FOG01876
EOG80GB8W

sce:DFG10

Genes: 31

Protein description
SRD5A3


SGD Description
Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)


PomBase Description
3-oxo-5-alpha-steroid 4-dehydrogenase (predicted)


AspGD Description
Ortholog(s) have role in dolichol biosynthetic process, dolichol-linked oligosaccharide biosynthetic process, polyprenol catabolic process, pseudohyphal growth


References

Mösch HU, et al. (1997 Mar). Dissection of filamentous growth by transposon mutagenesis in Saccharomyces cerevisiae.

Cantagrel V, et al. (2010 Jul 23). SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%