FOG01949
EOG8WWQ1P

sce:ERG10

Genes: 36

SGD Description
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis


PomBase Description
acetyl-CoA C-acetyltransferase Erg10 (predicted)


AspGD Description
Acetyl-CoA C-acetyltransferase


References

Kornblatt JA, et al. (1971 Jul 25). Two forms of acetoacetyl coenzyme A thiolase in yeast. I. Separation and properties.

Hiser L, et al. (1994 Dec 16). ERG10 from Saccharomyces cerevisiae encodes acetoacetyl-CoA thiolase.

Dimster-Denk D, et al. (1996 Aug). Transcriptional regulation of a sterol-biosynthetic enzyme by sterol levels in Saccharomyces cerevisiae.

Baek ST, et al. (2008 Feb). Genome-wide drug-induced haploinsufficient screening of fission yeast for identification of hydrazinocurcumin targets.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01950
EOG8WWQ1P

sce:absent

Genes: 6

AspGD Description
3-ketoacyl-CoA thiolase|Putative acetyl-CoA acetyltransferase; 3-ketoacyl-CoA thiolase; induced by fenpropimorph


References

Hynes MJ, et al. (2006 May). Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.

Hynes MJ, et al. (2008 Mar). Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG01951
EOG8WWQ1P

sce:POT1

Genes: 37

SGD Description
3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids


AspGD Description
Putative ketothiolase; 3-ketoacyl-CoA thiolase


References

Einerhand AW, et al. (1991 Aug 15). Regulation of transcription of the gene coding for peroxisomal 3-oxoacyl-CoA thiolase of Saccharomyces cerevisiae.

Igual JC, et al. (1991 May-Jun). A new glucose-repressible gene identified from the analysis of chromatin structure in deletion mutants of yeast SUC2 locus.

Berninger G, et al. (1993 Sep 1). Structure and metabolic control of the Yarrowia lipolytica peroxisomal 3-oxoacyl-CoA-thiolase gene.

Glover JR, et al. (1994 Mar 11). Mutagenesis of the amino targeting signal of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase reveals conserved amino acids required for import into peroxisomes in vivo.

Mathieu M, et al. (1994 Sep 15). The 2.8 A crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha beta alpha beta alpha structure constructed from two core domains of identical topology.

Mathieu M, et al. (1997 Oct 31). The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 14 genes with posterior transmembrane prediction > 50%

FOG01952
EOG8612NT
EOG8W6MC9
EOG8WWQ1P

sce:SLX1

Genes: 44

SGD Description
Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p


PomBase Description
structure-specific endonuclease catalytic subunit Slx1


AspGD Description
3-ketoacyl-CoA thiolase|Ortholog(s) have 5'-flap endonuclease activity, role in DNA-dependent DNA replication, double-strand break repair via homologous recombination, recombination within rDNA repeats and Slx1-Slx4 complex, nucleolar chromatin localization


References

Mullen JR, et al. (2001 Jan). Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.

Fricke WM, et al. (2003 Jul 15). Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG01953
EOG8612NT

sce:absent

Genes: 2

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN7004, A. fumigatus Af293 : Afu4g04450, A. oryzae RIB40 : AO090206000048, Aspergillus wentii : Aspwe1_0043225 and Aspergillus sydowii : Aspsy1_0034669

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01954
EOG8R229H
EOG8WWQ1P

sce:HEM1

Genes: 41

SGD Description
5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p


PomBase Description
5-aminolevulinate synthase Hem1


AspGD Description
Acetyl-CoA C-acetyltransferase, acetoacetyl-CoA thiolase|Aminolevulinic acid synthase (5-aminolevulinate synthase); predicted mitochonrial signal sequence; mutant is conditionally lethal when grown on nitrate medium containing 5'-aminolevulinic acid but not with hemin


References

Volland C, et al. (1984 Aug 1). Isolation and properties of 5-aminolevulinate synthase from the yeast Saccharomyces cerevisiae.

Keng T, et al. (1986 Feb). The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix.

Urban-Grimal D, et al. (1986 May 2). The nucleotide sequence of the HEM1 gene and evidence for a precursor form of the mitochondrial 5-aminolevulinate synthase in Saccharomyces cerevisiae.

Keng T, et al. (1987 Dec). Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression.

Bradshaw RE, et al. (1993 May-Jun). Isolation and nucleotide sequence of the 5-aminolevulinate synthase gene from Aspergillus nidulans.

González-Domínguez M, et al. (1997 Aug). Isolation and characterization of the KlHEM1 gene in Kluyveromyces lactis.

Yamagami S, et al. (2001 Apr 6). Isolation and characterization of acetoacetyl-CoA thiolase gene essential for n-decane assimilation in yeast Yarrowia lipolytica.

Maggio-Hall LA, et al. (2004 Dec). Mitochondrial beta-oxidation in Aspergillus nidulans.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Hynes MJ, et al. (2008 Mar). Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans.

Roberts-Galbraith RH, et al. (2009 Jan 12). The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mourer T, et al. (2015 Apr 17). Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.

Kardon JR, et al. (2015 May 7). Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG01955
EOG8612NT

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%