FOG01972
EOG89320H

sce:ERG1

Genes: 33

SGD Description
Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine


PomBase Description
squalene monooxygenase Erg1 (predicted)


AspGD Description
Squalene monooxygenase


References

Jandrositz A, et al. (1991 Oct 30). The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization.

Satoh T, et al. (1993 Apr). Enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae.

Favre B, et al. (1997 Apr 11). Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans.

Marichal P, et al. (1997 Oct). Molecular biological characterization of an azole-resistant Candida glabrata isolate.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.

Mo C, et al. (2005 Sep). Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%