

Oh CS, et al. (1997 Jul 11). ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation.

David D, et al. (1998 Nov 30). Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast.

Rössler H, et al. (2003 May). Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG01996
EOG81RNCN
ELO3
sce:ELO3

Genes: 22

Protein description
Elongase; involved in fatty acid and sphingolipid biosynthesis


Parent
paralog:FOG01995


SGD Description
Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis


References

Naumovski L, et al. (1987 Oct). The RAD3 gene of Saccharomyces cerevisiae: isolation and characterization of a temperature-sensitive mutant in the essential function and of extragenic suppressors of this mutant.

Desfarges L, et al. (1993 Mar). Yeast mutants affected in viability upon starvation have a modified phospholipid composition.

García-Arranz M, et al. (1994 Jul 8). Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation.

Silve S, et al. (1996 Jun). The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae.

Oh CS, et al. (1997 Jul 11). ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation.

David D, et al. (1998 Nov 30). Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast.

Han G, et al. (2002 Sep 20). The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.

Rössler H, et al. (2003 May). Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG01997
EOG81RNCN
ELO1
sce:ELO1

Genes: 2

Protein description
Elongase I, medium-chain acyl elongase


Parent
ohnolog:FOG01995


SGD Description
Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication


References

Toke DA, et al. (1996 Aug 2). Isolation and characterization of a gene affecting fatty acid elongation in Saccharomyces cerevisiae.

Dittrich F, et al. (1998 Mar 15). Fatty acid elongation in yeast--biochemical characteristics of the enzyme system and isolation of elongation-defective mutants.

Schneiter R, et al. (2000 Jul). Elo1p-dependent carboxy-terminal elongation of C14:1Delta(9) to C16:1Delta(11) fatty acids in Saccharomyces cerevisiae.

Rössler H, et al. (2003 May). Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01998
EOG81RNCN
ELO2.2
sce:absent

Genes: 1

Protein description
Uncharacterized elongase paralog


Parent
paralog:FOG01995


PomBase Description
GNS1/SUR4 family protein (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01999
EOG81RNCN
ELO2.3
sce:absent

Genes: 1

Protein description
Uncharacterized elongase paralog


Parent
paralog:FOG01995

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%