FOG01786
EOG8X3FH4

sce:UGP1

Genes: 34

SGD Description
UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication


PomBase Description
UTP-glucose-1-phosphate uridylyltransferase Fyu1|UTP-glucose-1-phosphate uridylyltransferase-like Ugp1


AspGD Description
Putative UTP-glucose-1-phosphate uridylyltransferase; Leloir pathway enzyme; induced by caspofungin


References

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Nakafuku M, et al. (1987 Apr). Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

Dietzel C, et al. (1987 Sep 25). The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway.

Jahng KY, et al. (1988 Jun). Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.

Blinder D, et al. (1989 Feb 10). Constitutive mutants in the yeast pheromone response: ordered function of the gene products.

Fujimura HA, et al. (1989 Jan). The yeast G-protein homolog is involved in the mating pheromone signal transduction system.

Miyajima I, et al. (1989 Jun). GPA1Val-50 mutation in the mating-factor signaling pathway in Saccharomyces cerevisiae.

Cole GM, et al. (1990 Feb). Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway.

Blumer KJ, et al. (1990 Jun). Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling.

Nomoto S, et al. (1990 Mar). Regulation of the yeast pheromone response pathway by G protein subunits.

Stone DE, et al. (1990 Sep). G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.

Hirsch JP, et al. (1991 Mar). The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors.

Kurjan J, et al. (1991 Mar). Mutations in the guanine nucleotide-binding domains of a yeast G alpha protein confer a constitutive or uninducible state to the pheromone response pathway.

Stone DE, et al. (1991 Nov). N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase.

Zhang M, et al. (1993 Aug). Suppression of a dominant G-protein beta-subunit mutation in yeast by G alpha protein expression.

Clark KL, et al. (1993 Jan). Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating.

Dohlman HG, et al. (1993 Oct 15). Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.

Daran JM, et al. (1995 Oct 15). Genetic and biochemical characterization of the UGP1 gene encoding the UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae.

Song J, et al. (1996 Aug 23). Regulation of membrane and subunit interactions by N-myristoylation of a G protein alpha subunit in yeast.

Stratton HF, et al. (1996 Nov). The mating-specific G(alpha) protein of Saccharomyces cerevisiae downregulates the mating signal by a mechanism that is dependent on pheromone and independent of G(beta)(gamma) sequestration.

Song J, et al. (1996 Nov 26). Partial constitutive activation of pheromone responses by a palmitoylation-site mutant of a G protein alpha subunit in yeast.

Dohlman HG, et al. (1996 Sep). Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).

DeSimone SM, et al. (1998 Apr). Switch-domain mutations in the Saccharomyces cerevisiae G protein alpha-subunit Gpa1p identify a receptor subtype-biased mating defect.

Apanovitch DM, et al. (1998 Apr 7). Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast.

DiBello PR, et al. (1998 Mar 6). Selective uncoupling of RGS action by a single point mutation in the G protein alpha-subunit.

Apanovitch DM, et al. (1998 Oct 30). Second site suppressor mutations of a GTPase-deficient G-protein alpha-subunit. Selective inhibition of Gbeta gamma-mediated signaling.

Zhou J, et al. (1999). The yeast pheromone-responsive G alpha protein stimulates recovery from chronic pheromone treatment by two mechanisms that are activated at distinct levels of stimulus.

Dosil M, et al. (2000 Jul). The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.

Manahan CL, et al. (2000 Mar). Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae.

Kallal L, et al. (2000 Mar 30). The GTP hydrolysis defect of the Saccharomyces cerevisiae mutant G-protein Gpa1(G50V).

Cismowski MJ, et al. (2001 Jun 8). Biochemical analysis of yeast G(alpha) mutants that enhance adaptation to pheromone.

Marotti LA Jr, et al. (2002 Apr 23). Direct identification of a G protein ubiquitination site by mass spectrometry.

Duncan JA, et al. (2002 Aug 30). Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo.

Metodiev MV, et al. (2002 May 24). Regulation of MAPK function by direct interaction with the mating-specific Galpha in yeast.

Guo M, et al. (2003 Aug). The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.

Blackwell E, et al. (2003 Feb). Effect of the pheromone-responsive G(alpha) and phosphatase proteins of Saccharomyces cerevisiae on the subcellular localization of the Fus3 mitogen-activated protein kinase.

Urban C, et al. (2003 Jun 5). Identification of cell surface determinants in Candida albicans reveals Tsa1p, a protein differentially localized in the cell.

Yi TM, et al. (2003 Sep 16). A quantitative characterization of the yeast heterotrimeric G protein cycle.

Wu YL, et al. (2004 Aug 20). Dominant-negative inhibition of pheromone receptor signaling by a single point mutation in the G protein alpha subunit.

Roginskaya M, et al. (2004 Mar). Effects of mutations in the N terminal region of the yeast G protein alpha-subunit Gpa1p on signaling by pheromone receptors.

Wang Y, et al. (2005 Jan 7). Differential regulation of G protein alpha subunit trafficking by mono- and polyubiquitination.

Roeben A, et al. (2006 Dec 8). Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae.

Chasse SA, et al. (2006 Feb). Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.

Slessareva JE, et al. (2006 Jul 14). Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Kusch H, et al. (2007 Mar). Proteomic analysis of the oxidative stress response in Candida albicans.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Kusch H, et al. (2008 Apr). A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Buchheit D, et al. (2011 Dec). Production of ibuprofen acyl glucosides by human UGT2B7.

Etxebeste O, et al. (2012). GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans.

Fanning S, et al. (2012 Jul). Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Srikantha T, et al. (2013 Jun). Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Low JK, et al. (2013 Sep 6). Analysis of the proteome of Saccharomyces cerevisiae for methylarginine.

Alam MK, et al. (2014). Aspergillus nidulans cell wall composition and function change in response to hosting several Aspergillus fumigatus UDP-galactopyranose mutase activity mutants.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Park J, et al. (2015 Nov 2). Identification and functional analysis of two Golgi-localized UDP-galactofuranose transporters with overlapping functions in Aspergillus niger.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%