FOG01948
EOG808KRK

sce:COQ8

Genes: 34

SGD Description
Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication


PomBase Description
ABC1 kinase family ubiquinone biosynthesis protein Abc1/Coq8


AspGD Description
Ortholog(s) have protein kinase activity and role in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate, ubiquinone-6 biosynthetic process


References

Bousquet I, et al. (1991 Aug). ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex.

Poon WW, et al. (1997). Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants.

Brasseur G, et al. (1997 May 15). The nuclear ABC1 gene is essential for the correct conformation and functioning of the cytochrome bc1 complex and the neighbouring complexes II and IV in the mitochondrial respiratory chain.

Hsu AY, et al. (2000 Apr 12). Genetic evidence for a multi-subunit complex in the O-methyltransferase steps of coenzyme Q biosynthesis.

Do TQ, et al. (2001 May 25). A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants.

Hsieh EJ, et al. (2004 Apr 30). A tRNA(TRP) gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Tauche A, et al. (2008 Dec). Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p.

Padilla S, et al. (2009 Jan). Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis.

Xie LX, et al. (2011 May). Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants.

Stefely JA, et al. (2015 Jan 8). Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.

Stefely JA, et al. (2016 Aug 18). Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%