FOG01956
EOG869PBD

sce:HEM2

Genes: 32

SGD Description
Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus


PomBase Description
porphobilinogen synthase Hem2 (predicted)


AspGD Description
5-aminolevulinic acid dehydratase (porphobilinogen synthase)


References

Myers AM, et al. (1987 Dec 15). Characterization of the yeast HEM2 gene and transcriptional regulation of COX5 and COR1 by heme.

Erskine PT, et al. (1997 Dec). X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.

Feuermann M, et al. (1997 Jul). The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes.

Hunter TC, et al. (1998 Mar). A role for HEM2 in cadmium tolerance.

Erskine PT, et al. (1999 Jun). The Schiff base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid.

Erskine PT, et al. (2000 Apr). MAD analyses of yeast 5-aminolaevulinate dehydratase: their use in structure determination and in defining the metal-binding sites.

Erskine PT, et al. (2001 Aug 17). The X-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with two diacid inhibitors.

Erskine PT, et al. (2001 Sep 7). The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%