FOG01957
EOG8N8PNB

sce:HEM3

Genes: 35

SGD Description
Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme


PomBase Description
hydroxymethylbilane synthase Hem3 (predicted)


AspGD Description
Porphobilinogen deaminase (hydroxymethylbilane synthase, Uro I synthase)


References

Keng T, et al. (1992 Aug). Structure and regulation of yeast HEM3, the gene for porphobilinogen deaminase.

Zhang Z, et al. (2005). Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Zhou S, et al. (2012 Jan). Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01958
EOG8N8PNB

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted hydroxymethylbilane synthase activity and role in tetrapyrrole biosynthetic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%