FOG01971
EOG8GXD40

sce:ERG9

Genes: 35

SGD Description
Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway


PomBase Description
farnesyldiphosphate:farnesyldiphosphatefarnesyltransferase (squalene synthase) Erg9


AspGD Description
Squalene synthase|Protein similar to squalene synthase


References

Jennings SM, et al. (1991 Jul 15). Molecular cloning and characterization of the yeast gene for squalene synthetase.

Fegueur M, et al. (1991 Nov). Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase.

Zhang D, et al. (1993 Jul). Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme.

Robinson GW, et al. (1993 May). Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.

Merkulov S, et al. (2000 Feb). Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation.

Nakayama H, et al. (2000 Sep). Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in mice.

Tafforeau L, et al. (2006 Oct 4). Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%