FOG01787
EOG8DBRVD
sce:FKS1;GSC2
Genes: 41
EOG8DBRVD
sce:FKS1;GSC2
Genes: 41
SGD Description
Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication|Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication
PomBase Description
1,3-beta-glucan synthase catalytic subunit Bgs1|1,3-beta-glucan synthase subunit Bgs2|1,3-beta-glucan synthase subunit Bgs3|1,3-beta-glucan synthase subunit Bgs4
AspGD Description
Beta-1,3-glucan synthase
References
Parent SA, et al. (1993 Dec). Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae.
Douglas CM, et al. (1994 Dec 20). The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.
Eng WK, et al. (1994 Dec 30). The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.
Garrett-Engele P, et al. (1995 Aug). Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.
Inoue SB, et al. (1995 Aug 1). Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae.
Ram AF, et al. (1995 Jan 23). Identification of two cell cycle regulated genes affecting the beta 1,3-glucan content of cell walls in Saccharomyces cerevisiae.
Castro C, et al. (1995 Oct). Papulacandin B resistance in budding and fission yeasts: isolation and characterization of a gene involved in (1,3)beta-D-glucan synthesis in Saccharomyces cerevisiae.
Mazur P, et al. (1995 Oct). Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase.
Qadota H, et al. (1996 Apr 12). Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.
Kelly R, et al. (1996 Aug). Isolation of a gene involved in 1,3-beta-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein.
Mazur P, et al. (1996 Jun 14). In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1.
Dessen P, et al. (2000 Feb 22). The PAUSE software for analysis of translational control over protein targeting: application to E. nidulans membrane proteins.
Liu J, et al. (2000 Jul 28). Bgs2p, a 1,3-beta-glucan synthase subunit, is essential for maturation of ascospore wall in Schizosaccharomyces pombe.
Pereira M, et al. (2000 Mar 30). Molecular cloning and characterization of a glucan synthase gene from the human pathogenic fungus Paracoccidioides brasiliensis.
Martín V, et al. (2000 Oct). bgs2+, a sporulation-specific glucan synthase homologue is required for proper ascospore wall maturation in fission yeast.
Utsugi T, et al. (2002 Jan). Movement of yeast 1,3-beta-glucan synthase is essential for uniform cell wall synthesis.
Dijkgraaf GJ, et al. (2002 Jun 15). Mutations in Fks1p affect the cell wall content of beta-1,3- and beta-1,6-glucan in Saccharomyces cerevisiae.
Sekiya-Kawasaki M, et al. (2002 Oct). Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae.
Martín V, et al. (2003 Feb). Bgs3p, a putative 1,3-beta-glucan synthase subunit, is required for cell wall assembly in Schizosaccharomyces pombe.
Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.
Hitchcock AL, et al. (2003 Oct 28). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Ohyama T, et al. (2004 Jan). FKS1 mutations responsible for selective resistance of Saccharomyces cerevisiae to the novel 1,3-beta-glucan synthase inhibitor arborcandin C.
Lesage G, et al. (2004 May). Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin.
Huang LS, et al. (2005 Aug 30). The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.
Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.
Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Fujioka T, et al. (2007 Aug). MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans.
Ishihara S, et al. (2007 Feb). Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae.
Li S, et al. (2007 May). basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Tóth V, et al. (2012 Jul). The echinocandin B producer fungus Aspergillus nidulans var. roseus ATCC 58397 does not possess innate resistance against its lipopeptide antimycotic.
Yoshimi A, et al. (2013). Functional analysis of the α-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: agsB is the major α-1,3-glucan synthase in this fungus.
de León N, et al. (2013). Regulation of cell wall synthesis by the clathrin light chain is essential for viability in Schizosaccharomyces pombe.
Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Park BC, et al. (2014 Nov). Transcriptional regulation of fksA, a β-1,3-glucan synthase gene, by the APSES protein StuA during Aspergillus nidulans development.
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Park HS, et al. (2015 May 11). Velvet-mediated repression of β-glucan synthesis in Aspergillus nidulans spores.
Hoya M, et al. (2017 Feb). Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
39 genes with posterior transmembrane prediction > 50% |
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FOG01788
sce:absent
Genes: 0
sce:absent
Genes: 0
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG01789
EOG8DBRVD
sce:FKS3
Genes: 22
EOG8DBRVD
sce:FKS3
Genes: 22
SGD Description
Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
References
Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.
Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Ishihara S, et al. (2007 Feb). Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae.
Kung LA, et al. (2009). Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
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| Phobius transmembrane predictions
22 genes with posterior transmembrane prediction > 50% |
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FOG01790
EOG8DBRVD
sce:absent
Genes: 20
EOG8DBRVD
sce:absent
Genes: 20
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
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| Raw data
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| Phobius transmembrane predictions
20 genes with posterior transmembrane prediction > 50% |
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